ACIU (AC Immune) Cyclically Adjusted Book per Share: $2.43 (As of Mar. 2026)


ACIU AC Immune SA ACIU
25 GF Score
Price $2.38
GF Value $0.75
Valuation Significantly Overvalued
! 6 Warning Signs
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What is AC Immune Cyclically Adjusted Book per Share?

AC Immune ACIU -10.53% 25 Cyclically Adjusted Book per Share is $2.43 as of Mar. 2026. GuruFocus rates ACIU with a GF Score™ of 25/100 and a GF Value™ of $0.75 (Significantly Overvalued). The stock has 6 warning signs investors should review.

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted Book per Share and the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years.

AC Immune's adjusted book value per share for the three months ended in Mar. 2026 was $0.394. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is $2.43 for the trailing ten years ended in Mar. 2026.

During the past 12 months, AC Immune's average Cyclically Adjusted Book Growth Rate was -5.80% per year. Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the Cyclically Adjusted Book Growth Rate using Cyclically Adjusted Book per Share data.

As of today (2026-07-01), AC Immune's current stock price is $2.38. AC Immune's Cyclically Adjusted Book per Share for the quarter that ended in Mar. 2026 was $2.43. AC Immune's Cyclically Adjusted PB Ratio of today is 0.98.

During the past 12 years, the highest Cyclically Adjusted PB Ratio of AC Immune was 1.60. The lowest was 0.57. And the median was 1.10.


AC Immune  (NAS:ACIU) Cyclically Adjusted Book per Share Explanation

If a company grows much fast than inflation, Cyclically Adjusted Book per Share may underestimate the company's equity. Cyclically Adjusted PB Ratio can seem to be too high even the actual PB Ratio is low.

For the Cyclically Adjusted PB Ratio, the book value of the past 10 years are inflation-adjusted and averaged. The result is used for P/B calculation. Since it looks at the average over the last 10 years, the Cyclically Adjusted PB Ratio is also called CAPB Ratio.

The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.

AC Immune's Cyclically Adjusted PB Ratio of today is calculated as

Cyclically Adjusted PB Ratio=Share Price/Cyclically Adjusted Book per Share
=2.38/2.43
=0.98

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

During the past 12 years, the highest Cyclically Adjusted PB Ratio of AC Immune was 1.60. The lowest was 0.57. And the median was 1.10.


Be Aware

Cyclically Adjusted PB Ratio works better for cyclical companies. It gives you a better idea on the company's real book value.


AC Immune Cyclically Adjusted Book per Share Related Terms


AC Immune Cyclically Adjusted Book per Share Historical Data

* Premium members only.

The historical data trend for AC Immune's Cyclically Adjusted Book per Share can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

AC Immune Cyclically Adjusted Book per Share Chart

AC Immune Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Cyclically Adjusted Book per Share
Get a 7-Day Free Trial Premium Member Only Premium Member Only 0.00 0.00 0.00 2.60 2.46

AC Immune Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Cyclically Adjusted Book per Share Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 2.58 2.54 2.49 2.46 2.43

ACIU vs NAUT, IVVD, OTLK: Cyclically Adjusted Book per Share Comparison

For the Biotechnology subindustry, AC Immune's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


AC Immune Cyclically Adjusted PB Ratio vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, AC Immune's Cyclically Adjusted PB Ratio distribution charts can be found below:

* The bar in red indicates where AC Immune's Cyclically Adjusted PB Ratio falls into.


ACIU
25GF Score
AC Immune SA ACIU
Cyclically Adjusted Book per Share is just one metric. See GF Score™, valuation, warning signs, and more.
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AC Immune Cyclically Adjusted Book per Share Calculation

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted Book per Share and the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years.

What is Cyclically Adjusted Book per Share? How do we calculate Cyclically Adjusted Book per Share?

Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years. Let's use an example to explain.

If we want to calculate the Cyclically Adjusted Book per Share of Wal-Mart (WMT) for Dec. 31, 2010, we need to have the inflation data and the book value per share from 2001 through 2010.

We adjusted the 2001 book value per share data with the total inflation from 2001 through 2010 to the equivalent book value in 2010. If the total inflation from 2001 to 2010 is 40%, and Wal-Mart's book value is $1 a share in 2001, then the 2001's equivalent book value in 2010 is $1.4 a share. If Wal-Mart's book value is $1 again in 2002, and the total inflation from 2002 through 2010 is 35%, then the equivalent 2002 book value in 2010 is $1.35. So on and so forth, you get the equivalent book value per share of past 10 years. Then you add them together and divided the sum by the count to get Cyclically Adjusted Book per Share.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

For example, AC Immune's adjusted Book Value per Share data for the three months ended in Mar. 2026 was:

Adj_Book= Book Value per Share /CPI of Mar. 2026 (Change)*Current CPI (Mar. 2026)
=0.394/107.1957*107.1957
=0.394

Current CPI (Mar. 2026) = 107.1957.

AC Immune Quarterly Data

Book Value per Share CPI Adj_Book
201606 1.686 100.088 1.806
201609 2.712 99.604 2.919
201612 2.460 99.380 2.653
201703 2.334 100.040 2.501
201706 2.194 100.285 2.345
201709 2.041 100.254 2.182
201712 2.064 100.213 2.208
201803 1.946 100.836 2.069
201806 1.462 101.435 1.545
201809 2.943 101.246 3.116
201812 2.650 100.906 2.815
201903 3.578 101.571 3.776
201906 4.106 102.044 4.313
201909 4.119 101.396 4.355
201912 3.858 101.063 4.092
202003 3.853 101.048 4.087
202006 3.676 100.743 3.911
202009 3.554 100.585 3.788
202012 3.372 100.241 3.606
202103 3.070 100.800 3.265
202106 2.870 101.352 3.035
202109 2.673 101.533 2.822
202112 3.017 101.776 3.178
202203 2.760 103.205 2.867
202206 2.506 104.783 2.564
202209 2.335 104.835 2.388
202212 2.169 104.666 2.221
202303 1.976 106.245 1.994
202306 1.852 106.576 1.863
202309 1.654 106.570 1.664
202312 1.873 106.461 1.886
202403 1.646 107.355 1.644
202406 1.385 107.991 1.375
202409 1.553 107.468 1.549
202412 1.254 107.128 1.255
202503 1.066 107.722 1.061
202506 0.914 108.075 0.907
202509 0.780 107.709 0.776
202512 0.554 107.196 0.554
202603 0.394 107.196 0.394

Add all the adjusted book value per share together and divide the count will get our Cyclically Adjusted Book per Share.

What does a Cyclically Adjusted Book per Share of $2.43 mean?
AC Immune (ACIU) has a Cyclically Adjusted Book per Share of $2.43 as of Mar. 2026. Cyclically adjusted book value per share represents the company's inflation-adjusted book value per share over a 10-year period. View historical data on AC Immune and its competitors.
Is AC Immune's Cyclically Adjusted Book per Share too high?
AC Immune's current Cyclically Adjusted Book per Share is $2.43. Overall, AC Immune has a GF Score™ of 25/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does AC Immune's Cyclically Adjusted Book per Share compare to NAUT and IVVD?
AC Immune's Cyclically Adjusted Book per Share of $2.43 can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted Book per Share for a Biotechnology company?
A good Cyclically Adjusted Book per Share depends on the Biotechnology industry context. However, Cyclically Adjusted Book per Share should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted Book per Share mean?
A high Cyclically Adjusted Book per Share can signal that a stock is expensive relative to its fundamentals. Cyclically adjusted book value per share represents the company's inflation-adjusted book value per share over a 10-year period. View historical data on AC Immune and its competitors. AC Immune's current Cyclically Adjusted Book per Share is $2.43. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is AC Immune stock overvalued right now?
Based on GuruFocus' analysis, AC Immune (ACIU) is currently considered Significantly Overvalued. The stock's GF Value™ is $0.75, compared to a current price of $2.38 — trading 217.3% above its estimated fair value. The current Cyclically Adjusted Book per Share is $2.43. AC Immune's overall GF Score™ is 25/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted Book per Share calculated?
Cyclically Adjusted Book per Share is calculated from a company's financial statements. For AC Immune (ACIU), the current Cyclically Adjusted Book per Share is $2.43 as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is AC Immune (ACIU) Overvalued in 2026?

Based on GuruFocus' analysis, AC Immune stock appears to be overvalued. The current stock price of $2.38 is trading 217.3% above its estimated GF Value™ of $0.75. GuruFocus considers AC Immune to be Significantly Overvalued.

Key valuation signals for ACIU:

  • Cyclically Adjusted Book per Share: $2.43
  • GF Value™: $0.75 vs. price of $2.38 (217.3% above fair value)
  • GF Score™: 25/100 with 6 warning signs

No single metric tells the full story. See the ACIU stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


AC Immune Business Description

Other Exchanges IMR:Germany
Address EPFL Innovation Park, Building B, Lausanne, CHE, 1015
AC Immune SA is a clinical stage biopharmaceutical company advancing a portfolio of programs strategically focused on pioneering Precision Medicine for neurodegenerative diseases. The company uses its proprietary technology platforms to discover, design, and develop novel proprietary small molecules, antibodies, and vaccines for the prevention, diagnosis, and treatment of neurodegenerative diseases associated with protein misfolding. The company has one segment. The company currently focuses mostly of its resources on discovering and developing therapeutic and diagnostic products targeting misfolded proteins. The company's pipeline consists of ACI-24.060, Crenezumab, ACI-35.030, Semorinemab, ACI-7104.056, and others.
25GF Score

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Cyclically Adjusted Book per Share is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$2.38
Price
$0.75
GF Value