Santhera Pharmaceuticals Holding AG (XSWX:SANN) Owner Earnings per Share (TTM): -3.78 (As of Dec. 2025)


XSWX:SANN Santhera Pharmaceuticals Holding AG XSWX:SANN
37 GF Score
Price CHF15.10
GF Value CHF23.30
Valuation Possible Value Trap
! 6 Warning Signs
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What is Santhera Pharmaceuticals Holding AG Owner Earnings per Share (TTM)?

Santhera Pharmaceuticals Holding AG XSWX:SANN +1.89% 37 Owner Earnings per Share (TTM) is -3.78 as of Dec. 2025. GuruFocus rates XSWX:SANN with a GF Score™ of 37/100 and a GF Value™ of CHF23.30 (Possible Value Trap). The stock has 6 warning signs investors should review. Among 205 Biotechnology companies, Santhera Pharmaceuticals Holding AG ranks worse than 487804.39% on this metric.

In 1986 Berkshire Hathaway Shareholder Letter, Warren Buffett defined owner earnings as follows:

"These represent (a) reported earnings plus (b) depreciation, depletion, amortization, and certain other non-cash charges...less (c) the average annual amount of capitalized expenditures for plant and equipment, etc. that the business requires to fully maintain its long-term competitive position and its unit volume (If the business requires additional working capital to maintain its competitive position and unit volume, the increment also should be included in (c))...Our owner-earnings equation does not yield the deceptively precise figures provided by GAAP, since (c) must be a guess - and one sometimes very difficult to make. Despite this problem, we consider the owner earnings figure, not the GAAP figure, to be the relevant item for valuation purposes - both for investors in buying stocks and for managers in buying entire businesses...All of this points up the absurdity of the 'cash flow' numbers that are often set forth in Wall Street reports. These numbers routinely include (a) plus (b) - but do not subtract (c)."

Santhera Pharmaceuticals Holding AG's Owner Earnings per Share (TTM) ended in Dec. 2025 was CHF-3.78. It's Price-to-Owner-Earnings ratio for today is 0.


The historical rank and industry rank for Santhera Pharmaceuticals Holding AG's Owner Earnings per Share (TTM) or its related term are showing as below:


During the past 13 years, the highest Price-to-Owner-Earnings ratio of Santhera Pharmaceuticals Holding AG was 70.13. The lowest was 1.84. And the median was 2.20.


XSWX:SANN's Price-to-Owner-Earnings is not ranked *
in the Biotechnology industry.
Industry Median: 24.44
* Ranked among companies with meaningful Price-to-Owner-Earnings only.

Santhera Pharmaceuticals Holding AG's Earnings per Share (Diluted) for the six months ended in Dec. 2025 was CHF-0.74. Its Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Dec. 2025 was CHF-3.78. It's PE Ratio (TTM) ratio for today is At Loss.

Santhera Pharmaceuticals Holding AG's EPS without NRI for the six months ended in Dec. 2025 was CHF-0.68. Its EPS without NRI for the trailing twelve months (TTM) ended in Dec. 2025 was CHF-4.01. It's PE Ratio without NRI ratio for today is At Loss.


Be Aware

Assumption: Companies usually do not report maintenance capital expenditures and growth capital expenditures separately. Here we use estimated numbers and average them over 5 years. The method to estimate maintenance capital expenditures can be found in above part 4.

Note: GuruFocus' Change In Working Capital is provided by Morningstar. It is calculated by adding the items under "Change in operating assets and liabilities" (may refer to a different name for different company) section in Cash Flow Statement from original financial report. And it includes non-current parts of assets and liabilities.


Santhera Pharmaceuticals Holding AG Owner Earnings per Share (TTM) Related Terms


Santhera Pharmaceuticals Holding AG Owner Earnings per Share (TTM) Historical Data

* Premium members only.

The historical data trend for Santhera Pharmaceuticals Holding AG's Owner Earnings per Share (TTM) can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Santhera Pharmaceuticals Holding AG Owner Earnings per Share (TTM) Chart

Santhera Pharmaceuticals Holding AG Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Owner Earnings per Share (TTM)
Get a 7-Day Free Trial Premium Member Only Premium Member Only -11.20 -9.28 4.36 -4.76 -3.78

Santhera Pharmaceuticals Holding AG Semi-Annual Data
Jun16 Dec16 Jun17 Dec17 Jun18 Dec18 Jun19 Dec19 Jun20 Dec20 Jun21 Dec21 Jun22 Dec22 Jun23 Dec23 Jun24 Dec24 Jun25 Dec25
Owner Earnings per Share (TTM) Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 4.36 0.00 -4.76 0.00 -3.78

XSWX:SANN vs VRTX, REGN, ALNY: Owner Earnings per Share (TTM) Comparison

For the Biotechnology subindustry, Santhera Pharmaceuticals Holding AG's Price-to-Owner-Earnings, along with its competitors' market caps and Price-to-Owner-Earnings data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Santhera Pharmaceuticals Holding AG Price-to-Owner-Earnings vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Santhera Pharmaceuticals Holding AG's Price-to-Owner-Earnings distribution charts can be found below:

* The bar in red indicates where Santhera Pharmaceuticals Holding AG's Price-to-Owner-Earnings falls into.


XSWX:SANN
37GF Score
Santhera Pharmaceuticals Holding AG XSWX:SANN
Owner Earnings per Share (TTM) is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Santhera Pharmaceuticals Holding AG Owner Earnings per Share (TTM) Calculation

In 1986 Berkshire Hathaway Shareholder Letter, Warren Buffett defined owner earnings as follows:

"These represent (a) reported earnings plus (b) depreciation, depletion, amortization, and certain other non-cash charges...less (c) the average annual amount of capitalized expenditures for plant and equipment, etc. that the business requires to fully maintain its long-term competitive position and its unit volume. (If the business requires additional working capital to maintain its competitive position and unit volume, the increment also should be included in (c))...Our owner-earnings equation does not yield the deceptively precise figures provided by GAAP, since (c) must be a guess - and one sometimes very difficult to make. Despite this problem, we consider the owner earnings figure, not the GAAP figure, to be the relevant item for valuation purposes - both for investors in buying stocks and for managers in buying entire businesses...All of this points up the absurdity of the 'cash flow' numbers that are often set forth in Wall Street reports. These numbers routinely include (a) plus (b) - but do not subtract (c)."

To make it simple, then you will have:

Owner Earnings per Share (TTM) = (Net Income + Depreciation, Depletion and Amortization + Change In Deferred Tax - 5Y Average of Maintenance Capital Expenditure + Change In Working Capital) / Shares Outstanding (Diluted Average)

Santhera Pharmaceuticals Holding AG's Owner Earnings per Share (TTM) Calculation:

Last Year Average of Last 5 Years
Net Income -49.24
Depreciation, Depletion and Amortization 5.68
Change In Deferred Tax 0.00
5Y Average of Maintenance Capital Expenditure 5.23
Change In Working Capital -0.46
Shares Outstanding (Diluted Average) 13.02

1. Start with "Net Income" from income statement. Santhera Pharmaceuticals Holding AG's Net Income for the trailing twelve months (TTM) ended in Dec. 2025 was CHF-49.24 Mil.

2. "Depreciation, Depletion and Amortization" is from cashflow statement. Santhera Pharmaceuticals Holding AG's Depreciation, Depletion and Amortization for the trailing twelve months (TTM) ended in Dec. 2025 was CHF5.68 Mil. This needs to be added back because company does not actually need to pay cash for it. It is a non-cash item.

3. Other non-cash charges usually include "Stock Based Compensation" and "Change In Deferred Tax":
However, to be conservative, GuruFocus will not add Stock Based Compensation back to net income. Santhera Pharmaceuticals Holding AG's Change In Deferred Tax for the trailing twelve months (TTM) ended in Dec. 2025 was CHF0.00 Mil.

4. Average maintenance capital expenditure over a business/industry cycle: 5-Year Average Maintenance Capital Expenditure = CHF5.23 Mil

It is usually best to take a long-term average of maintenance capital expenditure. Ideally this would be as long as 10 years and include at least one economic downturn. However, since many companies do not have as long as 10-year history, here GuruFocus uses the latest 5 years data to do the calculation. To smooth out unusual years but reflect recent developments, we take an average of the 5 year maintenance capital expenditure.

The following shows how to get maintenance capital expenditure.

First, calculate the revenue change regarding to the previous year. If the revenue decreased from the previous year, then the Maintenance Capital Expenditure = Capital Expenditure (positive).
Second, if the revenue increased from the previous year, then calculate the percentage of Net PPE as of corresponding Revenue.
Growth Capital Expenditure = Percentage of Property, Plant and Equipment as of corresponding Revenue * Revenue Increase
Third, calculate Capital Expenditure (positive) - Growth Capital Expenditure.
If [Capital Expenditure (positive) - Growth Capital Expenditure] was negative, then the Maintenance Capital Expenditure = Capital Expenditure (positive).
If [Capital Expenditure (positive) - Growth Capital Expenditure] was positive, then the Maintenance Capital Expenditure = Capital Expenditure (positive) - Growth Capital Expenditure.
Fourth, get the average of the 5 years maintenance capital expenditure.

Santhera Pharmaceuticals Holding AG's 5-Year Average Maintenance Capital Expenditure = CHF5.23 Mil

5. "Change In Working Capital" is from cashflow statement. Santhera Pharmaceuticals Holding AG's Change In Working Capital for the trailing twelve months (TTM) ended in Dec. 2025 was CHF-0.46 Mil.
Note: GuruFocus' Change in Working Capital is provided by Morningstar. It is calculated by adding the items under "Change in operating assets and liabilities" (may refer to a different name for different company) section in Cash Flow Statement from original financial report. And sometimes it includes non-current parts of assets and liabilities.

6. Santhera Pharmaceuticals Holding AG's Shares Outstanding (Diluted Average) for the months ended in Dec. 2025 was 13.015 Mil.

Santhera Pharmaceuticals Holding AG's Onwer Earnings Per Share for Dec. 2025 is calculated as:

Owner Earnings per Share (TTM)
=( Net Income+Depreciation, Depletion and Amortization+Change In Deferred Tax
=( -49.236 +5.68+0
-5Y Avg of Maintenance CAPEX+Change In Working Capital )/Shares Outstanding (Diluted Average)
-5.2308+-0.458)/13.015
=-3.78

Price-to-Owner-Earnings=Current Price/Owner Earnings per Share (TTM)
=15.10/-3.78
=0

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

What does a Owner Earnings per Share (TTM) of -3.78 mean?
Santhera Pharmaceuticals Holding AG (XSWX:SANN) has a Owner Earnings per Share (TTM) of -3.78 as of Dec. 2025. Warren Buffett defined owner earnings as reported earnings plus depreciation less average maintenance capital expenditure. View historical data on Santhera Pharmaceuticals Holding AG. Over the past decade, Santhera Pharmaceuticals Holding AG's Owner Earnings per Share (TTM) has ranged from 1.84 to 70.13. According to the industry distribution chart, Santhera Pharmaceuticals Holding AG ranks #999999 out of 205 companies in the Biotechnology industry.
Is Santhera Pharmaceuticals Holding AG's Owner Earnings per Share (TTM) too high?
Santhera Pharmaceuticals Holding AG's current Owner Earnings per Share (TTM) is -3.78. Over the past 10 years, this metric has ranged from a low of 1.84 to a high of 70.13. Based on the distribution chart, Santhera Pharmaceuticals Holding AG ranks #999999 out of 205 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Santhera Pharmaceuticals Holding AG has a GF Score™ of 37/100 and is considered Possible Value Trap, reflecting its overall financial health beyond just this single metric.
How does Santhera Pharmaceuticals Holding AG's Owner Earnings per Share (TTM) compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Santhera Pharmaceuticals Holding AG ranks #999999 out of 205 companies for Owner Earnings per Share (TTM). This places Santhera Pharmaceuticals Holding AG in the lower half of its industry. The industry median Owner Earnings per Share (TTM) is 24.44. Historically, Santhera Pharmaceuticals Holding AG's own Owner Earnings per Share (TTM) has ranged from 1.84 to 70.13 over the past decade. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Owner Earnings per Share (TTM) for a Biotechnology company?
The median Owner Earnings per Share (TTM) among Biotechnology companies is 24.44, based on 205 companies in the industry. Companies in the top quartile (top 25%) have a Owner Earnings per Share (TTM) significantly above this median, while those in the bottom quartile fall well below. However, Owner Earnings per Share (TTM) should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Owner Earnings per Share (TTM) mean?
A high Owner Earnings per Share (TTM) can signal that a stock is expensive relative to its fundamentals. Warren Buffett defined owner earnings as reported earnings plus depreciation less average maintenance capital expenditure. View historical data on Santhera Pharmaceuticals Holding AG. For the Biotechnology industry, the median Owner Earnings per Share (TTM) is 24.44 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Santhera Pharmaceuticals Holding AG's current Owner Earnings per Share (TTM) is -3.78. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Santhera Pharmaceuticals Holding AG stock overvalued right now?
Based on GuruFocus' analysis, Santhera Pharmaceuticals Holding AG (XSWX:SANN) is currently considered Possible Value Trap. The stock's GF Value™ is CHF23.30, compared to a current price of CHF15.10 — trading 35.2% below its estimated fair value. The current Owner Earnings per Share (TTM) is -3.78. Santhera Pharmaceuticals Holding AG's overall GF Score™ is 37/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Owner Earnings per Share (TTM) calculated?
Owner Earnings per Share (TTM) is calculated from a company's financial statements. For Santhera Pharmaceuticals Holding AG (XSWX:SANN), the current Owner Earnings per Share (TTM) is -3.78 as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Santhera Pharmaceuticals Holding AG (XSWX:SANN) Overvalued in 2026?

Based on GuruFocus' analysis, Santhera Pharmaceuticals Holding AG stock appears to be undervalued. The current stock price of CHF15.10 is trading 35.2% below its estimated GF Value™ of CHF23.30. GuruFocus considers Santhera Pharmaceuticals Holding AG to be Possible Value Trap.

Key valuation signals for XSWX:SANN:

  • Owner Earnings per Share (TTM): -3.78
  • GF Value™: CHF23.30 vs. price of CHF15.10 (35.2% below fair value)
  • GF Score™: 37/100 with 6 warning signs

No single metric tells the full story. See the XSWX:SANN stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Santhera Pharmaceuticals Holding AG Business Description

Address Hohenrainstrasse 24, Pratteln, CHE, 4133
Santhera Pharmaceuticals Holding AG is a Swiss specialty pharmaceutical company committed to developing and commercializing medicines to meet the needs of patients living with rare and other diseases with high unmet medical needs. It is focused on the development of treatments for pulmonary and neuromuscular diseases that currently lack treatment options. The company is currently engaged in the rollout of its AGAMREE (vamorolone) medicine for the treatment of Duchenne muscular dystrophy (DMD) globally. Santhera has one operating segment, namely the development and commercialization of products for the treatment of neuromuscular diseases. Geographically, the company generates maximum revenue from Europe, and the rest from Asia and North America.
37GF Score

Get the complete analysis for XSWX:SANN

Owner Earnings per Share (TTM) is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

CHF15.10
Price
CHF23.30
GF Value