PHIO (Phio Pharmaceuticals) ROE % Adjusted to Book Value: -101.72% (As of Mar. 2026)


PHIO Phio Pharmaceuticals Corp PHIO
28 GF Score
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What is Phio Pharmaceuticals ROE % Adjusted to Book Value?

Phio Pharmaceuticals PHIO -0.97% 28 ROE % Adjusted to Book Value is -101.72% as of Mar. 2026. GuruFocus rates PHIO with a GF Score™ of 28/100. The stock has 1 warning sign investors should review.

Phio Pharmaceuticals's ROE % for the quarter that ended in Mar. 2026 was -87.48%. Phio Pharmaceuticals's PB Ratio for the quarter that ended in Mar. 2026 was 0.86. Phio Pharmaceuticals's ROE % Adjusted to Book Value for the quarter that ended in Mar. 2026 was -101.72%.

Phio Pharmaceuticals ROE % Adjusted to Book Value Related Terms

Phio Pharmaceuticals ROE % Adjusted to Book Value Historical Data

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The historical data trend for Phio Pharmaceuticals's ROE % Adjusted to Book Value can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Phio Pharmaceuticals ROE % Adjusted to Book Value Chart

Phio Pharmaceuticals Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
ROE % Adjusted to Book Value
Get a 7-Day Free Trial Premium Member Only Premium Member Only -122.65 -149.06 -315.16 -173.98 -114.67

Phio Pharmaceuticals Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
ROE % Adjusted to Book Value Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -164.25 -69.49 -65.75 -103.70 -101.72

PHIO vs PBM, KPRX, OSRH: ROE % Adjusted to Book Value Comparison

For the Biotechnology subindustry, Phio Pharmaceuticals's ROE % Adjusted to Book Value, along with its competitors' market caps and ROE % Adjusted to Book Value data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.

Phio Pharmaceuticals ROE % Adjusted to Book Value vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Phio Pharmaceuticals's ROE % Adjusted to Book Value distribution charts can be found below:

* The bar in red indicates where Phio Pharmaceuticals's ROE % Adjusted to Book Value falls into.


PHIO
28GF Score
Phio Pharmaceuticals Corp PHIO
ROE % Adjusted to Book Value is just one metric. See GF Score™, valuation, warning signs, and more.
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Phio Pharmaceuticals ROE % Adjusted to Book Value Calculation

Phio Pharmaceuticals's ROE % Adjusted to Book Value for the fiscal year that ended in Dec. 2025 is calculated as

ROE % Adjusted to Book Value=ROE % / PB Ratio
=-69.95% / 0.61
=-114.67%

Phio Pharmaceuticals's ROE % Adjusted to Book Value for the quarter that ended in Mar. 2026 is calculated as

ROE % Adjusted to Book Value=ROE % / PB Ratio
=-87.48% / 0.86
=-101.72%

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

What does a ROE % Adjusted to Book Value of -101.72% mean?
Phio Pharmaceuticals (PHIO) has a ROE % Adjusted to Book Value of -101.72% as of Mar. 2026. Return on equity adjusted to book is the ratio of return on equity to price-book ratio. View historical data on Phio Pharmaceuticals and its competitors.
Is Phio Pharmaceuticals' ROE % Adjusted to Book Value too high?
Phio Pharmaceuticals' current ROE % Adjusted to Book Value is -101.72%. Overall, Phio Pharmaceuticals has a GF Score™ of 28/100, reflecting its overall financial health beyond just this single metric.
How does Phio Pharmaceuticals' ROE % Adjusted to Book Value compare to PBM and KPRX?
Phio Pharmaceuticals' ROE % Adjusted to Book Value of -101.72% can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROE % Adjusted to Book Value for a Biotechnology company?
A good ROE % Adjusted to Book Value depends on the Biotechnology industry context. However, ROE % Adjusted to Book Value should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROE % Adjusted to Book Value mean?
A high ROE % Adjusted to Book Value can signal that a stock is expensive relative to its fundamentals. Return on equity adjusted to book is the ratio of return on equity to price-book ratio. View historical data on Phio Pharmaceuticals and its competitors. Phio Pharmaceuticals's current ROE % Adjusted to Book Value is -101.72%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Phio Pharmaceuticals stock overvalued right now?
Phio Pharmaceuticals (PHIO) has a current ROE % Adjusted to Book Value of -101.72%. The current ROE % Adjusted to Book Value is -101.72%. Phio Pharmaceuticals' overall GF Score™ is 28/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROE % Adjusted to Book Value calculated?
ROE % Adjusted to Book Value is calculated from a company's financial statements. For Phio Pharmaceuticals (PHIO), the current ROE % Adjusted to Book Value is -101.72% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Phio Pharmaceuticals Business Description

Address 411 Swedeland Road, Suite 23-1080, King of Prussia, PA, USA, 19406
Phio Pharmaceuticals Corp is a clinical-stage biopharmaceutical company whose proprietary INTASYL small-interfering RNA gene silencing technology is designed to make immune cells more effective in killing tumor cells. Its pipeline programs are PH-762 and PH-894. The group is developing therapeutics that are designed to leverage INTASYL to precisely target specific proteins that reduce the body's ability to fight cancer, without the need for specialized formulations or drug delivery systems. It is committed to discovering and developing cancer treatments for patients by creating new pathways toward a cancer-free future. The Company operates with a single operating segment, the Clinical segment, and all assets are located in the United States.
28GF Score

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ROE % Adjusted to Book Value is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

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