AC ImmuneACIU +4.70%26 PB Ratio is 6.50 as of Jun. 27, 2026, which is 204% above its 10-year median of 2.14. GuruFocus rates ACIU with a GF Score™ of 26/100 and a GF Value™ of $0.75 (Significantly Overvalued). The stock has 6 warning signs investors should review. Among 1,232 Biotechnology companies, AC Immune ranks worse than 77.19% on this metric.
The PB Ratio, or Price-to-Book ratio, or Price/Book, is a financial ratio used to compare a company's market price to its Book Value per Share. As of today (2026-06-27), AC Immune's share price is $2.56. AC Immune's Book Value per Share for the quarter that ended in Mar. 2026 was $0.39. Hence, AC Immune's PB Ratio of today is 6.50.
The historical rank and industry rank for AC Immune's PB Ratio or its related term are showing as below:
ACIU'
s PB Ratio Range Over the Past 10 Years
Min: 0.75 Med: 2.14 Max: 11.14
Current: 6.56
During the past 12 years, AC Immune's highest PB Ratio was 11.14. The lowest was 0.75. And the median was 2.14.
ACIU's PB Ratio is ranked worse than 77.19% of 1232
companies
in the Biotechnology industry
Industry Median: 2.8
vs ACIU: 6.56
During the past 12 months, AC Immune's average Book Value Per Share Growth Rate was -63.00% per year.
During the past 3 years, the average Book Value Per Share Growth Rate was -36.60% per year.
During the past 5 years, the average Book Value Per Share Growth Rate was -28.60% per year.
During the past 10 years, the average Book Value Per Share Growth Rate was -6.90% per year.
During the past 12 years, the highest 3-Year average Book Value Per Share Growth Rate of AC Immune was 68.20% per year. The lowest was -36.60% per year. And the median was 4.40% per year.
The PB Ratio works the best for the businesses that earn most of their profit from their assets, e.g. banks and insurance companies.
Be Aware
Some businesses have very light assets, such as software companies or insurance agencies. The PB Ratio does not work well for these companies. Some companies even have negative equity, so the PB Ratio cannot be applied to them.
AC Immune PB Ratio Related Terms
AC Immune PB Ratio Historical Data
* Premium members only.
The historical data trend for AC Immune's PB Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
For the Biotechnology subindustry, AC Immune's PB Ratio, along with its competitors' market caps and PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
AC Immune PB Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, AC Immune's PB Ratio distribution charts can be found below:
* The bar in red indicates where AC Immune's PB Ratio falls into.
The PB Ratio, or Price-to-Book ratio, or Price/Book, is a financial ratio used to compare a company's market price to its Book Value per Share. It is a ratio widely used to value stocks.
AC Immune's PB Ratio for today is calculated as follows:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
It can also be calculated from the numbers for the whole company:
A closely related ratio is called Price-to-Tangible-Book. The difference between Price-to-Tangible-Book and PB Ratio is that book value other than intangibles are used in the calculation.
AC Immune (ACIU) has a PB Ratio of 6.50 as of Jun. 27, 2026. Price-to-Book ratio is the ratio of share price to a company's book value per share. View historical data on AC Immune and its competitors. This is 204% above median its historical median of 2.14. Over the past decade, AC Immune's PB Ratio has ranged from 0.75 to 11.14. According to the industry distribution chart, AC Immune ranks #951 out of 1232 companies in the Biotechnology industry, placing it in the top 77.2%.
Is AC Immune's PB Ratio too high?
AC Immune's current PB Ratio of 6.50 is 204% above median its 10-year median of 2.14. Over the past 10 years, this metric has ranged from a low of 0.75 to a high of 11.14. The Biotechnology industry median PB Ratio is 2.80. AC Immune's value of 6.50 is 132.1% above this industry median. Based on the distribution chart, AC Immune ranks #951 out of 1232 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, AC Immune has a GF Score™ of 26/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does AC Immune's PB Ratio compare to TRDA and MGNX?
According to the Biotechnology industry distribution chart, AC Immune ranks #951 out of 1232 companies for PB Ratio. This places AC Immune in the lower half of its industry. The industry median PB Ratio is 2.80. AC Immune's value of 6.50 is 132.1% above this benchmark. Historically, AC Immune's own PB Ratio has ranged from 0.75 to 11.14 over the past decade. While the company's 10-year median is 2.14 vs. the industry median of 2.80, AC Immune has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good PB Ratio for a Biotechnology company?
The median PB Ratio among Biotechnology companies is 2.80, based on 1,232 companies in the industry. Companies in the top quartile (top 25%) have a PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. AC Immune's current PB Ratio of 6.50 is 132.1% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high PB Ratio mean?
A high PB Ratio can signal that a stock is expensive relative to its fundamentals. Price-to-Book ratio is the ratio of share price to a company's book value per share. View historical data on AC Immune and its competitors. For the Biotechnology industry, the median PB Ratio is 2.80 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. AC Immune's current PB Ratio is 6.50, which is 204% above median its own 10-year median of 2.14. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is AC Immune stock overvalued right now?
Based on GuruFocus' analysis, AC Immune (ACIU) is currently considered Significantly Overvalued. The stock's GF Value™ is $0.75, compared to a current price of $2.56 — trading 241.3% above its estimated fair value. The current PB Ratio is 6.50, which is 204% above median its 10-year median of 2.14 and 132.1% above the Biotechnology industry median of 2.80. AC Immune's overall GF Score™ is 26/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is PB Ratio calculated?
PB Ratio is calculated from a company's financial statements. For AC Immune (ACIU), the current PB Ratio is 6.50 as of Jun. 27, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is AC Immune (ACIU) Overvalued in 2026?
Based on GuruFocus' analysis, AC Immune stock appears to be overvalued.
The current stock price of $2.56 is trading 241.3% above its estimated GF Value™ of $0.75.
GuruFocus considers AC Immune to be Significantly Overvalued.
Key valuation signals for ACIU:
PB Ratio: 6.50 (204% above median its 10-year median of 2.14)
GF Value™: $0.75 vs. price of $2.56 (241.3% above fair value)
Industry Position: 132.1% above the Biotechnology median (#951 of 1232)
No single metric tells the full story. See the ACIU stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
AC Immune SA is a clinical stage biopharmaceutical company advancing a portfolio of programs strategically focused on pioneering Precision Medicine for neurodegenerative diseases. The company uses its proprietary technology platforms to discover, design, and develop novel proprietary small molecules, antibodies, and vaccines for the prevention, diagnosis, and treatment of neurodegenerative diseases associated with protein misfolding. The company has one segment. The company currently focuses mostly of its resources on discovering and developing therapeutic and diagnostic products targeting misfolded proteins. The company's pipeline consists of ACI-24.060, Crenezumab, ACI-35.030, Semorinemab, ACI-7104.056, and others.
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