HOWL (Werewolf Therapeutics) EV-to-OCF: 0.11 (As of Aug. 10, 2026) — 120% Above Median

Author: Vera Yuan Vera Yuan
Vera Yuan
Vera Yuan
Director of Data and Quant Analytics at GuruFocus
Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Reviewed by: Charlie Tian Charlie Tian
Charlie Tian
Charlie Tian
Founder & CEO of GuruFocus
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.

HOWL Werewolf Therapeutics Inc HOWL
32 GF Score
Price $0.38
GF Value $3.78
Valuation Possible Value Trap
! 2 Warning Signs
View Full Analysis

What is Werewolf Therapeutics EV-to-OCF?

Werewolf Therapeutics HOWL -4.02% 32 EV-to-OCF is 0.11 as of Aug. 10, 2026, which is 120% above its 10-year median of 0.05. GuruFocus rates HOWL with a GF Score™ of 32/100 and a GF Value™ of $3.78 (Possible Value Trap). The stock has 2 warning signs investors should review. Among 1,405 Biotechnology companies, Werewolf Therapeutics ranks worse than 73.17% on this metric.

EV-to-OCF is calculated as enterprise value divided by its cash flow from operations. As of today, Werewolf Therapeutics's Enterprise Value is $-3.42 Mil. Werewolf Therapeutics's Cash Flow from Operations for the trailing twelve months (TTM) ended in Jun. 2026 was $-30.15 Mil. Therefore, Werewolf Therapeutics's EV-to-OCF for today is 0.11.

The historical rank and industry rank for Werewolf Therapeutics's EV-to-OCF or its related term are showing as below:

HOWL' s EV-to-OCF Range Over the Past 10 Years
Min: -5.76   Med: 0.05   Max: 1.75
Current: 0.11

During the past 7 years, the highest EV-to-OCF of Werewolf Therapeutics was 1.75. The lowest was -5.76. And the median was 0.05.

HOWL's EV-to-OCF is ranked worse than
73.17% of 1405 companies
in the Biotechnology industry
Industry Median: -3.45 vs HOWL: 0.11

EV-to-OCF is a valuation multiple that allows analysts and investors to compare stocks, preferably in the same sector or industry. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.

As of today (2026-08-10), Werewolf Therapeutics's stock price is $0.382. Werewolf Therapeutics's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Jun. 2026 was $-0.760. Therefore, Werewolf Therapeutics's PE Ratio (TTM) for today is At Loss.


Werewolf Therapeutics  (NAS:HOWL) EV-to-OCF Explanation

EV-to-OCF is a valuation multiple that allows analysts and investors to compare stocks, preferably in the same sector or industry. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.

Werewolf Therapeutics's PE Ratio (TTM) for today is calculated as:

PE Ratio (TTM)=Share Price (Today)/Earnings per Share (Diluted) (TTM)
=0.382/-0.760
=At Loss

Werewolf Therapeutics's share price for today is $0.382.
Werewolf Therapeutics's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Jun. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-0.760.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Enterprise Value is used because it is a more complete measure in reflecting how much an investor pays when buying a company. Cash Flow from Operations is an important financial metric because it represents the cash generated from operating activities at a company's disposal. Companies with a low EV-to-OCF ratio, combined with a strong balance sheet are generally considered as undervalued.


Werewolf Therapeutics EV-to-OCF Related Terms


Werewolf Therapeutics EV-to-OCF Historical Data

* Premium members only.

The historical data trend for Werewolf Therapeutics's EV-to-OCF can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Werewolf Therapeutics EV-to-OCF Chart

Werewolf Therapeutics Annual Data
Trend Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
EV-to-OCF
Get a 7-Day Free Trial -4.28 1.24 -2.10 0.13 -0.19

Werewolf Therapeutics Quarterly Data
Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26 Jun26
EV-to-OCF Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -0.15 -1.02 -0.19 -0.61 0.15

HOWL vs CVM, MRKR, ZIVO: EV-to-OCF Comparison

For the Biotechnology subindustry, Werewolf Therapeutics's EV-to-OCF, along with its competitors' market caps and EV-to-OCF data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Werewolf Therapeutics EV-to-OCF vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Werewolf Therapeutics's EV-to-OCF distribution charts can be found below:

* The bar in red indicates where Werewolf Therapeutics's EV-to-OCF falls into.


HOWL
32GF Score
Werewolf Therapeutics Inc HOWL
EV-to-OCF is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Werewolf Therapeutics EV-to-OCF Calculation

Werewolf Therapeutics's EV-to-OCF for today is calculated as:

EV-to-OCF=Enterprise Value (Today)/Cash Flow from Operations (TTM)
=-3.422/-30.148
=0.11

Werewolf Therapeutics's current Enterprise Value is $-3.42 Mil.
Werewolf Therapeutics's Cash Flow from Operations for the trailing twelve months (TTM) ended in Jun. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-30.15 Mil.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about EV-to-OCF →
What does a EV-to-OCF of 0.11 mean?
Werewolf Therapeutics (HOWL) has a EV-to-OCF of 0.11 as of Aug. 10, 2026. This is 120% above median its historical median of 0.05. According to the industry distribution chart, Werewolf Therapeutics ranks #1028 out of 1405 companies in the Biotechnology industry, placing it in the top 73.2%.
Is Werewolf Therapeutics' EV-to-OCF too high?
Werewolf Therapeutics' current EV-to-OCF of 0.11 is 120% above median its 10-year median of 0.05. Based on the distribution chart, Werewolf Therapeutics ranks #1028 out of 1405 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Werewolf Therapeutics has a GF Score™ of 32/100 and is considered Possible Value Trap, reflecting its overall financial health beyond just this single metric.
How does Werewolf Therapeutics' EV-to-OCF compare to CVM and MRKR?
According to the Biotechnology industry distribution chart, Werewolf Therapeutics ranks #1028 out of 1405 companies for EV-to-OCF. This places Werewolf Therapeutics in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-OCF for a Biotechnology company?
A good EV-to-OCF depends on the Biotechnology industry context. However, EV-to-OCF should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-OCF mean?
A high EV-to-OCF can signal that a stock is expensive relative to its fundamentals. Werewolf Therapeutics's current EV-to-OCF is 0.11, which is 120% above median its own 10-year median of 0.05. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Werewolf Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Werewolf Therapeutics (HOWL) is currently considered Possible Value Trap. The stock's GF Value™ is $3.78, compared to a current price of $0.38 — trading 89.9% below its estimated fair value. The current EV-to-OCF is 0.11, which is 120% above median its 10-year median of 0.05. Werewolf Therapeutics' overall GF Score™ is 32/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-OCF calculated?
EV-to-OCF is calculated from a company's financial statements. For Werewolf Therapeutics (HOWL), the current EV-to-OCF is 0.11 as of Aug. 10, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Werewolf Therapeutics (HOWL) Overvalued in 2026?

Based on GuruFocus' analysis, Werewolf Therapeutics stock appears to be undervalued. The current stock price of $0.38 is trading 89.9% below its estimated GF Value™ of $3.78. GuruFocus considers Werewolf Therapeutics to be Possible Value Trap.

Key valuation signals for HOWL:

  • EV-to-OCF: 0.11 (120% above median its 10-year median of 0.05)
  • GF Value™: $3.78 vs. price of $0.38 (89.9% below fair value)
  • GF Score™: 32/100 with 2 warning signs

No single metric tells the full story. See the HOWL stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Werewolf Therapeutics Business Description

Address 200 Talcott Avenue, 2nd Floor, Watertown, MA, USA, 02472
Werewolf Therapeutics Inc is a biopharmaceutical company pioneering the development of therapeutics engineered to stimulate the body's immune system for the treatment of cancer and other immune-mediated conditions. It is leveraging the proprietary PREDATOR platform to design conditionally activated molecules that stimulate both adaptive and innate immunity with the goal of addressing the limitations of conventional proinflammatory immune therapies. It has one reportable segment, which focuses on the discovery and development of cancer therapeutics.
32GF Score

Get the complete analysis for HOWL

EV-to-OCF is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$0.38
Price
$3.78
GF Value