Prothena (STU:0PT) Moat Score: 5/10 (As of Jul. 12, 2026)


STU:0PT Prothena Corp PLC STU:0PT
74 GF Score
Price €8.13
GF Value €12.89
! 3 Warning Signs
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What is Prothena Moat Score?

Prothena STU:0PT -3.44% 74 Moat Score is 5 as of Jul. 12, 2026. GuruFocus rates STU:0PT with a GF Score™ of 74/100 and a GF Value™ of €12.89. The stock has 3 warning signs investors should review. Among 1,396 Biotechnology companies, Prothena ranks better than 96.7% on this metric.

Prothena has the Moat Score of 5, which implies that the company might have Narrow Moat - Solid narrow moat.

Prothena has Narrow Moat: Prothena Corp PLC has valuable intellectual property and strong R&D capabilities in biotechnology. While it lacks significant market share and brand strength, its innovation and patents provide a solid narrow moat.

Moat Score is a ranking system developed by GuruFocus to assess a company's ability to sustain a competitive advantage, rated on a scale from 0 to 10. It takes into account key factors such as market leadership, cost advantages, network effects, customer switching costs, and more.

The company's Moat Score is based on these criteria:

1. Market leadership and sustainable market share
2. Network effects and significant customer switching costs
3. Valuable intellectual property and patents
4. Strong brand strength and deep customer loyalty
5. Durable cost advantages (e.g., economies of scale, proprietary technology)
6. Significant regulatory barriers and exclusive licenses
7. Superior distribution network
8. Strong and sustainable pricing power
9. Consistent and impactful innovation and R&D capabilities

Based on the research, GuruFocus believes Prothena might have Narrow Moat - Solid narrow moat.

Prothena  (STU:0PT) Moat Score Explanation

The Moat Score ranges from 0 to 10, with 10 as the highest. GuruFocus divided Moat Score into following 8 categories:

Moat Score Moat Level
10Wide Moat - Exceptionally dominant and durable wide moat
8 - 9Wide Moat - Clear and robust wide moat
7Wide Moat - Entry-level wide moat, clearly possessing durable advantages
6Narrow Moat - Strong narrow moat, clearly distinguishable but not wide
5Narrow Moat - Solid narrow moat
4Narrow Moat - Discernible but modest moat
1 - 3No Moat - Very weak/transient advantages
0No Moat - No discernible moat

Prothena Moat Score Related Terms

STU:0PT vs CTNM, ASMB, ARVN: Moat Score Comparison

For the Biotechnology subindustry, Prothena's Moat Score, along with its competitors' market caps and Moat Score data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.

Prothena Moat Score vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Prothena's Moat Score distribution charts can be found below:

* The bar in red indicates where Prothena's Moat Score falls into.


STU:0PT
74GF Score
Prothena Corp PLC STU:0PT
Moat Score is just one metric. See GF Score™, valuation, warning signs, and more.
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Frequently Asked Questions Learn more about Moat Score →
What does a Moat Score of 5 mean?
Prothena (STU:0PT) has a Moat Score of 5 as of Jul. 12, 2026. Moat Score is a ranking system developed by GuruFocus to assess a company's ability to sustain a competitive advantage, rated on a scale from 0 to 10. It takes into account key factors such as market leadership, cost advantages, network effects, customer switching costs, and more. According to the industry distribution chart, Prothena ranks #46 out of 1396 companies in the Biotechnology industry, placing it in the top 3.3%.
Is Prothena's Moat Score too high?
Prothena's current Moat Score is 5. The Biotechnology industry median Moat Score is 2.00. Prothena's value of 5 is 150% above this industry median. Based on the distribution chart, Prothena ranks #46 out of 1396 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers. Overall, Prothena has a GF Score™ of 74/100, reflecting its overall financial health beyond just this single metric.
How does Prothena's Moat Score compare to CTNM and ASMB?
According to the Biotechnology industry distribution chart, Prothena ranks #46 out of 1396 companies for Moat Score. This places Prothena in the top 3% of its industry — outperforming the majority of peers. The industry median Moat Score is 2.00. Prothena's value of 5 is 150% above this benchmark. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Moat Score for a Biotechnology company?
The median Moat Score among Biotechnology companies is 2.00, based on 1,396 companies in the industry. Companies in the top quartile (top 25%) have a Moat Score significantly above this median, while those in the bottom quartile fall well below. However, Moat Score should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Prothena's current Moat Score of 5 is 150% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Moat Score mean?
A high Moat Score can signal that a stock is expensive relative to its fundamentals. Moat Score is a ranking system developed by GuruFocus to assess a company's ability to sustain a competitive advantage, rated on a scale from 0 to 10. It takes into account key factors such as market leadership, cost advantages, network effects, customer switching costs, and more. For the Biotechnology industry, the median Moat Score is 2.00 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Prothena's current Moat Score is 5. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Prothena stock overvalued right now?
Prothena (STU:0PT) has a current Moat Score of 5. The stock's GF Value™ is €12.89, compared to a current price of €8.13 — trading 36.9% below its estimated fair value. The current Moat Score is 5 and 150% above the Biotechnology industry median of 2.00. Prothena's overall GF Score™ is 74/100 with 3 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Moat Score calculated?
Moat Score is calculated from a company's financial statements. For Prothena (STU:0PT), the current Moat Score is 5 as of Jul. 12, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Prothena (STU:0PT) Overvalued in 2026?

Based on GuruFocus' analysis, Prothena stock appears to be undervalued. The current stock price of €8.13 is trading 36.9% below its estimated GF Value™ of €12.89.

Key valuation signals for STU:0PT:

  • Moat Score: 5
  • GF Value™: €12.89 vs. price of €8.13 (36.9% below fair value)
  • GF Score™: 74/100 with 3 warning signs
  • Industry Position: 150% above the Biotechnology median (#46 of 1396)

No single metric tells the full story. See the STU:0PT stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.

Prothena Business Description

Other Exchanges PRTA:USA0Y3M:UK0PT:Germany
Address 77 Sir John Rogerson’s Quay, Block C, Grand Canal Docklands, Dublin 2, Dublin, IRL, D02 VK60
Prothena Corp PLC is a late-stage clinical biotechnology company that focuses on protein dysregulation and a pipeline of investigational therapeutics with the potential to change the course of devastating neurodegenerative and rare and peripheral amyloid diseases. Prothena is developing and applying its proprietary CYTOPE technology to target a broad spectrum of intracellular disease pathways in the brain and periphery. The company's pipeline includes both wholly-owned and partnered programs like Prasinezumab, Coramitug (PRX004), BMS-986446 (PRX005), PRX019, TDP-43 CYTOPE, and PRX012-TfR, being developed for the potential treatment of Parkinson's disease, ATTR amyloidosis with cardiomyopathy, Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), and other neurodegenerative diseases.
74GF Score

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Moat Score is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

€8.13
Price
€12.89
GF Value