SPHDF (Santhera Pharmaceuticals Holding AG) OCF Margin %: -26.64% (As of Dec. 2025)


SPHDF Santhera Pharmaceuticals Holding AG SPHDF
39 GF Score
Price $23.25
GF Value $24.73
Valuation Fairly Valued
! 7 Warning Signs
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What is Santhera Pharmaceuticals Holding AG OCF Margin %?

Santhera Pharmaceuticals Holding AG SPHDF 39 OCF Margin % is -26.64% as of Dec. 2025. GuruFocus rates SPHDF with a GF Score™ of 39/100 and a GF Value™ of $24.73 (Fairly Valued). The stock has 7 warning signs investors should review. Among 959 Biotechnology companies, Santhera Pharmaceuticals Holding AG ranks better than 53.08% on this metric.

OCF Margin % is calculated as Cash Flow from Operations divided by its Revenue. Santhera Pharmaceuticals Holding AG's Cash Flow from Operations for the six months ended in Dec. 2025 was $-17.78 Mil. Santhera Pharmaceuticals Holding AG's Revenue for the six months ended in Dec. 2025 was $66.72 Mil. Therefore, Santhera Pharmaceuticals Holding AG's OCF Margin % for the quarter that ended in Dec. 2025 was -26.64%.

As of today, Santhera Pharmaceuticals Holding AG's current OCF Yield % is -14.70%.

The historical rank and industry rank for Santhera Pharmaceuticals Holding AG's OCF Margin % or its related term are showing as below:

SPHDF' s OCF Margin % Range Over the Past 10 Years
Min: -399.34   Med: -105.22   Max: 2342.26
Current: -44.78


During the past 13 years, the highest OCF Margin % of Santhera Pharmaceuticals Holding AG was 2342.26%. The lowest was -399.34%. And the median was -105.22%.

SPHDF's OCF Margin % is ranked better than
53.08% of 959 companies
in the Biotechnology industry
Industry Median: -66.52 vs SPHDF: -44.78


Santhera Pharmaceuticals Holding AG OCF Margin % Related Terms


Santhera Pharmaceuticals Holding AG OCF Margin % Historical Data

* Premium members only.

The historical data trend for Santhera Pharmaceuticals Holding AG's OCF Margin % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Santhera Pharmaceuticals Holding AG OCF Margin % Chart

Santhera Pharmaceuticals Holding AG Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
OCF Margin %
Get a 7-Day Free Trial Premium Member Only Premium Member Only 2,342.03 -399.33 45.71 -90.82 -45.04

Santhera Pharmaceuticals Holding AG Semi-Annual Data
Jun16 Dec16 Jun17 Dec17 Jun18 Dec18 Jun19 Dec19 Jun20 Dec20 Jun21 Dec21 Jun22 Dec22 Jun23 Dec23 Jun24 Dec24 Jun25 Dec25
OCF Margin % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 62.96 -108.28 -80.96 -85.78 -26.64

SPHDF vs VRTX, REGN, ALNY: OCF Margin % Comparison

For the Biotechnology subindustry, Santhera Pharmaceuticals Holding AG's OCF Margin %, along with its competitors' market caps and OCF Margin % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Santhera Pharmaceuticals Holding AG OCF Margin % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Santhera Pharmaceuticals Holding AG's OCF Margin % distribution charts can be found below:

* The bar in red indicates where Santhera Pharmaceuticals Holding AG's OCF Margin % falls into.


SPHDF
39GF Score
Santhera Pharmaceuticals Holding AG SPHDF
OCF Margin % is just one metric. See GF Score™, valuation, warning signs, and more.
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Santhera Pharmaceuticals Holding AG OCF Margin % Calculation

OCF Margin % is the ratio of Cash Flow from Operations divided by net sales or Revenue, usually presented in percent.

Santhera Pharmaceuticals Holding AG's OCF Margin for the fiscal year that ended in Dec. 2025 is calculated as

OCF Margin=Cash Flow from Operations (A: Dec. 2025 )/Revenue (A: Dec. 2025 )
=-43.623/96.857
=-45.04 %

Santhera Pharmaceuticals Holding AG's OCF Margin for the quarter that ended in Dec. 2025 is calculated as

OCF Margin=Cash Flow from Operations (Q: Dec. 2025 )/Revenue (Q: Dec. 2025 )
=-17.775/66.724
=-26.64 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about OCF Margin % →
What does a OCF Margin % of -26.64% mean?
Santhera Pharmaceuticals Holding AG (SPHDF) has a OCF Margin % of -26.64% as of Dec. 2025. OCF Margin is the ratio of Cash Flow from Operations to Total Revenue. View historical data on Santhera Pharmaceuticals Holding AG and its competitors. According to the industry distribution chart, Santhera Pharmaceuticals Holding AG ranks #450 out of 959 companies in the Biotechnology industry, placing it in the top 46.9%.
Is Santhera Pharmaceuticals Holding AG's OCF Margin % too high?
Santhera Pharmaceuticals Holding AG's current OCF Margin % is -26.64%. Based on the distribution chart, Santhera Pharmaceuticals Holding AG ranks #450 out of 959 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Santhera Pharmaceuticals Holding AG has a GF Score™ of 39/100 and is considered Fairly Valued, reflecting its overall financial health beyond just this single metric.
How does Santhera Pharmaceuticals Holding AG's OCF Margin % compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Santhera Pharmaceuticals Holding AG ranks #450 out of 959 companies for OCF Margin %. This puts Santhera Pharmaceuticals Holding AG in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good OCF Margin % for a Biotechnology company?
A good OCF Margin % depends on the Biotechnology industry context. However, OCF Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high OCF Margin % mean?
A high OCF Margin % can signal that a stock is expensive relative to its fundamentals. OCF Margin is the ratio of Cash Flow from Operations to Total Revenue. View historical data on Santhera Pharmaceuticals Holding AG and its competitors. Santhera Pharmaceuticals Holding AG's current OCF Margin % is -26.64%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Santhera Pharmaceuticals Holding AG stock overvalued right now?
Based on GuruFocus' analysis, Santhera Pharmaceuticals Holding AG (SPHDF) is currently considered Fairly Valued. The stock's GF Value™ is $24.73, compared to a current price of $23.25 — trading 6% below its estimated fair value. The current OCF Margin % is -26.64%. Santhera Pharmaceuticals Holding AG's overall GF Score™ is 39/100 with 7 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is OCF Margin % calculated?
OCF Margin % is calculated from a company's financial statements. For Santhera Pharmaceuticals Holding AG (SPHDF), the current OCF Margin % is -26.64% as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Santhera Pharmaceuticals Holding AG (SPHDF) Overvalued in 2026?

Based on GuruFocus' analysis, Santhera Pharmaceuticals Holding AG stock appears to be undervalued. The current stock price of $23.25 is trading 6% below its estimated GF Value™ of $24.73. GuruFocus considers Santhera Pharmaceuticals Holding AG to be Fairly Valued.

Key valuation signals for SPHDF:

  • OCF Margin %: -26.64%
  • GF Value™: $24.73 vs. price of $23.25 (6% below fair value)
  • GF Score™: 39/100 with 7 warning signs

No single metric tells the full story. See the SPHDF stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Santhera Pharmaceuticals Holding AG Business Description

Address Hohenrainstrasse 24, Pratteln, CHE, 4133
Santhera Pharmaceuticals Holding AG is a Swiss specialty pharmaceutical company committed to developing and commercializing medicines to meet the needs of patients living with rare and other diseases with high unmet medical needs. It is focused on the development of treatments for pulmonary and neuromuscular diseases that currently lack treatment options. The company is currently engaged in the rollout of its AGAMREE (vamorolone) medicine for the treatment of Duchenne muscular dystrophy (DMD) globally. Santhera has one operating segment, namely the development and commercialization of products for the treatment of neuromuscular diseases. Geographically, the company generates maximum revenue from Europe, and the rest from Asia and North America.
39GF Score

Get the complete analysis for SPHDF

OCF Margin % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$23.25
Price
$24.73
GF Value