GUTS (Fractyl Health) ROE % Adjusted to Book Value: 70.55% (As of Mar. 2026)

Author: Vera Yuan Vera Yuan
Vera Yuan
Vera Yuan
Director of Data and Quant Analytics at GuruFocus
Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Reviewed by: Charlie Tian Charlie Tian
Charlie Tian
Charlie Tian
Founder & CEO of GuruFocus
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.

GUTS Fractyl Health Inc GUTS
11 GF Score
Price $0.70
! 2 Warning Signs
View Full Analysis

What is Fractyl Health ROE % Adjusted to Book Value?

Fractyl Health GUTS +1.15% 11 ROE % Adjusted to Book Value is 70.55% as of Mar. 2026. GuruFocus rates GUTS with a GF Score™ of 11/100. The stock has 2 warning signs investors should review.

Fractyl Health's ROE % for the quarter that ended in Mar. 2026 was 239.16%. Fractyl Health's PB Ratio for the quarter that ended in Mar. 2026 was 3.39. Fractyl Health's ROE % Adjusted to Book Value for the quarter that ended in Mar. 2026 was 70.55%.

Fractyl Health ROE % Adjusted to Book Value Related Terms

Fractyl Health ROE % Adjusted to Book Value Historical Data

* Premium members only.

The historical data trend for Fractyl Health's ROE % Adjusted to Book Value can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Fractyl Health ROE % Adjusted to Book Value Chart

Fractyl Health Annual Data
Trend Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
ROE % Adjusted to Book Value
Get a 7-Day Free Trial 0.00 0.00 0.00 0.00 -20.97

Fractyl Health Quarterly Data
Sep20 Dec20 Jun21 Sep21 Dec21 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
ROE % Adjusted to Book Value Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -59.63 0.00 0.00 -157.00 70.55

GUTS vs ENGN, ANIX, VTVT: ROE % Adjusted to Book Value Comparison

For the Biotechnology subindustry, Fractyl Health's ROE % Adjusted to Book Value, along with its competitors' market caps and ROE % Adjusted to Book Value data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.

Fractyl Health ROE % Adjusted to Book Value vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Fractyl Health's ROE % Adjusted to Book Value distribution charts can be found below:

* The bar in red indicates where Fractyl Health's ROE % Adjusted to Book Value falls into.


GUTS
11GF Score
Fractyl Health Inc GUTS
ROE % Adjusted to Book Value is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Fractyl Health ROE % Adjusted to Book Value Calculation

Fractyl Health's ROE % Adjusted to Book Value for the fiscal year that ended in Dec. 2025 is calculated as

ROE % Adjusted to Book Value=ROE % / PB Ratio
=-744.17% / 35.48
=-20.97%

Fractyl Health's ROE % Adjusted to Book Value for the quarter that ended in Mar. 2026 is calculated as

ROE % Adjusted to Book Value=ROE % / PB Ratio
=239.16% / 3.39
=70.55%

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

What does a ROE % Adjusted to Book Value of 70.55% mean?
Fractyl Health (GUTS) has a ROE % Adjusted to Book Value of 70.55% as of Mar. 2026. Return on equity adjusted to book is the ratio of return on equity to price-book ratio. View historical data on Fractyl Health and its competitors.
Is Fractyl Health's ROE % Adjusted to Book Value too high?
Fractyl Health's current ROE % Adjusted to Book Value is 70.55%. Overall, Fractyl Health has a GF Score™ of 11/100, reflecting its overall financial health beyond just this single metric.
How does Fractyl Health's ROE % Adjusted to Book Value compare to ENGN and ANIX?
Fractyl Health's ROE % Adjusted to Book Value of 70.55% can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROE % Adjusted to Book Value for a Biotechnology company?
A good ROE % Adjusted to Book Value depends on the Biotechnology industry context. However, ROE % Adjusted to Book Value should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROE % Adjusted to Book Value mean?
A high ROE % Adjusted to Book Value can signal that a stock is expensive relative to its fundamentals. Return on equity adjusted to book is the ratio of return on equity to price-book ratio. View historical data on Fractyl Health and its competitors. Fractyl Health's current ROE % Adjusted to Book Value is 70.55%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Fractyl Health stock overvalued right now?
Fractyl Health (GUTS) has a current ROE % Adjusted to Book Value of 70.55%. The current ROE % Adjusted to Book Value is 70.55%. Fractyl Health's overall GF Score™ is 11/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROE % Adjusted to Book Value calculated?
ROE % Adjusted to Book Value is calculated from a company's financial statements. For Fractyl Health (GUTS), the current ROE % Adjusted to Book Value is 70.55% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Fractyl Health Business Description

Address 3 Van de Graaff Drive, Suite 200, Burlington, MA, USA, 01803
Fractyl Health Inc is a clinical stage metabolic therapeutics company focused on pioneering novel approaches to treat obesity and type 2 diabetes (T2D). Its Revita and Rejuva candidates are designed to target root causes of metabolic diseases, allowing the company to advance metabolic disease treatment from chronic management towards prevention and reversion of the disease. The Revita DMR System (Revita), its lead product candidate, is based on its insights surrounding the potential role of the gut in obesity.
11GF Score

Get the complete analysis for GUTS

ROE % Adjusted to Book Value is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$0.70
Price