VBIO (Valion Bio) Operating Margin %: 0.00% (As of Mar. 2026)

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VBIO Valion Bio Inc VBIO
23 GF Score
Price $0.30
! 1 Warning Sign
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What is Valion Bio Operating Margin %?

Valion Bio VBIO -2.41% 23 Operating Margin % is 0.00% as of Mar. 2026. GuruFocus rates VBIO with a GF Score™ of 23/100. The stock has 1 warning sign investors should review. Among 942 Biotechnology companies, Valion Bio ranks better than 99.79% on this metric.

Operating Margin % is calculated as Operating Income divided by its Revenue. Valion Bio's Operating Income for the three months ended in Mar. 2026 was $-5.63 Mil. Valion Bio's Revenue for the three months ended in Mar. 2026 was $0.00 Mil. Therefore, Valion Bio's Operating Margin % for the quarter that ended in Mar. 2026 was 0.00%.

The historical rank and industry rank for Valion Bio's Operating Margin % or its related term are showing as below:

VBIO' s Operating Margin % Range Over the Past 10 Years
Min: -867.38   Med: -548.8   Max: 17180
Current: 17180


VBIO's Operating Margin % is ranked better than
99.79% of 942 companies
in the Biotechnology industry
Industry Median: -86.855 vs VBIO: 17180.00

Valion Bio's 5-Year Average Operating Margin % Growth Rate was 0.00% per year.

Valion Bio's Operating Income for the three months ended in Mar. 2026 was $-5.63 Mil. Its Operating Income for the trailing twelve months (TTM) ended in Mar. 2026 was $-12.03 Mil.


Valion Bio  (NAS:VBIO) Operating Margin % Explanation

Just like Gross Margin %, it is important to see a company maintains its operating margin over time. Among the same industry, a company with higher operating margin is more efficient in its operation. It is also more stable during industry slowdown or recessions. Peter Lynch prefers those with higher margins than those with lower margins.


Be Aware

Operating Margin % can be manipulated by adjusting the rate of depreciation, depletion and amortization (DDA).

If a company is facing competition, its Operating Margin % may decline. Often the Operating Margin % declines well before the company's Revenue or even profit decline. Therefore, Operating Margin % is a very important indicator of whether the company is facing problems.

For instance, by 2012, Nokia (NOK)'s problems were well known and its stock had lost more than 90% of its market value since 2007. But Nokia’s Operating Margin % had already been in decline since 2002, although its Earnings per Share (Diluted) were still rising. Investors who paid attention to Operating Margin % would have avoided this huge loss. The same can be said for Research-in-Motion (RIMM).

Therefore, Operating Margin % is a very important screening filter for GuruFocus. GuruFocus's Buffett-Munger screener requires that the profit margin is either consistent or expanding. The Model Portfolio of the Buffett-Munger screener has outperformed the market every year since inception in 2009.


Valion Bio Operating Margin % Related Terms


Valion Bio Operating Margin % Historical Data

* Premium members only.

The historical data trend for Valion Bio's Operating Margin % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Valion Bio Operating Margin % Chart

Valion Bio Annual Data
Trend Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Operating Margin %
Get a 7-Day Free Trial -448.13 -548.80 -701.11 0.00 0.00

Valion Bio Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Operating Margin % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 0.00 -2,248.84 -1,700.68 653.97 0.00

VBIO vs ZVSA, LYRA, ATXI: Operating Margin % Comparison

For the Biotechnology subindustry, Valion Bio's Operating Margin %, along with its competitors' market caps and Operating Margin % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Valion Bio Operating Margin % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Valion Bio's Operating Margin % distribution charts can be found below:

* The bar in red indicates where Valion Bio's Operating Margin % falls into.


VBIO
23GF Score
Valion Bio Inc VBIO
Operating Margin % is just one metric. See GF Score™, valuation, warning signs, and more.
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Valion Bio Operating Margin % Calculation

Operating Margin % - also known as operating income margin, operating profit margin and return on sales (ROS) - is the ratio of Operating Income divided by net sales or Revenue, usually presented in percent.

Valion Bio's Operating Margin % for the fiscal year that ended in Dec. 2025 is calculated as

Operating Margin %=Operating Income (A: Dec. 2025 ) / Revenue (A: Dec. 2025 )
=-7.898 / 0
= %

Valion Bio's Operating Margin % for the quarter that ended in Mar. 2026 is calculated as

Operating Margin %=Operating Income (Q: Mar. 2026 ) / Revenue (Q: Mar. 2026 )
=-5.634 / 0
= %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about Operating Margin % →
What does a Operating Margin % of 0.00% mean?
Valion Bio (VBIO) has a Operating Margin % of 0.00% as of Mar. 2026. Operating margin is the ratio of total operating income to net sales. View historical data on Valion Bio and its competitors. According to the industry distribution chart, Valion Bio ranks #2 out of 942 companies in the Biotechnology industry, placing it in the top 0.2%.
Is Valion Bio's Operating Margin % too high?
Valion Bio's current Operating Margin % is 0.00%. Based on the distribution chart, Valion Bio ranks #2 out of 942 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers. Overall, Valion Bio has a GF Score™ of 23/100, reflecting its overall financial health beyond just this single metric.
How does Valion Bio's Operating Margin % compare to ZVSA and LYRA?
According to the Biotechnology industry distribution chart, Valion Bio ranks #2 out of 942 companies for Operating Margin %. This places Valion Bio in the top 0% of its industry — outperforming the majority of peers. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Operating Margin % for a Biotechnology company?
A good Operating Margin % depends on the Biotechnology industry context. However, Operating Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Operating Margin % mean?
A high Operating Margin % can signal that a stock is expensive relative to its fundamentals. Operating margin is the ratio of total operating income to net sales. View historical data on Valion Bio and its competitors. Valion Bio's current Operating Margin % is 0.00%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Valion Bio stock overvalued right now?
Valion Bio (VBIO) has a current Operating Margin % of 0.00%. The current Operating Margin % is 0.00%. Valion Bio's overall GF Score™ is 23/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Operating Margin % calculated?
Operating Margin % is calculated from a company's financial statements. For Valion Bio (VBIO), the current Operating Margin % is 0.00% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Valion Bio Business Description

Address 1305 East Houston Street, Suite 311, Building 1, San Antonio, TX, USA, 78205
Valion Bio Inc is a late-stage biopharmaceutical company developing biologics that activate innate immune pathways for cytoprotection and immune modulation. Its main candidate, Entolimod, is a TLR5 agonist and also advances Entolasta, a next-generation TLR5 agonist, and targets the neutropenia oncology supportive care market.
23GF Score

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Operating Margin % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

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