SER (Serina Therapeutics) Return-on-Tangible-Equity: -313.71% (As of Mar. 2026)


SER Serina Therapeutics Inc SER
12 GF Score
Price $1.97
! 1 Warning Sign
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What is Serina Therapeutics Return-on-Tangible-Equity?

Serina Therapeutics SER +8.84% 12 Return-on-Tangible-Equity is -313.71% as of Mar. 2026. GuruFocus rates SER with a GF Score™ of 12/100. The stock has 1 warning sign investors should review. Among 1,201 Biotechnology companies, Serina Therapeutics ranks worse than 94.59% on this metric.

Return-on-Tangible-Equity is calculated as Net Income divided by its average total shareholder tangible equity. Total shareholder tangible equity equals to Total Stockholders Equity minus Intangible Assets. Serina Therapeutics's annualized net income for the quarter that ended in Mar. 2026 was $-27.59 Mil. Serina Therapeutics's average shareholder tangible equity for the quarter that ended in Mar. 2026 was $8.80 Mil. Therefore, Serina Therapeutics's annualized Return-on-Tangible-Equity for the quarter that ended in Mar. 2026 was -313.71%.

The historical rank and industry rank for Serina Therapeutics's Return-on-Tangible-Equity or its related term are showing as below:

SER' s Return-on-Tangible-Equity Range Over the Past 10 Years
Min: -6351.66   Med: -6351.66   Max: -465.28
Current: -465.28

During the past 5 years, Serina Therapeutics's highest Return-on-Tangible-Equity was -465.28%. The lowest was -6,351.66%. And the median was -6,351.66%.

SER's Return-on-Tangible-Equity is ranked worse than
94.59% of 1201 companies
in the Biotechnology industry
Industry Median: -42.4 vs SER: -465.28

Serina Therapeutics  (AMEX:SER) Return-on-Tangible-Equity Explanation

Return-on-Tangible-Equity measures the rate of return on the ownership interest (shareholder's tangible equity) of the common stock owners. It measures a firm's efficiency at generating profits from every unit of shareholders' tangible equity (shareholders equity minus intangibles). Return-on-Tangible-Equity shows how well a company uses investment funds to generate earnings growth. Return-on-Tangible-Equitys between 15% and 20% are considered desirable.


Be Aware

Net Income is used.

Because a company can increase its Return-on-Tangible-Equity by having more financial leverage, it is important to watch the leverage ratio when investing in high Return-on-Tangible-Equity companies. Like Return-on-Tangible-Asset, Return-on-Tangible-Equity is calculated with only 12 months data. Fluctuations in company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.

Asset light businesses require very few assets to generate very high earnings. Their Return-on-Tangible-Equitys can be extremely high.


Serina Therapeutics Return-on-Tangible-Equity Related Terms


Serina Therapeutics Return-on-Tangible-Equity Historical Data

* Premium members only.

The historical data trend for Serina Therapeutics's Return-on-Tangible-Equity can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Serina Therapeutics Return-on-Tangible-Equity Chart

Serina Therapeutics Annual Data
Trend Dec21 Dec22 Dec23 Dec24 Dec25
Return-on-Tangible-Equity
0.00 0.00 Negative Tangible Equity 0.00 -6,351.66

Serina Therapeutics Quarterly Data
Dec21 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Return-on-Tangible-Equity Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -1,644.06 -1,472.57 -1,029.76 -1,548.93 -313.71

SER vs NRSN, IGC, PVCT: Return-on-Tangible-Equity Comparison

For the Biotechnology subindustry, Serina Therapeutics's Return-on-Tangible-Equity, along with its competitors' market caps and Return-on-Tangible-Equity data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Serina Therapeutics Return-on-Tangible-Equity vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Serina Therapeutics's Return-on-Tangible-Equity distribution charts can be found below:

* The bar in red indicates where Serina Therapeutics's Return-on-Tangible-Equity falls into.


SER
12GF Score
Serina Therapeutics Inc SER
Return-on-Tangible-Equity is just one metric. See GF Score™, valuation, warning signs, and more.
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Serina Therapeutics Return-on-Tangible-Equity Calculation

Serina Therapeutics's annualized Return-on-Tangible-Equity for the fiscal year that ended in Dec. 2025 is calculated as

Return-on-Tangible-Equity=Net Income/( (Total Tangible Equity+Total Tangible Equity)/ count )
(A: Dec. 2025 )  (A: Dec. 2024 )(A: Dec. 2025 )
=Net Income/( (Total Stockholders Equity - Intangible Assets+Total Stockholders Equity - Intangible Assets )/ count )
(A: Dec. 2025 )  (A: Dec. 2024 )(A: Dec. 2025 )
=-19.182/( (0.641+-0.037 )/ 2 )
=-19.182/0.302
=-6,351.66 %

Serina Therapeutics's annualized Return-on-Tangible-Equity for the quarter that ended in Mar. 2026 is calculated as

Return-on-Tangible-Equity=Net Income/( (Total Tangible Equity+Total Tangible Equity)/ count )
(Q: Mar. 2026 )  (Q: Dec. 2025 )(Q: Mar. 2026 )
=Net Income/( (Total Stockholders Equity - Intangible Assets+Total Stockholders Equity - Intangible Assets)/ count )
(Q: Mar. 2026 )  (Q: Dec. 2025 )(Q: Mar. 2026 )
=-27.592/( (-0.037+17.628)/ 2 )
=-27.592/8.7955
=-313.71 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

In the calculation of annual Return-on-Tangible-Equity, the net income of the last fiscal year and the average total shareholder tangible equity over the fiscal year are used. In calculating the quarterly data, the net income data used here is four times the quarterly (Mar. 2026) net income data. Return-on-Tangible-Equity is displayed in the 10-year financial page.

What does a Return-on-Tangible-Equity of -313.71% mean?
Serina Therapeutics (SER) has a Return-on-Tangible-Equity of -313.71% as of Mar. 2026. Return on tangible equity is the ratio of current-period net income to average two-period tangible equity. View historical data on Serina Therapeutics and its competitors. According to the industry distribution chart, Serina Therapeutics ranks #1136 out of 1201 companies in the Biotechnology industry, placing it in the top 94.6%.
Is Serina Therapeutics' Return-on-Tangible-Equity too high?
Serina Therapeutics' current Return-on-Tangible-Equity is -313.71%. Based on the distribution chart, Serina Therapeutics ranks #1136 out of 1201 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Serina Therapeutics has a GF Score™ of 12/100, reflecting its overall financial health beyond just this single metric.
How does Serina Therapeutics' Return-on-Tangible-Equity compare to NRSN and IGC?
According to the Biotechnology industry distribution chart, Serina Therapeutics ranks #1136 out of 1201 companies for Return-on-Tangible-Equity. This places Serina Therapeutics in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Return-on-Tangible-Equity for a Biotechnology company?
A good Return-on-Tangible-Equity depends on the Biotechnology industry context. However, Return-on-Tangible-Equity should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Return-on-Tangible-Equity mean?
A high Return-on-Tangible-Equity can signal that a stock is expensive relative to its fundamentals. Return on tangible equity is the ratio of current-period net income to average two-period tangible equity. View historical data on Serina Therapeutics and its competitors. Serina Therapeutics's current Return-on-Tangible-Equity is -313.71%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Serina Therapeutics stock overvalued right now?
Serina Therapeutics (SER) has a current Return-on-Tangible-Equity of -313.71%. The current Return-on-Tangible-Equity is -313.71%. Serina Therapeutics' overall GF Score™ is 12/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Return-on-Tangible-Equity calculated?
Return-on-Tangible-Equity is calculated from a company's financial statements. For Serina Therapeutics (SER), the current Return-on-Tangible-Equity is -313.71% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Serina Therapeutics Business Description

Other Exchanges 2BO:Germany
Address 601 Genome Way, Suite 2001, Huntsville, AL, USA, 35806
Serina Therapeutics Inc is a clinical-stage biotechnology company developing a pipeline of wholly-owned drug product candidates to treat neurological diseases and pain. Serina's POZ Platform delivery technology is engineered to provide control in drug loading and more precision in the rate of release of attached drugs, enabling the potential of certain challenging small molecules, while addressing the limitations of polyethylene glycol (PEG) and other biocompatible polymers. The company has one reportable segment relating to the research and development of its POZ platform. The segment derives its revenues from Grant revenue. Its main product candidate, SER-252 for advanced Parkinson's disease, is anticipated to enter clinical trials.
12GF Score

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