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Seaport TherapeuticsSPTX -0.99%11 Return-on-Tangible-Asset is -26.52% as of Dec. 2025. GuruFocus rates SPTX with a GF Score™ of 11/100. The stock has 2 warning signs investors should review. Among 1,415 Biotechnology companies, Seaport Therapeutics ranks better than 57.95% on this metric.
Return-on-Tangible-Asset is calculated as Net Income divided by its average total tangible assets. Total tangible assets equals to Total Assets minus Intangible Assets. Seaport Therapeutics's annualizedNet Income for the quarter that ended in Dec. 2025 was $-74.88 Mil. Seaport Therapeutics's average total tangible assets for the quarter that ended in Dec. 2025 was $282.39 Mil. Therefore, Seaport Therapeutics's annualized Return-on-Tangible-Asset for the quarter that ended in Dec. 2025 was -26.52%.
The historical rank and industry rank for Seaport Therapeutics's Return-on-Tangible-Asset or its related term are showing as below:
SPTX'
s Return-on-Tangible-Asset Range Over the Past 10 Years
Min: -26.52 Med: -20.69 Max: -14.85
Current: -26.52
During the past 2 years, Seaport Therapeutics's highest Return-on-Tangible-Asset was -14.85%. The lowest was -26.52%. And the median was -20.69%.
SPTX's Return-on-Tangible-Asset is ranked better than 57.95% of 1415
companies
in the Biotechnology industry
Industry Median: -36.15
vs SPTX: -26.52
Return-on-Tangible-Asset measures the rate of return on the average total tangible assets (total assets minus intangible assets). Tangible means physical in nature. Intangible Assets are assets that are not physical in nature, and typically "derive their value from legal or intellectual rights." Return-on-Tangible-Asset measures a firm's efficiency at generating profits from its tangible assets. It shows how well a company uses what it has to generate earnings. Return-on-Tangible-Assets can vary drastically across industries. Therefore, Return-on-Tangible-Asset should not be used to compare companies in different industries.
Be Aware
Like ROE and ROA, Return-on-Tangible-Asset is calculated with only 12 months data. Fluctuations in the companys earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective. Return-on-Tangible-Asset can be affected by events such as stock buyback or issuance, and by a companys tax rate and its interest payment. Return-on-Tangible-Asset may not reflect the true earning power of the assets. A more accurate measurement is ROC % (ROC).
Many analysts argue the higher return the better. Buffett states that really high Return-on-Tangible-Asset may indicate vulnerability in the durability of the competitive advantage.
Seaport Therapeutics Return-on-Tangible-Asset Related Terms
Seaport Therapeutics Return-on-Tangible-Asset Historical Data
* Premium members only.
The historical data trend for Seaport Therapeutics's Return-on-Tangible-Asset can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
SPTX vs SVRA, DRTS, FBRX: Return-on-Tangible-Asset Comparison
For the Biotechnology subindustry, Seaport Therapeutics's Return-on-Tangible-Asset, along with its competitors' market caps and Return-on-Tangible-Asset data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Seaport Therapeutics Return-on-Tangible-Asset vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Seaport Therapeutics's Return-on-Tangible-Asset distribution charts can be found below:
* The bar in red indicates where Seaport Therapeutics's Return-on-Tangible-Asset falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
In the calculation of annual Return-on-Tangible-Asset, the net income of the last fiscal year and the average total tangible assets over the fiscal year are used. In calculating the quarterly data,
the Net Income data used here is one times the annual (Dec. 2025) net income data.
What does a Return-on-Tangible-Asset of -26.52% mean?
Seaport Therapeutics (SPTX) has a Return-on-Tangible-Asset of -26.52% as of Dec. 2025. Return on tangible assets is the ratio of current-period net income to average two-period tangible assets. View historical data on Seaport Therapeutics and its competitors. According to the industry distribution chart, Seaport Therapeutics ranks #595 out of 1415 companies in the Biotechnology industry, placing it in the top 42%.
Is Seaport Therapeutics' Return-on-Tangible-Asset too high?
Seaport Therapeutics' current Return-on-Tangible-Asset is -26.52%. Based on the distribution chart, Seaport Therapeutics ranks #595 out of 1415 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Seaport Therapeutics has a GF Score™ of 11/100, reflecting its overall financial health beyond just this single metric.
How does Seaport Therapeutics' Return-on-Tangible-Asset compare to SVRA and DRTS?
According to the Biotechnology industry distribution chart, Seaport Therapeutics ranks #595 out of 1415 companies for Return-on-Tangible-Asset. This puts Seaport Therapeutics in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Return-on-Tangible-Asset for a Biotechnology company?
A good Return-on-Tangible-Asset depends on the Biotechnology industry context. However, Return-on-Tangible-Asset should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Return-on-Tangible-Asset mean?
A high Return-on-Tangible-Asset can signal that a stock is expensive relative to its fundamentals. Return on tangible assets is the ratio of current-period net income to average two-period tangible assets. View historical data on Seaport Therapeutics and its competitors. Seaport Therapeutics's current Return-on-Tangible-Asset is -26.52%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Seaport Therapeutics stock overvalued right now?
Seaport Therapeutics (SPTX) has a current Return-on-Tangible-Asset of -26.52%. The current Return-on-Tangible-Asset is -26.52%. Seaport Therapeutics' overall GF Score™ is 11/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Return-on-Tangible-Asset calculated?
Return-on-Tangible-Asset is calculated from a company's financial statements. For Seaport Therapeutics (SPTX), the current Return-on-Tangible-Asset is -26.52% as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Seaport Therapeutics Inc is a clinical-stage therapeutics company. The company focuses on invention and development of new medicines for patients with depression, anxiety, and other debilitating neuropsychiatric disorders. The company identified clinically validated mechanisms with established efficacy and safety profiles, historically limited by high first-pass metabolism, low bioavailability, and side effects. The company's pipeline products are based on Glyph, company's lymphatic-targeting prodrug technology is designed to bypass first-pass metabolism and thereby enhance a drug's oral bioavailability and reduce side effects.
11GF Score
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