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IlluminaWBO:ILMN +0.52%67 EV-to-EBITDA is 22.07 as of Jul. 30, 2026, which is 18% below its 10-year median of 26.88. GuruFocus rates WBO:ILMN with a GF Score™ of 67/100 and a GF Value™ of €113.05 (Significantly Overvalued). The stock has 7 warning signs investors should review. Among 119 Medical Diagnostics & Research companies, Illumina ranks worse than 65.55% on this metric.
EV-to-EBITDA is calculated as enterprise value divided by its EBITDA. As of today, Illumina's enterprise value is €27,108 Mil.
Illumina's EBITDA for the trailing twelve months (TTM) ended in Mar. 2026 was €1,229 Mil. Therefore, Illumina's EV-to-EBITDA for today is 22.07.
The historical rank and industry rank for Illumina's EV-to-EBITDA or its related term are showing as below:
WBO:ILMN'
s EV-to-EBITDA Range Over the Past 10 Years
Min: -38.41 Med: 26.88 Max: 91.5
Current: 21.58
During the past 13 years, the highest EV-to-EBITDA of Illumina was 91.50. The lowest was -38.41. And the median was 26.88.
WBO:ILMN's EV-to-EBITDA is ranked worse than 65.55% of 119
companies
in the Medical Diagnostics & Research industry
Industry Median: 15.25
vs WBO:ILMN: 21.58
EV-to-EBITDA is a valuation multiple used in finance and investment to measure the value of a company. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio to determine the fair market value of a company.
The "classic" EV-to-EBITDA is much better in capturing debt and net cash than the PE Ratio (TTM).
Illumina (WBO:ILMN) EV-to-EBITDA Explanation
EV-to-EBITDA is a valuation multiple used in finance and investment to measure the value of a company. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.
Illumina's share price for today is €169.62.
Illumina's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was €4.725.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Study has found that the companies with the lowest EV-to-EBITDA outperforms companies measured as cheap by other ratios such as PE Ratio (TTM).
The historical data trend for Illumina's EV-to-EBITDA can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
For the Diagnostics & Research subindustry, Illumina's EV-to-EBITDA, along with its competitors' market caps and EV-to-EBITDA data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Illumina EV-to-EBITDA vs Medical Diagnostics & Research Industry
For the Medical Diagnostics & Research industry and Healthcare sector, Illumina's EV-to-EBITDA distribution charts can be found below:
* The bar in red indicates where Illumina's EV-to-EBITDA falls into.
Illumina's current Enterprise Value is €27,108 Mil.
Illumina's EBITDA for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was €1,229 Mil.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Illumina (WBO:ILMN) has a EV-to-EBITDA of 22.07 as of Jul. 30, 2026. EV to EBITDA ratio is the company's enterprise value divided by earnings before interest, taxes, depreciation and amortization. View historical data on Illumina. This is 18% below median its historical median of 26.88. According to the industry distribution chart, Illumina ranks #78 out of 119 companies in the Medical Diagnostics & Research industry, placing it in the top 65.5%.
Is Illumina's EV-to-EBITDA too high?
Illumina's current EV-to-EBITDA of 22.07 is 18% below median its 10-year median of 26.88. The Medical Diagnostics & Research industry median EV-to-EBITDA is 15.25. Illumina's value of 22.07 is 44.7% above this industry median. Based on the distribution chart, Illumina ranks #78 out of 119 companies in the Medical Diagnostics & Research industry, which is below the industry midpoint. Overall, Illumina has a GF Score™ of 67/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Illumina's EV-to-EBITDA compare to MTD and DGX?
According to the Medical Diagnostics & Research industry distribution chart, Illumina ranks #78 out of 119 companies for EV-to-EBITDA. This places Illumina in the lower half of its industry. The industry median EV-to-EBITDA is 15.25. Illumina's value of 22.07 is 44.7% above this benchmark. While the company's 10-year median is 26.88 vs. the industry median of 15.25, Illumina has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-EBITDA for a Medical Diagnostics & Research company?
The median EV-to-EBITDA among Medical Diagnostics & Research companies is 15.25, based on 119 companies in the industry. Companies in the top quartile (top 25%) have a EV-to-EBITDA significantly above this median, while those in the bottom quartile fall well below. However, EV-to-EBITDA should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Illumina's current EV-to-EBITDA of 22.07 is 44.7% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-EBITDA mean?
A high EV-to-EBITDA can signal that a stock is expensive relative to its fundamentals. EV to EBITDA ratio is the company's enterprise value divided by earnings before interest, taxes, depreciation and amortization. View historical data on Illumina. For the Medical Diagnostics & Research industry, the median EV-to-EBITDA is 15.25 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Illumina's current EV-to-EBITDA is 22.07, which is 18% below median its own 10-year median of 26.88. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Illumina stock overvalued right now?
Based on GuruFocus' analysis, Illumina (WBO:ILMN) is currently considered Significantly Overvalued. The stock's GF Value™ is €113.05, compared to a current price of €169.62 — trading 50% above its estimated fair value. The current EV-to-EBITDA is 22.07, which is 18% below median its 10-year median of 26.88 and 44.7% above the Medical Diagnostics & Research industry median of 15.25. Illumina's overall GF Score™ is 67/100 with 7 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-EBITDA calculated?
EV-to-EBITDA is calculated from a company's financial statements. For Illumina (WBO:ILMN), the current EV-to-EBITDA is 22.07 as of Jul. 30, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Illumina (WBO:ILMN) Overvalued in 2026?
Based on GuruFocus' analysis, Illumina stock appears to be overvalued.
The current stock price of €169.62 is trading 50% above its estimated GF Value™ of €113.05.
GuruFocus considers Illumina to be Significantly Overvalued.
Key valuation signals for WBO:ILMN:
EV-to-EBITDA: 22.07 (18% below median its 10-year median of 26.88)
GF Value™: €113.05 vs. price of €169.62 (50% above fair value)
Industry Position: 44.7% above the Medical Diagnostics & Research median (#78 of 119)
No single metric tells the full story. See the WBO:ILMN stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Illumina provides tools and services to analyze genetic material with life science and clinical lab applications. The company generates over 90% of its revenue from sequencing instruments, consumables, and services. Illumina's high-throughput technology enables whole genome sequencing in humans and other large organisms. Its lower throughput tools enable applications that require smaller data outputs, such as viral and cancer tumor screening. Illumina also sells microarrays (9% of 2024 sales) that enable lower-cost, focused genetic screening with primarily consumer and agricultural applications.
67GF Score
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