PRAX (Praxis Precision Medicines) EV-to-EBIT: -21.84 (As of Aug. 03, 2026)

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PRAX Praxis Precision Medicines Inc PRAX
38 GF Score
Price $308.04
GF Value $23.94
Valuation Significantly Overvalued
! 2 Warning Signs
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What is Praxis Precision Medicines EV-to-EBIT?

Praxis Precision Medicines PRAX +0.15% 38 EV-to-EBIT is -21.84 as of Aug. 03, 2026. GuruFocus rates PRAX with a GF Score™ of 38/100 and a GF Value™ of $23.94 (Significantly Overvalued). The stock has 2 warning signs investors should review. Among 387 Biotechnology companies, Praxis Precision Medicines ranks worse than 258397.67% on this metric.

EV-to-EBIT is calculated as Enterprise Value divided by its EBIT. As of today, Praxis Precision Medicines's Enterprise Value is $7,802.35 Mil. Praxis Precision Medicines's EBIT for the trailing twelve months (TTM) ended in Mar. 2026 was $-357.33 Mil. Therefore, Praxis Precision Medicines's EV-to-EBIT for today is -21.84.

The historical rank and industry rank for Praxis Precision Medicines's EV-to-EBIT or its related term are showing as below:

PRAX' s EV-to-EBIT Range Over the Past 10 Years
Min: -25.33   Med: -3.25   Max: 0.34
Current: -21.84

During the past 8 years, the highest EV-to-EBIT of Praxis Precision Medicines was 0.34. The lowest was -25.33. And the median was -3.25.

PRAX's EV-to-EBIT is ranked worse than
100% of 387 companies
in the Biotechnology industry
Industry Median: 12.63 vs PRAX: -21.84

Joel Greenblatt calls the inversion of this ratio Earnings Yield (Joel Greenblatt) %. Praxis Precision Medicines's Enterprise Value for the quarter that ended in Mar. 2026 was $8,190.78 Mil. Praxis Precision Medicines's EBIT for the trailing twelve months (TTM) ended in Mar. 2026 was $-357.33 Mil. Praxis Precision Medicines's Earnings Yield (Joel Greenblatt) % for the quarter that ended in Mar. 2026 was -4.36%.


Praxis Precision Medicines  (NAS:PRAX) EV-to-EBIT Explanation

This is a more accurate valuation of companies' operation because it considers the debt and cash on its balance sheet, and non-operating items such as interest payment, tax, and one-time items are not included in the Operating Income.

Joel Greenblatt calls the inversion of this ratio Earnings Yield (Joel Greenblatt) %.

Praxis Precision Medicines's Earnings Yield (Joel Greenblatt) % for the quarter that ended in Mar. 2026 is calculated as:

Earnings Yield (Joel Greenblatt) % (Q: Mar. 2026 ) =EBIT / Enterprise Value (Q: Mar. 2026 )
=-357.33/8190.7834
=-4.36 %

Praxis Precision Medicines's Enterprise Value for the quarter that ended in Mar. 2026 was $8,190.78 Mil.
Praxis Precision Medicines's EBIT for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-357.33 Mil.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.


Praxis Precision Medicines EV-to-EBIT Related Terms


Praxis Precision Medicines EV-to-EBIT Historical Data

* Premium members only.

The historical data trend for Praxis Precision Medicines's EV-to-EBIT can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Praxis Precision Medicines EV-to-EBIT Chart

Praxis Precision Medicines Annual Data
Trend Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
EV-to-EBIT
Get a 7-Day Free Trial -3.71 -0.10 -0.93 -5.51 -20.93

Praxis Precision Medicines Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
EV-to-EBIT Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -1.90 -2.15 -2.92 -20.93 -22.92

PRAX vs KYMR, SYRE, CRNX: EV-to-EBIT Comparison

For the Biotechnology subindustry, Praxis Precision Medicines's EV-to-EBIT, along with its competitors' market caps and EV-to-EBIT data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Praxis Precision Medicines EV-to-EBIT vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Praxis Precision Medicines's EV-to-EBIT distribution charts can be found below:

* The bar in red indicates where Praxis Precision Medicines's EV-to-EBIT falls into.


PRAX
38GF Score
Praxis Precision Medicines Inc PRAX
EV-to-EBIT is just one metric. See GF Score™, valuation, warning signs, and more.
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Praxis Precision Medicines EV-to-EBIT Calculation

Praxis Precision Medicines's EV-to-EBIT for today is calculated as:

EV-to-EBIT=Enterprise Value (Today)/EBIT (TTM)
=7802.348/-357.33
=-21.84

Praxis Precision Medicines's current Enterprise Value is $7,802.35 Mil.
Praxis Precision Medicines's EBIT for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-357.33 Mil.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about EV-to-EBIT →
What does a EV-to-EBIT of -21.84 mean?
Praxis Precision Medicines (PRAX) has a EV-to-EBIT of -21.84 as of Aug. 03, 2026. EV to EBIT ratio is the inverse of Joel Greenblatt's earnings yield definition. View historical data on Praxis Precision Medicines and its competitors. According to the industry distribution chart, Praxis Precision Medicines ranks #999999 out of 387 companies in the Biotechnology industry.
Is Praxis Precision Medicines' EV-to-EBIT too high?
Praxis Precision Medicines' current EV-to-EBIT is -21.84. Based on the distribution chart, Praxis Precision Medicines ranks #999999 out of 387 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Praxis Precision Medicines has a GF Score™ of 38/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Praxis Precision Medicines' EV-to-EBIT compare to KYMR and SYRE?
According to the Biotechnology industry distribution chart, Praxis Precision Medicines ranks #999999 out of 387 companies for EV-to-EBIT. This places Praxis Precision Medicines in the lower half of its industry. The industry median EV-to-EBIT is 12.63. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-EBIT for a Biotechnology company?
The median EV-to-EBIT among Biotechnology companies is 12.63, based on 387 companies in the industry. Companies in the top quartile (top 25%) have a EV-to-EBIT significantly above this median, while those in the bottom quartile fall well below. However, EV-to-EBIT should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-EBIT mean?
A high EV-to-EBIT can signal that a stock is expensive relative to its fundamentals. EV to EBIT ratio is the inverse of Joel Greenblatt's earnings yield definition. View historical data on Praxis Precision Medicines and its competitors. For the Biotechnology industry, the median EV-to-EBIT is 12.63 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Praxis Precision Medicines's current EV-to-EBIT is -21.84. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Praxis Precision Medicines stock overvalued right now?
Based on GuruFocus' analysis, Praxis Precision Medicines (PRAX) is currently considered Significantly Overvalued. The stock's GF Value™ is $23.94, compared to a current price of $308.04 — trading 1186.7% above its estimated fair value. The current EV-to-EBIT is -21.84. Praxis Precision Medicines' overall GF Score™ is 38/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-EBIT calculated?
EV-to-EBIT is calculated from a company's financial statements. For Praxis Precision Medicines (PRAX), the current EV-to-EBIT is -21.84 as of Aug. 03, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Praxis Precision Medicines (PRAX) Overvalued in 2026?

Based on GuruFocus' analysis, Praxis Precision Medicines stock appears to be overvalued. The current stock price of $308.04 is trading 1186.7% above its estimated GF Value™ of $23.94. GuruFocus considers Praxis Precision Medicines to be Significantly Overvalued.

Key valuation signals for PRAX:

  • EV-to-EBIT: -21.84
  • GF Value™: $23.94 vs. price of $308.04 (1186.7% above fair value)
  • GF Score™: 38/100 with 2 warning signs

No single metric tells the full story. See the PRAX stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Praxis Precision Medicines Business Description

Address 99 High Street, 30th Floor, Boston, MA, USA, 02110
Praxis Precision Medicines Inc is a clinical-stage biopharmaceutical company. It is engaged in translating genetic insights into the development of therapies for patients affected by central nervous system disorders characterized by a neuronal excitation-inhibition imbalance. The company applies genetic insights to the discovery and development of therapies for neurological disorders through two proprietary platforms: Cerebrum and Solidus. It has established a diversified, multimodal CNS portfolio with four clinical-stage product candidates across movement disorders and epilepsy, which include Ulixacaltamide, Relutrigine, Vormatrigine, and Elsunersen. The firm operates in only one segment and is focused on discovering and developing therapies for CNS disorders.
38GF Score

Get the complete analysis for PRAX

EV-to-EBIT is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$308.04
Price
$23.94
GF Value