Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.
Syndax PharmaceuticalsSNDX -3.42%27 Debt-to-EBITDA is -4.02 as of Jun. 2026. GuruFocus rates SNDX with a GF Score™ of 27/100. The stock has 5 warning signs investors should review. Among 309 Biotechnology companies, Syndax Pharmaceuticals ranks worse than 323624.27% on this metric.
Debt-to-EBITDA measures a company's ability to pay off its debt.
A high Debt-to-EBITDA ratio generally means that a company may spend more time to paying off its debt. According to Joel Tillinghast's BIG MONEY THINKS SMALL: Biases, Blind Spots, and Smarter Investing, a ratio of Debt-to-EBITDA exceeding four is usually considered scary unless tangible assets cover the debt.
The historical rank and industry rank for Syndax Pharmaceuticals's Debt-to-EBITDA or its related term are showing as below:
SNDX'
s Debt-to-EBITDA Range Over the Past 10 Years
Min: -3.31 Med: -0.02 Max: 0.78
Current: -3.31
During the past 13 years, the highest Debt-to-EBITDA Ratio of Syndax Pharmaceuticals was 0.78. The lowest was -3.31. And the median was -0.02.
SNDX's Debt-to-EBITDA is ranked worse than 100% of 309
companies
in the Biotechnology industry
Industry Median: 1.39
vs SNDX: -3.31
A high Debt-to-EBITDA ratio generally means that a company may spend more time to paying off its debt.
According to Joel Tillinghast's BIG MONEY THINKS SMALL: Biases, Blind Spots, and Smarter Investing, a ratio of Debt-to-EBITDA exceeding four is usually considered scary unless tangible assets cover the debt.
Syndax Pharmaceuticals Debt-to-EBITDA Related Terms
Syndax Pharmaceuticals Debt-to-EBITDA Historical Data
* Premium members only.
The historical data trend for Syndax Pharmaceuticals's Debt-to-EBITDA can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
SNDX vs FTRE, KARD, STOK: Debt-to-EBITDA Comparison
For the Biotechnology subindustry, Syndax Pharmaceuticals's Debt-to-EBITDA, along with its competitors' market caps and Debt-to-EBITDA data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Syndax Pharmaceuticals Debt-to-EBITDA vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Syndax Pharmaceuticals's Debt-to-EBITDA distribution charts can be found below:
* The bar in red indicates where Syndax Pharmaceuticals's Debt-to-EBITDA falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
In the calculation of annual Debt-to-EBITDA, the EBITDA of the last fiscal year is used. In calculating the annualized quarterly data,
the EBITDA data used here is four times the quarterly (Jun. 2026) EBITDA data.
Syndax Pharmaceuticals (SNDX) has a Debt-to-EBITDA of -4.02 as of Jun. 2026. Debt-to-EBITDA ratio represents the ratio of total debt to total earnings before interest, taxes, depreciation and amortization. View historical data on Syndax Pharmaceuticals. According to the industry distribution chart, Syndax Pharmaceuticals ranks #999999 out of 309 companies in the Biotechnology industry.
Is Syndax Pharmaceuticals' Debt-to-EBITDA too high?
Syndax Pharmaceuticals' current Debt-to-EBITDA is -4.02. Based on the distribution chart, Syndax Pharmaceuticals ranks #999999 out of 309 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Syndax Pharmaceuticals has a GF Score™ of 27/100, reflecting its overall financial health beyond just this single metric.
How does Syndax Pharmaceuticals' Debt-to-EBITDA compare to FTRE and KARD?
According to the Biotechnology industry distribution chart, Syndax Pharmaceuticals ranks #999999 out of 309 companies for Debt-to-EBITDA. This places Syndax Pharmaceuticals in the lower half of its industry. The industry median Debt-to-EBITDA is 1.39. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Debt-to-EBITDA for a Biotechnology company?
The median Debt-to-EBITDA among Biotechnology companies is 1.39, based on 309 companies in the industry. Companies in the top quartile (top 25%) have a Debt-to-EBITDA significantly above this median, while those in the bottom quartile fall well below. However, Debt-to-EBITDA should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Debt-to-EBITDA mean?
A high Debt-to-EBITDA can signal that a stock is expensive relative to its fundamentals. Debt-to-EBITDA ratio represents the ratio of total debt to total earnings before interest, taxes, depreciation and amortization. View historical data on Syndax Pharmaceuticals. For the Biotechnology industry, the median Debt-to-EBITDA is 1.39 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Syndax Pharmaceuticals's current Debt-to-EBITDA is -4.02. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Syndax Pharmaceuticals stock overvalued right now?
Syndax Pharmaceuticals (SNDX) has a current Debt-to-EBITDA of -4.02. The current Debt-to-EBITDA is -4.02. Syndax Pharmaceuticals' overall GF Score™ is 27/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Debt-to-EBITDA calculated?
Debt-to-EBITDA is calculated from a company's financial statements. For Syndax Pharmaceuticals (SNDX), the current Debt-to-EBITDA is -4.02 as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Syndax Pharmaceuticals Inc is a clinical-stage biopharmaceutical company focused on developing a pipeline of combination therapies in multiple cancer indications. Its product candidates include revumenib and axatilimab. It is developing revumenib, a selective menin-MLL inhibitor for KMT2A-rearranged (MLL-r) and NPM1-mutant acute leukemias, including ALL and AML. It is also developing axatilimab, a CSF-1R-blocking antibody for cGVHD and idiopathic pulmonary fibrosis. Entinostat is its oral, small molecule product candidate that has direct effects on both cancer cells and immune regulatory cells. The business activity of the group is functioned through the region of the United States.
27GF Score
Get the complete analysis for SNDX
Debt-to-EBITDA is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
Quick Browse
Personalize
Premium Gurus 
Create New Portfolio
SNDX has been successfully added to your 
