AC ImmuneACIU -8.08%25 3-Year ROIIC % is -9.01 as of Dec. 2025. GuruFocus rates ACIU with a GF Score™ of 25/100 and a GF Value™ of $0.75 (Significantly Overvalued). The stock has 6 warning signs investors should review. Among 1,321 Biotechnology companies, AC Immune ranks worse than 52.84% on this metric.
3-Year Return on Invested Incremental Capital (3-Year ROIIC %) measures the change in earnings as a percentage of change in investment over 3-year.
AC Immune's 3-Year ROIIC % for the quarter that ended in Dec. 2025 was -9.01%. High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
The industry rank for AC Immune's 3-Year ROIIC % or its related term are showing as below:
ACIU's 3-Year ROIIC % is ranked worse than 52.84% of 1321
companies
in the Biotechnology industry
Industry Median: -4.44
vs ACIU: -9.01
AC Immune (NAS:ACIU) 3-Year ROIIC % Explanation
Return on Incremental Invested Capital (ROIIC) is an extension of Return on Investment Capital (ROIC). ROIC % tells investors how efficiently that profitability is earned per dollar of company capital. ROIIC narrows the focus even further and shows how profitable each additional unit of capital investment could be. ROIIC % is a more powerful metric than ROIC because it measures how much money the company can generate going forward on future capital investments.
High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
Be Aware
It's important to keep in mind that when tracking ROIIC, the metric is better suited to forecasting the trend of future returns rather than measuring current return on investment.
AC Immune 3-Year ROIIC % Related Terms
AC Immune 3-Year ROIIC % Historical Data
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The historical data trend for AC Immune's 3-Year ROIIC % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
ACIU vs NAUT, IVVD, OTLK: 3-Year ROIIC % Comparison
For the Biotechnology subindustry, AC Immune's 3-Year ROIIC %, along with its competitors' market caps and 3-Year ROIIC % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
AC Immune 3-Year ROIIC % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, AC Immune's 3-Year ROIIC % distribution charts can be found below:
* The bar in red indicates where AC Immune's 3-Year ROIIC % falls into.
AC Immune's 3-Year ROIIC % for the quarter that ended in Dec. 2025 is calculated as:
3-Year ROIIC %
=
3-Year Incremental Net Operating Profit After Taxes (NOPAT)**
/
3-Year Incremental Invested Capital**
=
( -86.414 (Dec. 2025) - -76.049 (Dec. 2022) )
/
( 178.3 (Dec. 2025) - 63.309 (Dec. 2022) )
=
-10.365
/
114.991
=
-9.01%***
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
** Annual data of NOPAT and Invested Capital was used to calculate 3-Year ROIIC %.
*** Please be aware that the ROIIC (Return on Invested Capital) calculations are based on company-level data using the primary share class. The calculated data provided is for demonstration purposes and may slightly differ from the results displayed in the title due to potential variations caused by currency exchange rate differences throughout the year.
AC Immune (ACIU) has a 3-Year ROIIC % of -9.01 as of Dec. 2025. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on AC Immune and its competitors. According to the industry distribution chart, AC Immune ranks #698 out of 1321 companies in the Biotechnology industry, placing it in the top 52.8%.
Is AC Immune's 3-Year ROIIC % too high?
AC Immune's current 3-Year ROIIC % is -9.01. Based on the distribution chart, AC Immune ranks #698 out of 1321 companies in the Biotechnology industry, which is below the industry midpoint. Overall, AC Immune has a GF Score™ of 25/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does AC Immune's 3-Year ROIIC % compare to NAUT and IVVD?
According to the Biotechnology industry distribution chart, AC Immune ranks #698 out of 1321 companies for 3-Year ROIIC %. This places AC Immune in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 3-Year ROIIC % for a Biotechnology company?
A good 3-Year ROIIC % depends on the Biotechnology industry context. However, 3-Year ROIIC % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 3-Year ROIIC % mean?
A high 3-Year ROIIC % can signal that a stock is expensive relative to its fundamentals. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on AC Immune and its competitors. AC Immune's current 3-Year ROIIC % is -9.01. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is AC Immune stock overvalued right now?
Based on GuruFocus' analysis, AC Immune (ACIU) is currently considered Significantly Overvalued. The stock's GF Value™ is $0.75, compared to a current price of $2.39 — trading 218.7% above its estimated fair value. The current 3-Year ROIIC % is -9.01. AC Immune's overall GF Score™ is 25/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 3-Year ROIIC % calculated?
3-Year ROIIC % is calculated from a company's financial statements. For AC Immune (ACIU), the current 3-Year ROIIC % is -9.01 as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is AC Immune (ACIU) Overvalued in 2026?
Based on GuruFocus' analysis, AC Immune stock appears to be overvalued.
The current stock price of $2.39 is trading 218.7% above its estimated GF Value™ of $0.75.
GuruFocus considers AC Immune to be Significantly Overvalued.
Key valuation signals for ACIU:
3-Year ROIIC %: -9.01
GF Value™: $0.75 vs. price of $2.39 (218.7% above fair value)
No single metric tells the full story. See the ACIU stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
AC Immune SA is a clinical stage biopharmaceutical company advancing a portfolio of programs strategically focused on pioneering Precision Medicine for neurodegenerative diseases. The company uses its proprietary technology platforms to discover, design, and develop novel proprietary small molecules, antibodies, and vaccines for the prevention, diagnosis, and treatment of neurodegenerative diseases associated with protein misfolding. The company has one segment. The company currently focuses mostly of its resources on discovering and developing therapeutic and diagnostic products targeting misfolded proteins. The company's pipeline consists of ACI-24.060, Crenezumab, ACI-35.030, Semorinemab, ACI-7104.056, and others.
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