Macrogenics (FRA:M55) EV-to-EBIT: -2.28 (As of Aug. 12, 2026)

Author: Vera Yuan Vera Yuan
Vera Yuan
Vera Yuan
Director of Data and Quant Analytics at GuruFocus
Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Reviewed by: Charlie Tian Charlie Tian
Charlie Tian
Charlie Tian
Founder & CEO of GuruFocus
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.

FRA:M55 Macrogenics Inc FRA:M55
48 GF Score
Price €3.52
GF Value €3.13
! 5 Warning Signs
View Full Analysis

What is Macrogenics EV-to-EBIT?

Macrogenics FRA:M55 +2.33% 48 EV-to-EBIT is -2.28 as of Aug. 12, 2026. GuruFocus rates FRA:M55 with a GF Score™ of 48/100 and a GF Value™ of €3.13. The stock has 5 warning signs investors should review. Among 367 Biotechnology companies, Macrogenics ranks worse than 272479.29% on this metric.

EV-to-EBIT is calculated as Enterprise Value divided by its EBIT. As of today, Macrogenics's Enterprise Value is €114.1 Mil. Macrogenics's EBIT for the trailing twelve months (TTM) ended in Mar. 2026 was €-50.1 Mil. Therefore, Macrogenics's EV-to-EBIT for today is -2.28.

The historical rank and industry rank for Macrogenics's EV-to-EBIT or its related term are showing as below:

FRA:M55' s EV-to-EBIT Range Over the Past 10 Years
Min: -129.36   Med: -2.59   Max: 18.38
Current: -2.28

During the past 13 years, the highest EV-to-EBIT of Macrogenics was 18.38. The lowest was -129.36. And the median was -2.59.

FRA:M55's EV-to-EBIT is ranked worse than
100% of 367 companies
in the Biotechnology industry
Industry Median: 15.96 vs FRA:M55: -2.28

Joel Greenblatt calls the inversion of this ratio Earnings Yield (Joel Greenblatt) %. Macrogenics's Enterprise Value for the quarter that ended in Mar. 2026 was €49.7 Mil. Macrogenics's EBIT for the trailing twelve months (TTM) ended in Mar. 2026 was €-50.1 Mil. Macrogenics's Earnings Yield (Joel Greenblatt) % for the quarter that ended in Mar. 2026 was -100.90%.


Macrogenics  (FRA:M55) EV-to-EBIT Explanation

This is a more accurate valuation of companies' operation because it considers the debt and cash on its balance sheet, and non-operating items such as interest payment, tax, and one-time items are not included in the Operating Income.

Joel Greenblatt calls the inversion of this ratio Earnings Yield (Joel Greenblatt) %.

Macrogenics's Earnings Yield (Joel Greenblatt) % for the quarter that ended in Mar. 2026 is calculated as:

Earnings Yield (Joel Greenblatt) % (Q: Mar. 2026 ) =EBIT / Enterprise Value (Q: Mar. 2026 )
=-50.148/49.69904
=-100.90 %

Macrogenics's Enterprise Value for the quarter that ended in Mar. 2026 was €49.7 Mil.
Macrogenics's EBIT for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was €-50.1 Mil.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.


Macrogenics EV-to-EBIT Related Terms


Macrogenics EV-to-EBIT Historical Data

* Premium members only.

The historical data trend for Macrogenics's EV-to-EBIT can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Macrogenics EV-to-EBIT Chart

Macrogenics Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
EV-to-EBIT
Get a 7-Day Free Trial Premium Member Only Premium Member Only -3.79 -2.46 -52.61 -0.62 0.77

Macrogenics Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
EV-to-EBIT Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 0.67 1.82 0.04 0.77 -1.14

FRA:M55 vs RNAC, CNXU, GALT: EV-to-EBIT Comparison

For the Biotechnology subindustry, Macrogenics's EV-to-EBIT, along with its competitors' market caps and EV-to-EBIT data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Macrogenics EV-to-EBIT vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Macrogenics's EV-to-EBIT distribution charts can be found below:

* The bar in red indicates where Macrogenics's EV-to-EBIT falls into.


FRA:M55
48GF Score
Macrogenics Inc FRA:M55
EV-to-EBIT is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Macrogenics EV-to-EBIT Calculation

Macrogenics's EV-to-EBIT for today is calculated as:

EV-to-EBIT=Enterprise Value (Today)/EBIT (TTM)
=114.123/-50.148
=-2.28

Macrogenics's current Enterprise Value is €114.1 Mil.
Macrogenics's EBIT for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was €-50.1 Mil.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about EV-to-EBIT →
What does a EV-to-EBIT of -2.28 mean?
Macrogenics (FRA:M55) has a EV-to-EBIT of -2.28 as of Aug. 12, 2026. EV to EBIT ratio is the inverse of Joel Greenblatt's earnings yield definition. View historical data on Macrogenics and its competitors. According to the industry distribution chart, Macrogenics ranks #999999 out of 367 companies in the Biotechnology industry.
Is Macrogenics' EV-to-EBIT too high?
Macrogenics' current EV-to-EBIT is -2.28. Based on the distribution chart, Macrogenics ranks #999999 out of 367 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Macrogenics has a GF Score™ of 48/100, reflecting its overall financial health beyond just this single metric.
How does Macrogenics' EV-to-EBIT compare to RNAC and CNXU?
According to the Biotechnology industry distribution chart, Macrogenics ranks #999999 out of 367 companies for EV-to-EBIT. This places Macrogenics in the lower half of its industry. The industry median EV-to-EBIT is 15.96. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-EBIT for a Biotechnology company?
The median EV-to-EBIT among Biotechnology companies is 15.96, based on 367 companies in the industry. Companies in the top quartile (top 25%) have a EV-to-EBIT significantly above this median, while those in the bottom quartile fall well below. However, EV-to-EBIT should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-EBIT mean?
A high EV-to-EBIT can signal that a stock is expensive relative to its fundamentals. EV to EBIT ratio is the inverse of Joel Greenblatt's earnings yield definition. View historical data on Macrogenics and its competitors. For the Biotechnology industry, the median EV-to-EBIT is 15.96 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Macrogenics's current EV-to-EBIT is -2.28. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Macrogenics stock overvalued right now?
Macrogenics (FRA:M55) has a current EV-to-EBIT of -2.28. The stock's GF Value™ is €3.13, compared to a current price of €3.52 — trading 12.5% above its estimated fair value. The current EV-to-EBIT is -2.28. Macrogenics' overall GF Score™ is 48/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-EBIT calculated?
EV-to-EBIT is calculated from a company's financial statements. For Macrogenics (FRA:M55), the current EV-to-EBIT is -2.28 as of Aug. 12, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Macrogenics (FRA:M55) Overvalued in 2026?

Based on GuruFocus' analysis, Macrogenics stock appears to be overvalued. The current stock price of €3.52 is trading 12.5% above its estimated GF Value™ of €3.13.

Key valuation signals for FRA:M55:

  • EV-to-EBIT: -2.28
  • GF Value™: €3.13 vs. price of €3.52 (12.5% above fair value)
  • GF Score™: 48/100 with 5 warning signs

No single metric tells the full story. See the FRA:M55 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Macrogenics Business Description

Other Exchanges MGNX:USA
Address 9704 Medical Center Drive, Rockville, MD, USA, 20850
Macrogenics Inc is a clinical-stage biopharmaceutical company focused on developing antibody-based therapeutics for the treatment of cancer. The company is currently developing therapeutics utilizing multiple modalities, including antibody-drug conjugates (ADCs) and multi-specific antibodies (which it refers to as DART and TRIDENT molecules). It is advancing three proprietary product candidates in clinical development: lorigerlimab, a bispecific DART molecule that targets checkpoint inhibitors PD-1 and CTLA-4; MGC026, an ADC that targets B7-H3 and delivers a novel topoisomerase I inhibitor (TOP1i)-based linker-payload, and MGC028, an ADC that targets ADAM9 and delivers a novel TOP1i-based linker-payload. Its segment is developing and commercializing monoclonal antibody-based therapeutics.
48GF Score

Get the complete analysis for FRA:M55

EV-to-EBIT is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

€3.52
Price
€3.13
GF Value