Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.
EV-to-EBITDA is calculated as enterprise value divided by its EBITDA. As of today, Bicycle Therapeutics's enterprise value is €-208.35 Mil.
Bicycle Therapeutics's EBITDA for the trailing twelve months (TTM) ended in Jun. 2026 was €-157.68 Mil. Therefore, Bicycle Therapeutics's EV-to-EBITDA for today is 1.32.
The historical rank and industry rank for Bicycle Therapeutics's EV-to-EBITDA or its related term are showing as below:
FRA:50BA'
s EV-to-EBITDA Range Over the Past 10 Years
Min: -21.48 Med: -3.47 Max: 2.28
Current: 1.24
During the past 9 years, the highest EV-to-EBITDA of Bicycle Therapeutics was 2.28. The lowest was -21.48. And the median was -3.47.
FRA:50BA's EV-to-EBITDA is ranked better than 76.16% of 411
companies
in the Biotechnology industry
Industry Median: 12.78
vs FRA:50BA: 1.24
EV-to-EBITDA is a valuation multiple used in finance and investment to measure the value of a company. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio to determine the fair market value of a company.
EV-to-EBITDA is a valuation multiple used in finance and investment to measure the value of a company. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.
Bicycle Therapeutics's PE Ratio (TTM) for today is calculated as:
Bicycle Therapeutics's share price for today is €3.18.
Bicycle Therapeutics's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Jun. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was €-2.350.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Study has found that the companies with the lowest EV-to-EBITDA outperforms companies measured as cheap by other ratios such as PE Ratio (TTM).
The historical data trend for Bicycle Therapeutics's EV-to-EBITDA can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
FRA:50BA vs CYDY, ALXO, SABS: EV-to-EBITDA Comparison
For the Biotechnology subindustry, Bicycle Therapeutics's EV-to-EBITDA, along with its competitors' market caps and EV-to-EBITDA data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Bicycle Therapeutics EV-to-EBITDA vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Bicycle Therapeutics's EV-to-EBITDA distribution charts can be found below:
* The bar in red indicates where Bicycle Therapeutics's EV-to-EBITDA falls into.
Bicycle Therapeutics's current Enterprise Value is €-208.35 Mil.
Bicycle Therapeutics's EBITDA for the trailing twelve months (TTM) ended in Jun. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was €-157.68 Mil.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Bicycle Therapeutics (FRA:50BA) has a EV-to-EBITDA of 1.32 as of Aug. 05, 2026. EV to EBITDA ratio is the company's enterprise value divided by earnings before interest, taxes, depreciation and amortization. View historical data on Bicycle Therapeutics. According to the industry distribution chart, Bicycle Therapeutics ranks #98 out of 411 companies in the Biotechnology industry, placing it in the top 23.8%.
Is Bicycle Therapeutics' EV-to-EBITDA too high?
Bicycle Therapeutics' current EV-to-EBITDA is 1.32. The Biotechnology industry median EV-to-EBITDA is 12.78. Bicycle Therapeutics' value of 1.32 is 89.7% below this industry median. Based on the distribution chart, Bicycle Therapeutics ranks #98 out of 411 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers. Overall, Bicycle Therapeutics has a GF Score™ of 53/100 and is considered Possible Value Trap, reflecting its overall financial health beyond just this single metric.
How does Bicycle Therapeutics' EV-to-EBITDA compare to CYDY and ALXO?
According to the Biotechnology industry distribution chart, Bicycle Therapeutics ranks #98 out of 411 companies for EV-to-EBITDA. This places Bicycle Therapeutics in the top 24% of its industry — outperforming the majority of peers. The industry median EV-to-EBITDA is 12.78. Bicycle Therapeutics' value of 1.32 is 89.7% below this benchmark. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-EBITDA for a Biotechnology company?
The median EV-to-EBITDA among Biotechnology companies is 12.78, based on 411 companies in the industry. Companies in the top quartile (top 25%) have a EV-to-EBITDA significantly above this median, while those in the bottom quartile fall well below. However, EV-to-EBITDA should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Bicycle Therapeutics's current EV-to-EBITDA of 1.32 is 89.7% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-EBITDA mean?
A high EV-to-EBITDA can signal that a stock is expensive relative to its fundamentals. EV to EBITDA ratio is the company's enterprise value divided by earnings before interest, taxes, depreciation and amortization. View historical data on Bicycle Therapeutics. For the Biotechnology industry, the median EV-to-EBITDA is 12.78 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Bicycle Therapeutics's current EV-to-EBITDA is 1.32. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Bicycle Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Bicycle Therapeutics (FRA:50BA) is currently considered Possible Value Trap. The stock's GF Value™ is €12.61, compared to a current price of €3.18 — trading 74.8% below its estimated fair value. The current EV-to-EBITDA is 1.32 and 89.7% below the Biotechnology industry median of 12.78. Bicycle Therapeutics' overall GF Score™ is 53/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-EBITDA calculated?
EV-to-EBITDA is calculated from a company's financial statements. For Bicycle Therapeutics (FRA:50BA), the current EV-to-EBITDA is 1.32 as of Aug. 05, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Bicycle Therapeutics (FRA:50BA) Overvalued in 2026?
Based on GuruFocus' analysis, Bicycle Therapeutics stock appears to be undervalued.
The current stock price of €3.18 is trading 74.8% below its estimated GF Value™ of €12.61.
GuruFocus considers Bicycle Therapeutics to be Possible Value Trap.
Key valuation signals for FRA:50BA:
EV-to-EBITDA: 1.32
GF Value™: €12.61 vs. price of €3.18 (74.8% below fair value)
Industry Position: 89.7% below the Biotechnology median (#98 of 411)
No single metric tells the full story. See the FRA:50BA stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Bicycle Therapeutics PLC is a clinical-stage biopharmaceutical company developing a novel class of medicines which are referred to as Bicycles. The Bicycles are synthetic short peptides constrained to form two loops that stabilize their structural geometry. Its initial internal programs are focused on oncology indications with high unmet medical needs. The company's product candidate, BT1718, is a Bicycle Toxin Conjugate, or BTC. The company has two segments: the United Kingdom and the United States. It derives maximum revenue from United Kingdom.
53GF Score
Get the complete analysis for FRA:50BA
EV-to-EBITDA is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
Quick Browse
Personalize
Premium Gurus 
Create New Portfolio
FRA:50BA has been successfully added to your 
