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Syn2bioWAR:S2B -0.44%9 Debt-to-EBITDA is -0.02 as of Sep. 2025. GuruFocus rates WAR:S2B with a GF Score™ of 9/100. The stock has 1 warning sign investors should review. Among 316 Biotechnology companies, Syn2bio ranks worse than 316455.38% on this metric.
Debt-to-EBITDA measures a company's ability to pay off its debt.
A high Debt-to-EBITDA ratio generally means that a company may spend more time to paying off its debt. According to Joel Tillinghast's BIG MONEY THINKS SMALL: Biases, Blind Spots, and Smarter Investing, a ratio of Debt-to-EBITDA exceeding four is usually considered scary unless tangible assets cover the debt.
The historical rank and industry rank for Syn2bio's Debt-to-EBITDA or its related term are showing as below:
WAR:S2B'
s Debt-to-EBITDA Range Over the Past 10 Years
Min: -0.05 Med: -0.03 Max: -0.02
Current: -0.02
During the past 3 years, the highest Debt-to-EBITDA Ratio of Syn2bio was -0.02. The lowest was -0.05. And the median was -0.03.
WAR:S2B's Debt-to-EBITDA is ranked worse than 100% of 316
companies
in the Biotechnology industry
Industry Median: 1.255
vs WAR:S2B: -0.02
A high Debt-to-EBITDA ratio generally means that a company may spend more time to paying off its debt.
According to Joel Tillinghast's BIG MONEY THINKS SMALL: Biases, Blind Spots, and Smarter Investing, a ratio of Debt-to-EBITDA exceeding four is usually considered scary unless tangible assets cover the debt.
Syn2bio Debt-to-EBITDA Related Terms
Syn2bio Debt-to-EBITDA Historical Data
* Premium members only.
The historical data trend for Syn2bio's Debt-to-EBITDA can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Syn2bio Debt-to-EBITDA Chart
Syn2bio Annual Data
Trend
Sep23
Sep24
Sep25
Debt-to-EBITDA
-0.05
-0.03
-0.02
Syn2bio Semi-Annual Data
Sep23
Sep24
Sep25
Debt-to-EBITDA
-0.05
-0.03
-0.02
WAR:S2B vs VRTX, REGN, RVMD: Debt-to-EBITDA Comparison
For the Biotechnology subindustry, Syn2bio's Debt-to-EBITDA, along with its competitors' market caps and Debt-to-EBITDA data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Syn2bio Debt-to-EBITDA vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Syn2bio's Debt-to-EBITDA distribution charts can be found below:
* The bar in red indicates where Syn2bio's Debt-to-EBITDA falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
In the calculation of annual Debt-to-EBITDA, the EBITDA of the last fiscal year is used. In calculating the annualized quarterly data,
the EBITDA data used here is one times the quarterly (Sep. 2025) EBITDA data.
Syn2bio (WAR:S2B) has a Debt-to-EBITDA of -0.02 as of Sep. 2025. Debt-to-EBITDA ratio represents the ratio of total debt to total earnings before interest, taxes, depreciation and amortization. View historical data on Syn2bio. According to the industry distribution chart, Syn2bio ranks #999999 out of 316 companies in the Biotechnology industry.
Is Syn2bio's Debt-to-EBITDA too high?
Syn2bio's current Debt-to-EBITDA is -0.02. Based on the distribution chart, Syn2bio ranks #999999 out of 316 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Syn2bio has a GF Score™ of 9/100, reflecting its overall financial health beyond just this single metric.
How does Syn2bio's Debt-to-EBITDA compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Syn2bio ranks #999999 out of 316 companies for Debt-to-EBITDA. This places Syn2bio in the lower half of its industry. The industry median Debt-to-EBITDA is 1.26. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Debt-to-EBITDA for a Biotechnology company?
The median Debt-to-EBITDA among Biotechnology companies is 1.26, based on 316 companies in the industry. Companies in the top quartile (top 25%) have a Debt-to-EBITDA significantly above this median, while those in the bottom quartile fall well below. However, Debt-to-EBITDA should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Debt-to-EBITDA mean?
A high Debt-to-EBITDA can signal that a stock is expensive relative to its fundamentals. Debt-to-EBITDA ratio represents the ratio of total debt to total earnings before interest, taxes, depreciation and amortization. View historical data on Syn2bio. For the Biotechnology industry, the median Debt-to-EBITDA is 1.26 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Syn2bio's current Debt-to-EBITDA is -0.02. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Syn2bio stock overvalued right now?
Syn2bio (WAR:S2B) has a current Debt-to-EBITDA of -0.02. The current Debt-to-EBITDA is -0.02. Syn2bio's overall GF Score™ is 9/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Debt-to-EBITDA calculated?
Debt-to-EBITDA is calculated from a company's financial statements. For Syn2bio (WAR:S2B), the current Debt-to-EBITDA is -0.02 as of Sep. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Syn2bio SA is a Polish biotech company that develops radiopharmaceuticals. It specializes in developing a cardiac biomarker for diagnosing heart conditions like coronary artery disease through myocardial perfusion imaging. The company's flagship product is the SYN2 cardiotracer. It is applied in the detection of perfusion disorders, evaluation of patients after myocardial infarction or with ischemic heart disease, and assessment of atherosclerotic changes in coronary arteries.
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Debt-to-EBITDA is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
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