GNI Group (TSE:2160) Operating Margin %: -49.75% (As of Mar. 2026)


TSE:2160 GNI Group Ltd TSE:2160
83 GF Score
Price 円2,507.00
GF Value 円2,777.01
Valuation Modestly Undervalued
! 5 Warning Signs
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What is GNI Group Operating Margin %?

GNI Group TSE:2160 -0.91% 83 Operating Margin % is -49.75% as of Mar. 2026. GuruFocus rates TSE:2160 with a GF Score™ of 83/100 and a GF Value™ of 円2,777.01 (Modestly Undervalued). The stock has 5 warning signs investors should review. Among 945 Biotechnology companies, GNI Group ranks better than 63.28% on this metric.

Operating Margin % is calculated as Operating Income divided by its Revenue. GNI Group's Operating Income for the three months ended in Mar. 2026 was 円-2,749 Mil. GNI Group's Revenue for the three months ended in Mar. 2026 was 円5,526 Mil. Therefore, GNI Group's Operating Margin % for the quarter that ended in Mar. 2026 was -49.75%.

The historical rank and industry rank for GNI Group's Operating Margin % or its related term are showing as below:

TSE:2160' s Operating Margin % Range Over the Past 10 Years
Min: -21.15   Med: 9.62   Max: 50.4
Current: -20.14


TSE:2160's Operating Margin % is ranked better than
63.28% of 945 companies
in the Biotechnology industry
Industry Median: -86.77 vs TSE:2160: -20.14

GNI Group's 5-Year Average Operating Margin % Growth Rate was 0.00% per year.

GNI Group's Operating Income for the three months ended in Mar. 2026 was 円-2,749 Mil. Its Operating Income for the trailing twelve months (TTM) ended in Mar. 2026 was 円-5,448 Mil.

Warning Sign:

GNI Group Ltd had lost money in 50% of the time over the past 12quarters.


GNI Group  (TSE:2160) Operating Margin % Explanation

Just like Gross Margin %, it is important to see a company maintains its operating margin over time. Among the same industry, a company with higher operating margin is more efficient in its operation. It is also more stable during industry slowdown or recessions. Peter Lynch prefers those with higher margins than those with lower margins.


Be Aware

Operating Margin % can be manipulated by adjusting the rate of depreciation, depletion and amortization (DDA).

If a company is facing competition, its Operating Margin % may decline. Often the Operating Margin % declines well before the company's Revenue or even profit decline. Therefore, Operating Margin % is a very important indicator of whether the company is facing problems.

For instance, by 2012, Nokia (NOK)'s problems were well known and its stock had lost more than 90% of its market value since 2007. But Nokia’s Operating Margin % had already been in decline since 2002, although its Earnings per Share (Diluted) were still rising. Investors who paid attention to Operating Margin % would have avoided this huge loss. The same can be said for Research-in-Motion (RIMM).

Therefore, Operating Margin % is a very important screening filter for GuruFocus. GuruFocus's Buffett-Munger screener requires that the profit margin is either consistent or expanding. The Model Portfolio of the Buffett-Munger screener has outperformed the market every year since inception in 2009.


GNI Group Operating Margin % Related Terms


GNI Group Operating Margin % Historical Data

* Premium members only.

The historical data trend for GNI Group's Operating Margin % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

GNI Group Operating Margin % Chart

GNI Group Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Operating Margin %
Get a 7-Day Free Trial Premium Member Only Premium Member Only 12.80 7.91 50.40 5.95 -12.93

GNI Group Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Operating Margin % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -14.52 -5.87 9.61 -39.74 -49.75

TSE:2160 vs VRTX, REGN, ALNY: Operating Margin % Comparison

For the Biotechnology subindustry, GNI Group's Operating Margin %, along with its competitors' market caps and Operating Margin % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


GNI Group Operating Margin % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, GNI Group's Operating Margin % distribution charts can be found below:

* The bar in red indicates where GNI Group's Operating Margin % falls into.


TSE:2160
83GF Score
GNI Group Ltd TSE:2160
Operating Margin % is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

GNI Group Operating Margin % Calculation

Operating Margin % - also known as operating income margin, operating profit margin and return on sales (ROS) - is the ratio of Operating Income divided by net sales or Revenue, usually presented in percent.

GNI Group's Operating Margin % for the fiscal year that ended in Dec. 2025 is calculated as

Operating Margin %=Operating Income (A: Dec. 2025 ) / Revenue (A: Dec. 2025 )
=-3471 / 26840
=-12.93 %

GNI Group's Operating Margin % for the quarter that ended in Mar. 2026 is calculated as

Operating Margin %=Operating Income (Q: Mar. 2026 ) / Revenue (Q: Mar. 2026 )
=-2749 / 5526
=-49.75 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about Operating Margin % →
What does a Operating Margin % of -49.75% mean?
GNI Group (TSE:2160) has a Operating Margin % of -49.75% as of Mar. 2026. Operating margin is the ratio of total operating income to net sales. View historical data on GNI Group and its competitors. According to the industry distribution chart, GNI Group ranks #347 out of 945 companies in the Biotechnology industry, placing it in the top 36.7%.
Is GNI Group's Operating Margin % too high?
GNI Group's current Operating Margin % is -49.75%. Based on the distribution chart, GNI Group ranks #347 out of 945 companies in the Biotechnology industry, which is above the industry midpoint. Overall, GNI Group has a GF Score™ of 83/100 and is considered Modestly Undervalued, reflecting its overall financial health beyond just this single metric.
How does GNI Group's Operating Margin % compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, GNI Group ranks #347 out of 945 companies for Operating Margin %. This puts GNI Group in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Operating Margin % for a Biotechnology company?
A good Operating Margin % depends on the Biotechnology industry context. However, Operating Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Operating Margin % mean?
A high Operating Margin % can signal that a stock is expensive relative to its fundamentals. Operating margin is the ratio of total operating income to net sales. View historical data on GNI Group and its competitors. GNI Group's current Operating Margin % is -49.75%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is GNI Group stock overvalued right now?
Based on GuruFocus' analysis, GNI Group (TSE:2160) is currently considered Modestly Undervalued. The stock's GF Value™ is 円2,777.01, compared to a current price of 円2,507.00 — trading 9.7% below its estimated fair value. The current Operating Margin % is -49.75%. GNI Group's overall GF Score™ is 83/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Operating Margin % calculated?
Operating Margin % is calculated from a company's financial statements. For GNI Group (TSE:2160), the current Operating Margin % is -49.75% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is GNI Group (TSE:2160) Overvalued in 2026?

Based on GuruFocus' analysis, GNI Group stock appears to be undervalued. The current stock price of 円2,507.00 is trading 9.7% below its estimated GF Value™ of 円2,777.01. GuruFocus considers GNI Group to be Modestly Undervalued.

Key valuation signals for TSE:2160:

  • Operating Margin %: -49.75%
  • GF Value™: 円2,777.01 vs. price of 円2,507.00 (9.7% below fair value)
  • GF Score™: 83/100 with 5 warning signs

No single metric tells the full story. See the TSE:2160 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


GNI Group Business Description

Address 2-2-2 Nihonbashi Honcho, 3rd Floor, Nihonbashi Honcho YS Building, Chuo-ku, Tokyo, JPN, 103-0023
GNI Group Ltd is a clinical stage drug development company. It works on the treatment of diseases that are more common in Asia, especially Japan and China. It is engaged in the discovery, development, manufacture, and sale of drugs for the treatment of cancer and inflammatory diseases.
83GF Score

Get the complete analysis for TSE:2160

Operating Margin % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

円2,507.00
Price
円2,777.01
GF Value