CVKD (Cadrenal Therapeutics) ROE % Adjusted to Book Value: -61.68% (As of Mar. 2026)

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CVKD Cadrenal Therapeutics Inc CVKD
30 GF Score
Price $2.03
! 2 Warning Signs
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What is Cadrenal Therapeutics ROE % Adjusted to Book Value?

Cadrenal Therapeutics CVKD 30 ROE % Adjusted to Book Value is -61.68% as of Mar. 2026. GuruFocus rates CVKD with a GF Score™ of 30/100. The stock has 2 warning signs investors should review.

Cadrenal Therapeutics's ROE % for the quarter that ended in Mar. 2026 was -440.39%. Cadrenal Therapeutics's PB Ratio for the quarter that ended in Mar. 2026 was 7.14. Cadrenal Therapeutics's ROE % Adjusted to Book Value for the quarter that ended in Mar. 2026 was -61.68%.


Cadrenal Therapeutics ROE % Adjusted to Book Value Related Terms


Cadrenal Therapeutics ROE % Adjusted to Book Value Historical Data

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The historical data trend for Cadrenal Therapeutics's ROE % Adjusted to Book Value can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Cadrenal Therapeutics ROE % Adjusted to Book Value Chart

Cadrenal Therapeutics Annual Data
Trend Dec22 Dec23 Dec24 Dec25
ROE % Adjusted to Book Value
0.00 -624.53 -40.57 -45.00

Cadrenal Therapeutics Quarterly Data
Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
ROE % Adjusted to Book Value Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -41.19 -50.04 -29.35 -76.84 -61.68

CVKD vs RVPH, IMNN, ACXP: ROE % Adjusted to Book Value Comparison

For the Biotechnology subindustry, Cadrenal Therapeutics's ROE % Adjusted to Book Value, along with its competitors' market caps and ROE % Adjusted to Book Value data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Cadrenal Therapeutics ROE % Adjusted to Book Value vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Cadrenal Therapeutics's ROE % Adjusted to Book Value distribution charts can be found below:

* The bar in red indicates where Cadrenal Therapeutics's ROE % Adjusted to Book Value falls into.


CVKD
30GF Score
Cadrenal Therapeutics Inc CVKD
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Cadrenal Therapeutics ROE % Adjusted to Book Value Calculation

Cadrenal Therapeutics's ROE % Adjusted to Book Value for the fiscal year that ended in Dec. 2025 is calculated as

ROE % Adjusted to Book Value=ROE % / PB Ratio
=-260.08% / 5.78
=-45.00%

Cadrenal Therapeutics's ROE % Adjusted to Book Value for the quarter that ended in Mar. 2026 is calculated as

ROE % Adjusted to Book Value=ROE % / PB Ratio
=-440.39% / 7.14
=-61.68%

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

What does a ROE % Adjusted to Book Value of -61.68% mean?
Cadrenal Therapeutics (CVKD) has a ROE % Adjusted to Book Value of -61.68% as of Mar. 2026. Return on equity adjusted to book is the ratio of return on equity to price-book ratio. View historical data on Cadrenal Therapeutics and its competitors.
Is Cadrenal Therapeutics' ROE % Adjusted to Book Value too high?
Cadrenal Therapeutics' current ROE % Adjusted to Book Value is -61.68%. Overall, Cadrenal Therapeutics has a GF Score™ of 30/100, reflecting its overall financial health beyond just this single metric.
How does Cadrenal Therapeutics' ROE % Adjusted to Book Value compare to RVPH and IMNN?
Cadrenal Therapeutics' ROE % Adjusted to Book Value of -61.68% can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROE % Adjusted to Book Value for a Biotechnology company?
A good ROE % Adjusted to Book Value depends on the Biotechnology industry context. However, ROE % Adjusted to Book Value should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROE % Adjusted to Book Value mean?
A high ROE % Adjusted to Book Value can signal that a stock is expensive relative to its fundamentals. Return on equity adjusted to book is the ratio of return on equity to price-book ratio. View historical data on Cadrenal Therapeutics and its competitors. Cadrenal Therapeutics's current ROE % Adjusted to Book Value is -61.68%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Cadrenal Therapeutics stock overvalued right now?
Cadrenal Therapeutics (CVKD) has a current ROE % Adjusted to Book Value of -61.68%. The current ROE % Adjusted to Book Value is -61.68%. Cadrenal Therapeutics' overall GF Score™ is 30/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROE % Adjusted to Book Value calculated?
ROE % Adjusted to Book Value is calculated from a company's financial statements. For Cadrenal Therapeutics (CVKD), the current ROE % Adjusted to Book Value is -61.68% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Cadrenal Therapeutics Business Description

Address 822 A1A North, Suite 306, Ponte Vedra, FL, USA, 32082
Cadrenal Therapeutics Inc is a late-stage biopharmaceutical company advancing novel therapies for life-threatening immune and thrombotic conditions. Its product candidate, CAD-1005, is a first-in-class selective 12-LOX inhibitor being developed to treat heparin-induced thrombocytopenia (HIT), a deadly immune-mediated thrombotic disorder. The pipeline includes two additional clinical-stage assets: tecarfarin and frunexian. Tecarfarin is an oral vitamin K antagonist (VKA) designed to prevent heart attacks, strokes, and deaths due to blood clots in patients requiring chronic anticoagulation. Frunexian is a first-in-class, Phase 2-ready intravenous Factor XIa inhibitor designed for acute care settings where contact activation of coagulation by medical devices or artificial surfaces.
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