AGEN (Agenus) E10: $-19.09 (As of Jun. 2026)

Author: Vera Yuan Vera Yuan
Vera Yuan
Vera Yuan
Director of Data and Quant Analytics at GuruFocus
Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Reviewed by: Charlie Tian Charlie Tian
Charlie Tian
Charlie Tian
Founder & CEO of GuruFocus
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.

AGEN Agenus Inc AGEN
43 GF Score
Price $7.16
GF Value $3.78
Valuation Significantly Overvalued
! 12 Warning Signs
View Full Analysis

What is Agenus E10?

Agenus AGEN -2.32% 43 E10 is $-19.09 as of Jun. 2026. GuruFocus rates AGEN with a GF Score™ of 43/100 and a GF Value™ of $3.78 (Significantly Overvalued). The stock has 12 warning signs investors should review.

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller P/E calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years.

Agenus's adjusted earnings per share data for the three months ended in Jun. 2026 was $-0.010. Add all the adjusted EPS for the past 10 years together and divide 10 will get our e10, which is $-19.09 for the trailing ten years ended in Jun. 2026.

During the past 3 years, the average E10 Growth Rate was 5.00% per year. During the past 5 years, the average E10 Growth Rate was 1.40% per year. During the past 10 years, the average E10 Growth Rate was 7.00% per year. Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the E10 growth rate using E10 data.

During the past 13 years, the highest 3-Year average E10 Growth Rate of Agenus was 24.80% per year. The lowest was -1.30% per year. And the median was 15.60% per year.

As of today (2026-08-18), Agenus's current stock price is $7.155. Agenus's E10 for the quarter that ended in Jun. 2026 was $-19.09. Agenus's Shiller PE Ratio of today is .


Agenus  (NAS:AGEN) E10 Explanation

If a company grows much fast than inflation, E10 may underestimate the company's earnings power. Shiller PE Ratio can seem to be too high even the actual P/E is low.

For the Shiller P/E, the earnings of the past 10 years are inflation-adjusted and averaged. The result is used for P/E calculation. Since it looks at the average over the last 10 years, the Shiller P/E is also called PE10.

The Shiller P/E was first used by professor Robert Shiller to measure the valuation of the overall market. The same calculation is applied here to individual companies.


Be Aware

Shiller PE Ratio works better for cyclical companies. It gives you a better idea on the company's real earnings power.


Agenus E10 Related Terms


Agenus E10 Historical Data

* Premium members only.

The historical data trend for Agenus's E10 can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Agenus E10 Chart

Agenus Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
E10
Get a 7-Day Free Trial Premium Member Only Premium Member Only -22.14 -23.90 -23.08 -22.99 -20.51

Agenus Quarterly Data
Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26 Jun26
E10 Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -21.50 -21.02 -20.51 -19.77 -19.09

AGEN vs FULC, IRD, TTRX: E10 Comparison

For the Biotechnology subindustry, Agenus's Shiller PE Ratio, along with its competitors' market caps and Shiller PE Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Agenus Shiller PE Ratio vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Agenus's Shiller PE Ratio distribution charts can be found below:

* The bar in red indicates where Agenus's Shiller PE Ratio falls into.


AGEN
43GF Score
Agenus Inc AGEN
E10 is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Agenus E10 Calculation

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller P/E calculation. When we calculate the today's Shiller P/E ratio of a stock, we use today's price divided by E10.

What is E10? How do we calculate E10?

E10 is the average of the inflation adjusted earnings of a company over the past 10 years. Let's use an example to explain.

If we want to calculate the E10 of Wal-Mart (WMT) for Dec. 31, 2010, we need to have the inflation data and the earnings from 2001 through 2010.

We adjusted the earnings of 2001 earnings data with the total inflation from 2001 through 2010 to the equivalent earnings in 2010. If the total inflation from 2001 to 2010 is 40%, and Wal-Mart earned $1 a share in 2001, then the 2001's equivalent earnings in 2010 is $1.4 a share. If Wal-Mart earns $1 again in 2002, and the total inflation from 2002 through 2010 is 35%, then the equivalent 2002 earnings in 2010 is $1.35. So on and so forth, you get the equivalent earnings of past 10 years. Then you add them together and divided the sum by 10 to get E10.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

For example, Agenus's adjusted earnings per share data for the three months ended in Jun. 2026 was:

Adj_EPS= Earnings per Share (Diluted) /CPI of Jun. 2026 (Change)*Current CPI (Jun. 2026)
=-0.01/333.9520*333.9520
=-0.010

Current CPI (Jun. 2026) = 333.9520.

Agenus Quarterly Data

per share eps CPI Adj_EPS
201609 -9.400 241.428 -13.002
201612 -6.000 241.432 -8.299
201703 -3.600 243.801 -4.931
201706 -6.400 244.955 -8.725
201709 -7.400 246.819 -10.012
201712 -7.000 246.524 -9.483
201803 -10.600 249.554 -14.185
201806 -4.800 251.989 -6.361
201809 -5.800 252.439 -7.673
201812 -8.000 251.233 -10.634
201903 2.400 254.202 3.153
201906 -7.600 256.143 -9.909
201909 -6.600 256.759 -8.584
201912 -4.400 256.974 -5.718
202003 -6.200 258.115 -8.022
202006 -5.600 257.797 -7.254
202009 -5.600 260.280 -7.185
202012 -3.600 260.474 -4.616
202103 -5.400 264.877 -6.808
202106 -7.400 271.696 -9.096
202109 14.400 274.310 17.531
202112 -6.000 278.802 -7.187
202203 -3.800 287.504 -4.414
202206 -3.400 296.311 -3.832
202209 -3.800 296.808 -4.276
202212 -4.840 296.797 -5.446
202303 -4.310 301.836 -4.769
202306 -3.930 305.109 -4.302
202309 -3.290 307.789 -3.570
202312 -2.320 306.746 -2.526
202403 -3.040 312.332 -3.250
202406 -2.520 314.175 -2.679
202409 -3.080 315.301 -3.262
202412 -1.940 315.605 -2.053
202503 -1.030 319.799 -1.076
202506 -1.000 322.561 -1.035
202509 1.940 324.800 1.995
202512 -0.370 324.054 -0.381
202603 1.020 330.213 1.032
202606 -0.010 333.952 -0.010

Add all the adjusted EPS together and divide 10 will get our e10.

Frequently Asked Questions Learn more about E10 →
What does a E10 of $-19.09 mean?
Agenus (AGEN) has a E10 of $-19.09 as of Jun. 2026. E10 represents the company's inflation-adjusted earnings per share over a 10-year period. View historical data on Agenus and its competitors.
Is Agenus' E10 too high?
Agenus' current E10 is $-19.09. Overall, Agenus has a GF Score™ of 43/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Agenus' E10 compare to FULC and IRD?
Agenus' E10 of $-19.09 can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good E10 for a Biotechnology company?
A good E10 depends on the Biotechnology industry context. However, E10 should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high E10 mean?
A high E10 can signal that a stock is expensive relative to its fundamentals. E10 represents the company's inflation-adjusted earnings per share over a 10-year period. View historical data on Agenus and its competitors. Agenus's current E10 is $-19.09. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Agenus stock overvalued right now?
Based on GuruFocus' analysis, Agenus (AGEN) is currently considered Significantly Overvalued. The stock's GF Value™ is $3.78, compared to a current price of $7.16 — trading 89.3% above its estimated fair value. The current E10 is $-19.09. Agenus' overall GF Score™ is 43/100 with 12 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is E10 calculated?
E10 is calculated from a company's financial statements. For Agenus (AGEN), the current E10 is $-19.09 as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Agenus (AGEN) Overvalued in 2026?

Based on GuruFocus' analysis, Agenus stock appears to be overvalued. The current stock price of $7.16 is trading 89.3% above its estimated GF Value™ of $3.78. GuruFocus considers Agenus to be Significantly Overvalued.

Key valuation signals for AGEN:

  • E10: $-19.09
  • GF Value™: $3.78 vs. price of $7.16 (89.3% above fair value)
  • GF Score™: 43/100 with 12 warning signs

No single metric tells the full story. See the AGEN stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Agenus Business Description

Other Exchanges AJ8:Germany
Address 3 Forbes Road, Lexington, MA, USA, 02421
Agenus Inc is a clinical-stage biotechnology company focused on discovering and developing immunotherapies for cancer and infectious diseases. Its primary business is immuno-oncology (I-O), where it advances antibody-based programs designed to activate innate and adaptive immunity, overcome tumor immune evasion, and expand the number of patients who may benefit from immunotherapy. The Company's clinical program includes botensilimab (BOT or AGEN1181), both as a monotherapy and in combination with balstilimab (BAL), alongside a portfolio of other clinical-stage immuno-oncology assets that may be used independently or in combination therapies. The Company operates in the United States, which contributes the majority of its revenue, as well as in other international markets.
43GF Score

Get the complete analysis for AGEN

E10 is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$7.16
Price
$3.78
GF Value