enGene Therapeutics (FRA:S0N0) Operating Margin %: 0.00% (As of Apr. 2026)

Author: Vera Yuan Vera Yuan
Vera Yuan
Vera Yuan
Director of Data and Quant Analytics at GuruFocus
Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Reviewed by: Charlie Tian Charlie Tian
Charlie Tian
Charlie Tian
Founder & CEO of GuruFocus
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.

FRA:S0N0 enGene Therapeutics Inc FRA:S0N0
19 GF Score
Price €1.43
! 1 Warning Sign
View Full Analysis

What is enGene Therapeutics Operating Margin %?

enGene Therapeutics FRA:S0N0 -2.05% 19 Operating Margin % is 0.00% as of Apr. 2026. GuruFocus rates FRA:S0N0 with a GF Score™ of 19/100. The stock has 1 warning sign investors should review. Among 942 Biotechnology companies, enGene Therapeutics ranks worse than 106157.01% on this metric.

Operating Margin % is calculated as Operating Income divided by its Revenue. enGene Therapeutics's Operating Income for the three months ended in Apr. 2026 was €-27.33 Mil. enGene Therapeutics's Revenue for the three months ended in Apr. 2026 was €0.00 Mil. Therefore, enGene Therapeutics's Operating Margin % for the quarter that ended in Apr. 2026 was 0.00%.

The historical rank and industry rank for enGene Therapeutics's Operating Margin % or its related term are showing as below:


FRA:S0N0's Operating Margin % is not ranked *
in the Biotechnology industry.
Industry Median: -83.52
* Ranked among companies with meaningful Operating Margin % only.

enGene Therapeutics's 5-Year Average Operating Margin % Growth Rate was 0.00% per year.

enGene Therapeutics's Operating Income for the three months ended in Apr. 2026 was €-27.33 Mil. Its Operating Income for the trailing twelve months (TTM) ended in Apr. 2026 was €-113.45 Mil.


enGene Therapeutics  (FRA:S0N0) Operating Margin % Explanation

Just like Gross Margin %, it is important to see a company maintains its operating margin over time. Among the same industry, a company with higher operating margin is more efficient in its operation. It is also more stable during industry slowdown or recessions. Peter Lynch prefers those with higher margins than those with lower margins.


Be Aware

Operating Margin % can be manipulated by adjusting the rate of depreciation, depletion and amortization (DDA).

If a company is facing competition, its Operating Margin % may decline. Often the Operating Margin % declines well before the company's Revenue or even profit decline. Therefore, Operating Margin % is a very important indicator of whether the company is facing problems.

For instance, by 2012, Nokia (NOK)'s problems were well known and its stock had lost more than 90% of its market value since 2007. But Nokia’s Operating Margin % had already been in decline since 2002, although its Earnings per Share (Diluted) were still rising. Investors who paid attention to Operating Margin % would have avoided this huge loss. The same can be said for Research-in-Motion (RIMM).

Therefore, Operating Margin % is a very important screening filter for GuruFocus. GuruFocus's Buffett-Munger screener requires that the profit margin is either consistent or expanding. The Model Portfolio of the Buffett-Munger screener has outperformed the market every year since inception in 2009.


enGene Therapeutics Operating Margin % Related Terms


enGene Therapeutics Operating Margin % Historical Data

* Premium members only.

The historical data trend for enGene Therapeutics's Operating Margin % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

enGene Therapeutics Operating Margin % Chart

enGene Therapeutics Annual Data
Trend Oct20 Oct21 Oct22 Oct23 Oct24 Oct25
Operating Margin %
Get a 7-Day Free Trial 0.00 0.00 0.00 0.00 0.00

enGene Therapeutics Quarterly Data
Oct21 Apr22 Jul22 Oct22 Jan23 Apr23 Jul23 Oct23 Jan24 Apr24 Jul24 Oct24 Jan25 Apr25 Jul25 Oct25 Jan26 Apr26
Operating Margin % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 0.00 0.00 0.00 0.00 0.00

FRA:S0N0 vs VTVT, GUTS, VXRT: Operating Margin % Comparison

For the Biotechnology subindustry, enGene Therapeutics's Operating Margin %, along with its competitors' market caps and Operating Margin % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


enGene Therapeutics Operating Margin % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, enGene Therapeutics's Operating Margin % distribution charts can be found below:

* The bar in red indicates where enGene Therapeutics's Operating Margin % falls into.


FRA:S0N0
19GF Score
enGene Therapeutics Inc FRA:S0N0
Operating Margin % is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

enGene Therapeutics Operating Margin % Calculation

Operating Margin % - also known as operating income margin, operating profit margin and return on sales (ROS) - is the ratio of Operating Income divided by net sales or Revenue, usually presented in percent.

enGene Therapeutics's Operating Margin % for the fiscal year that ended in Oct. 2025 is calculated as

Operating Margin %=Operating Income (A: Oct. 2025 ) / Revenue (A: Oct. 2025 )
=-105.799 / 0
= %

enGene Therapeutics's Operating Margin % for the quarter that ended in Apr. 2026 is calculated as

Operating Margin %=Operating Income (Q: Apr. 2026 ) / Revenue (Q: Apr. 2026 )
=-27.333 / 0
= %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about Operating Margin % →
What does a Operating Margin % of 0.00% mean?
enGene Therapeutics (FRA:S0N0) has a Operating Margin % of 0.00% as of Apr. 2026. Operating margin is the ratio of total operating income to net sales. View historical data on enGene Therapeutics and its competitors. According to the industry distribution chart, enGene Therapeutics ranks #999999 out of 942 companies in the Biotechnology industry.
Is enGene Therapeutics' Operating Margin % too high?
enGene Therapeutics' current Operating Margin % is 0.00%. Based on the distribution chart, enGene Therapeutics ranks #999999 out of 942 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, enGene Therapeutics has a GF Score™ of 19/100, reflecting its overall financial health beyond just this single metric.
How does enGene Therapeutics' Operating Margin % compare to VTVT and GUTS?
According to the Biotechnology industry distribution chart, enGene Therapeutics ranks #999999 out of 942 companies for Operating Margin %. This places enGene Therapeutics in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Operating Margin % for a Biotechnology company?
A good Operating Margin % depends on the Biotechnology industry context. However, Operating Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Operating Margin % mean?
A high Operating Margin % can signal that a stock is expensive relative to its fundamentals. Operating margin is the ratio of total operating income to net sales. View historical data on enGene Therapeutics and its competitors. enGene Therapeutics's current Operating Margin % is 0.00%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is enGene Therapeutics stock overvalued right now?
enGene Therapeutics (FRA:S0N0) has a current Operating Margin % of 0.00%. The current Operating Margin % is 0.00%. enGene Therapeutics' overall GF Score™ is 19/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Operating Margin % calculated?
Operating Margin % is calculated from a company's financial statements. For enGene Therapeutics (FRA:S0N0), the current Operating Margin % is 0.00% as of Apr. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

enGene Therapeutics Business Description

Other Exchanges ENGN:USA
Address 4868 Rue Levy, Suite 220, Saint-Laurent, QC, CAN, H4R 2P1
enGene Therapeutics Inc is a clinical-stage biotechnology company mainstreaming gene therapy through the delivery of therapeutics to mucosal tissues and other organs, to create new ways to address diseases with high clinical needs. Its pioneering program is detalimogene voraplasmid (also known as detalimogene) for patients with Non-Muscle Invasive Bladder Cancer (NMIBC), a disease with a high clinical burden. Detalimogene is being evaluated in the ongoing multi-cohort LEGEND Phase 2 trial, which includes a pivotal cohort studying detalimogene in high-risk, Bacillus Calmette-Guerin (BCG)-unresponsive patients with carcinoma in situ (CIS) with or without concomitant papillary disease. It is developed using enGene's proprietary Dually Derivatized Oligochitosan (DDX) platform.
19GF Score

Get the complete analysis for FRA:S0N0

Operating Margin % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

€1.43
Price