X4 PharmaceuticalsXFOR -3.30%29 PB Ratio is 2.21 as of Jun. 25, 2026, which is 94% above its 10-year median of 1.14. GuruFocus rates XFOR with a GF Score™ of 29/100. The stock has 7 warning signs investors should review. Among 1,233 Biotechnology companies, X4 Pharmaceuticals ranks better than 57.99% on this metric.
The historical rank and industry rank for X4 Pharmaceuticals's PB Ratio or its related term are showing as below:
XFOR'
s PB Ratio Range Over the Past 10 Years
Min: 0.13 Med: 1.14 Max: 7.86
Current: 2.21
During the past 11 years, X4 Pharmaceuticals's highest PB Ratio was 7.86. The lowest was 0.13. And the median was 1.14.
XFOR's PB Ratio is ranked better than 57.99% of 1233
companies
in the Biotechnology industry
Industry Median: 2.8
vs XFOR: 2.21
During the past 12 months, X4 Pharmaceuticals's average Book Value Per Share Growth Rate was -54.90% per year.
During the past 3 years, the average Book Value Per Share Growth Rate was -51.80% per year.
During the past 5 years, the average Book Value Per Share Growth Rate was -57.80% per year.
During the past 11 years, the highest 3-Year average Book Value Per Share Growth Rate of X4 Pharmaceuticals was -36.40% per year. The lowest was -61.60% per year. And the median was -54.70% per year.
Back to Basics: PB Ratio
X4 Pharmaceuticals (NAS:XFOR) PB Ratio Explanation
The PB Ratio works the best for the businesses that earn most of their profit from their assets, e.g. banks and insurance companies.
Be Aware
Some businesses have very light assets, such as software companies or insurance agencies. The PB Ratio does not work well for these companies. Some companies even have negative equity, so the PB Ratio cannot be applied to them.
X4 Pharmaceuticals PB Ratio Related Terms
X4 Pharmaceuticals PB Ratio Historical Data
* Premium members only.
The historical data trend for X4 Pharmaceuticals's PB Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
For the Biotechnology subindustry, X4 Pharmaceuticals's PB Ratio, along with its competitors' market caps and PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
X4 Pharmaceuticals PB Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, X4 Pharmaceuticals's PB Ratio distribution charts can be found below:
* The bar in red indicates where X4 Pharmaceuticals's PB Ratio falls into.
The PB Ratio, or Price-to-Book ratio, or Price/Book, is a financial ratio used to compare a company's market price to its Book Value per Share. It is a ratio widely used to value stocks.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
It can also be calculated from the numbers for the whole company:
A closely related ratio is called Price-to-Tangible-Book. The difference between Price-to-Tangible-Book and PB Ratio is that book value other than intangibles are used in the calculation.
X4 Pharmaceuticals (XFOR) has a PB Ratio of 2.21 as of Jun. 25, 2026. Price-to-Book ratio is the ratio of share price to a company's book value per share. View historical data on X4 Pharmaceuticals and its competitors. This is 94% above median its historical median of 1.14. Over the past decade, X4 Pharmaceuticals' PB Ratio has ranged from 0.13 to 7.86. According to the industry distribution chart, X4 Pharmaceuticals ranks #518 out of 1233 companies in the Biotechnology industry, placing it in the top 42%.
Is X4 Pharmaceuticals' PB Ratio too high?
X4 Pharmaceuticals' current PB Ratio of 2.21 is 94% above median its 10-year median of 1.14. Over the past 10 years, this metric has ranged from a low of 0.13 to a high of 7.86. The Biotechnology industry median PB Ratio is 2.80. X4 Pharmaceuticals' value of 2.21 is 21.1% below this industry median. Based on the distribution chart, X4 Pharmaceuticals ranks #518 out of 1233 companies in the Biotechnology industry, which is above the industry midpoint. Overall, X4 Pharmaceuticals has a GF Score™ of 29/100, reflecting its overall financial health beyond just this single metric.
How does X4 Pharmaceuticals' PB Ratio compare to ZURA and LYEL?
According to the Biotechnology industry distribution chart, X4 Pharmaceuticals ranks #518 out of 1233 companies for PB Ratio. This puts X4 Pharmaceuticals in the upper half of its industry. The industry median PB Ratio is 2.80. X4 Pharmaceuticals' value of 2.21 is 21.1% below this benchmark. Historically, X4 Pharmaceuticals' own PB Ratio has ranged from 0.13 to 7.86 over the past decade. While the company's 10-year median is 1.14 vs. the industry median of 2.80, X4 Pharmaceuticals has consistently been below the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good PB Ratio for a Biotechnology company?
The median PB Ratio among Biotechnology companies is 2.80, based on 1,233 companies in the industry. Companies in the top quartile (top 25%) have a PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. X4 Pharmaceuticals's current PB Ratio of 2.21 is 21.1% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high PB Ratio mean?
A high PB Ratio can signal that a stock is expensive relative to its fundamentals. Price-to-Book ratio is the ratio of share price to a company's book value per share. View historical data on X4 Pharmaceuticals and its competitors. For the Biotechnology industry, the median PB Ratio is 2.80 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. X4 Pharmaceuticals's current PB Ratio is 2.21, which is 94% above median its own 10-year median of 1.14. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is X4 Pharmaceuticals stock overvalued right now?
X4 Pharmaceuticals (XFOR) has a current PB Ratio of 2.21. The current PB Ratio is 2.21, which is 94% above median its 10-year median of 1.14 and 21.1% below the Biotechnology industry median of 2.80. X4 Pharmaceuticals' overall GF Score™ is 29/100 with 7 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is PB Ratio calculated?
PB Ratio is calculated from a company's financial statements. For X4 Pharmaceuticals (XFOR), the current PB Ratio is 2.21 as of Jun. 25, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
X4 Pharmaceuticals Inc is a biopharmaceutical company developing and commercializing novel therapeutics for the treatment of rare hematology diseases. The Company's clinical candidate is mavorixafor, a small molecule antagonist of the chemokine receptor CXCR4 that is being developed as an oral, once-daily therapy. It can increase the mobilization of mature, functional white blood cells from the bone marrow into the bloodstream. It also has two pre-clinical candidates X4P-003 and X4P-002 which are CXCR4 antagonists with different properties.
29GF Score
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