Gyre TherapeuticsGYRE +12.58%43 Return-on-Tangible-Equity is -35.37% as of Mar. 2026. GuruFocus rates GYRE with a GF Score™ of 43/100 and a GF Value™ of $9.81 (Modestly Undervalued). The stock has 2 warning signs investors should review. Among 1,196 Biotechnology companies, Gyre Therapeutics ranks better than 72.24% on this metric.
Return-on-Tangible-Equity is calculated as Net Income divided by its average total shareholder tangible equity. Total shareholder tangible equity equals to Total Stockholders Equity minus Intangible Assets. Gyre Therapeutics's annualized net income for the quarter that ended in Mar. 2026 was $-34.8 Mil. Gyre Therapeutics's average shareholder tangible equity for the quarter that ended in Mar. 2026 was $98.3 Mil. Therefore, Gyre Therapeutics's annualized Return-on-Tangible-Equity for the quarter that ended in Mar. 2026 was -35.37%.
The historical rank and industry rank for Gyre Therapeutics's Return-on-Tangible-Equity or its related term are showing as below:
GYRE'
s Return-on-Tangible-Equity Range Over the Past 10 Years
Min: -803.22 Med: 6.23 Max: 54.82
Current: -7.17
During the past 5 years, Gyre Therapeutics's highest Return-on-Tangible-Equity was 54.82%. The lowest was -803.22%. And the median was 6.23%.
GYRE's Return-on-Tangible-Equity is ranked better than 72.24% of 1196
companies
in the Biotechnology industry
Industry Median: -42.19
vs GYRE: -7.17
Return-on-Tangible-Equity measures the rate of return on the ownership interest (shareholder's tangible equity) of the common stock owners. It measures a firm's efficiency at generating profits from every unit of shareholders' tangible equity (shareholders equity minus intangibles). Return-on-Tangible-Equity shows how well a company uses investment funds to generate earnings growth. Return-on-Tangible-Equitys between 15% and 20% are considered desirable.
Be Aware
Net Income is used.
Because a company can increase its Return-on-Tangible-Equity by having more financial leverage, it is important to watch the leverage ratio when investing in high Return-on-Tangible-Equity companies. Like Return-on-Tangible-Asset, Return-on-Tangible-Equity is calculated with only 12 months data. Fluctuations in company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.
Asset light businesses require very few assets to generate very high earnings. Their Return-on-Tangible-Equitys can be extremely high.
Gyre Therapeutics Return-on-Tangible-Equity Related Terms
Gyre Therapeutics Return-on-Tangible-Equity Historical Data
* Premium members only.
The historical data trend for Gyre Therapeutics's Return-on-Tangible-Equity can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
GYRE vs RLMD, ACRS, SGP: Return-on-Tangible-Equity Comparison
For the Biotechnology subindustry, Gyre Therapeutics's Return-on-Tangible-Equity, along with its competitors' market caps and Return-on-Tangible-Equity data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Gyre Therapeutics Return-on-Tangible-Equity vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Gyre Therapeutics's Return-on-Tangible-Equity distribution charts can be found below:
* The bar in red indicates where Gyre Therapeutics's Return-on-Tangible-Equity falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
In the calculation of annual Return-on-Tangible-Equity, the net income of the last fiscal year and the average total shareholder tangible equity over the fiscal year are used. In calculating the quarterly data,
the net income data used here is four times the quarterly (Mar. 2026) net income data.
Return-on-Tangible-Equity is displayed in the 10-year financial page.
What does a Return-on-Tangible-Equity of -35.37% mean?
Gyre Therapeutics (GYRE) has a Return-on-Tangible-Equity of -35.37% as of Mar. 2026. Return on tangible equity is the ratio of current-period net income to average two-period tangible equity. View historical data on Gyre Therapeutics and its competitors. According to the industry distribution chart, Gyre Therapeutics ranks #332 out of 1196 companies in the Biotechnology industry, placing it in the top 27.8%.
Is Gyre Therapeutics' Return-on-Tangible-Equity too high?
Gyre Therapeutics' current Return-on-Tangible-Equity is -35.37%. Based on the distribution chart, Gyre Therapeutics ranks #332 out of 1196 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Gyre Therapeutics has a GF Score™ of 43/100 and is considered Modestly Undervalued, reflecting its overall financial health beyond just this single metric.
How does Gyre Therapeutics' Return-on-Tangible-Equity compare to RLMD and ACRS?
According to the Biotechnology industry distribution chart, Gyre Therapeutics ranks #332 out of 1196 companies for Return-on-Tangible-Equity. This puts Gyre Therapeutics in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Return-on-Tangible-Equity for a Biotechnology company?
A good Return-on-Tangible-Equity depends on the Biotechnology industry context. However, Return-on-Tangible-Equity should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Return-on-Tangible-Equity mean?
A high Return-on-Tangible-Equity can signal that a stock is expensive relative to its fundamentals. Return on tangible equity is the ratio of current-period net income to average two-period tangible equity. View historical data on Gyre Therapeutics and its competitors. Gyre Therapeutics's current Return-on-Tangible-Equity is -35.37%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Gyre Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Gyre Therapeutics (GYRE) is currently considered Modestly Undervalued. The stock's GF Value™ is $9.81, compared to a current price of $7.36 — trading 25% below its estimated fair value. The current Return-on-Tangible-Equity is -35.37%. Gyre Therapeutics' overall GF Score™ is 43/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Return-on-Tangible-Equity calculated?
Return-on-Tangible-Equity is calculated from a company's financial statements. For Gyre Therapeutics (GYRE), the current Return-on-Tangible-Equity is -35.37% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Gyre Therapeutics (GYRE) Overvalued in 2026?
Based on GuruFocus' analysis, Gyre Therapeutics stock appears to be undervalued.
The current stock price of $7.36 is trading 25% below its estimated GF Value™ of $9.81.
GuruFocus considers Gyre Therapeutics to be Modestly Undervalued.
Key valuation signals for GYRE:
Return-on-Tangible-Equity: -35.37%
GF Value™: $9.81 vs. price of $7.36 (25% below fair value)
No single metric tells the full story. See the GYRE stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Gyre Therapeutics Inc is a commercial-stage biopharmaceutical company focused on the development and commercialization of small-molecule therapies for the treatment of organ fibrosis and inflammatory diseases. The company's commercial-stage products include ETUARY, Avatrombopag, and Nintedanib. In addition, it is focused on the development and commercialization of Hydronidone (F351) for the treatment of Metabolic Dysfunction Associated Steatohepatitis (MASH-associated liver fibrosis (MASH fibrosis). Gyre is also advancing a diverse pipeline of different drug candidates in China, including F573, F528, and F230. The company's reportable segments are Gyre Pharmaceuticals, which derives maximum revenue from the sale of ETUARY and certain generic drugs in the PRC, Gyre, and Other.
43GF Score
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