Oculis Holding AG (OISE:OCS) 1-Year ROIIC % : -3,592.29% (As of Mar. 2026)

Author: Vera Yuan Vera Yuan
Vera Yuan
Vera Yuan
Director of Data and Quant Analytics at GuruFocus
Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Reviewed by: Charlie Tian Charlie Tian
Charlie Tian
Charlie Tian
Founder & CEO of GuruFocus
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.

OISE:OCS Oculis Holding AG OISE:OCS
26 GF Score
Price kr1,350.00
! 1 Warning Sign
View Full Analysis

What is Oculis Holding AG 1-Year ROIIC %?

Oculis Holding AG OISE:OCS -1.10% 26 1-Year ROIIC % is -3,592.29 as of Mar. 2026. GuruFocus rates OISE:OCS with a GF Score™ of 26/100. The stock has 1 warning sign investors should review. Among 1,336 Biotechnology companies, Oculis Holding AG ranks worse than 97.08% on this metric.

1-Year Return on Invested Incremental Capital (1-Year ROIIC %) measures the change in earnings as a percentage of change in investment over 1-year. Oculis Holding AG's 1-Year ROIIC % for the quarter that ended in Mar. 2026 was -3,592.29%. High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.

The industry rank for Oculis Holding AG's 1-Year ROIIC % or its related term are showing as below:

OISE:OCS's 1-Year ROIIC % is ranked worse than
97.08% of 1336 companies
in the Biotechnology industry
Industry Median: -8.825 vs OISE:OCS: -3592.29

Oculis Holding AG  (OISE:OCS) 1-Year ROIIC % Explanation

Return on Incremental Invested Capital (ROIIC) is an extension of Return on Investment Capital (ROIC). ROIC % tells investors how efficiently that profitability is earned per dollar of company capital. ROIIC narrows the focus even further and shows how profitable each additional unit of capital investment could be. ROIIC % is a more powerful metric than ROIC because it measures how much money the company can generate going forward on future capital investments.

High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.

Be Aware

It's important to keep in mind that when tracking ROIIC, the metric is better suited to forecasting the trend of future returns rather than measuring current return on investment.


Oculis Holding AG 1-Year ROIIC % Related Terms


Oculis Holding AG 1-Year ROIIC % Historical Data

* Premium members only.

The historical data trend for Oculis Holding AG's 1-Year ROIIC % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Oculis Holding AG 1-Year ROIIC % Chart

Oculis Holding AG Annual Data
Trend Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
1-Year ROIIC %
Get a 7-Day Free Trial -224.77 -262.30 -420.30 -167.81 -926.01

Oculis Holding AG Quarterly Data
Dec20 Sep21 Dec21 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
1-Year ROIIC % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -128.34 -126.43 -125.01 -926.01 -3,592.29

OISE:OCS vs RIGL, GYRE, SGP: 1-Year ROIIC % Comparison

For the Biotechnology subindustry, Oculis Holding AG's 1-Year ROIIC %, along with its competitors' market caps and 1-Year ROIIC % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Oculis Holding AG 1-Year ROIIC % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Oculis Holding AG's 1-Year ROIIC % distribution charts can be found below:

* The bar in red indicates where Oculis Holding AG's 1-Year ROIIC % falls into.


OISE:OCS
26GF Score
Oculis Holding AG OISE:OCS
1-Year ROIIC % is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Oculis Holding AG 1-Year ROIIC % Calculation

Oculis Holding AG's 1-Year ROIIC % for the quarter that ended in Mar. 2026 is calculated as:

1-Year ROIIC %=1-Year Incremental Net Operating Profit After Taxes (NOPAT)**/1-Year Incremental Invested Capital
=( -12925.7646 (Mar. 2026) - -10960.509 (Mar. 2025) )/( 6508.91 (Mar. 2026) - 6454.263 (Mar. 2025) )
=-1965.2556/54.647000000001
=-3,596.27%***

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

** TTM data of NOPAT and Invested Capital was used to calculate 1-Year ROIIC %.
*** Please be aware that the ROIIC (Return on Invested Capital) calculations are based on company-level data using the primary share class. The calculated data provided is for demonstration purposes and may slightly differ from the results displayed in the title due to potential variations caused by currency exchange rate differences throughout the year.

Frequently Asked Questions Learn more about 1-Year ROIIC % →
What does a 1-Year ROIIC % of -3,592.29 mean?
Oculis Holding AG (OISE:OCS) has a 1-Year ROIIC % of -3,592.29 as of Mar. 2026. 1-Year ROIIC % measures the change in earnings as a percentage of change in investment over 1-year. View historical data on Oculis Holding AG and its competitors. According to the industry distribution chart, Oculis Holding AG ranks #1297 out of 1336 companies in the Biotechnology industry, placing it in the top 97.1%.
Is Oculis Holding AG's 1-Year ROIIC % too high?
Oculis Holding AG's current 1-Year ROIIC % is -3,592.29. Based on the distribution chart, Oculis Holding AG ranks #1297 out of 1336 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Oculis Holding AG has a GF Score™ of 26/100, reflecting its overall financial health beyond just this single metric.
How does Oculis Holding AG's 1-Year ROIIC % compare to RIGL and GYRE?
According to the Biotechnology industry distribution chart, Oculis Holding AG ranks #1297 out of 1336 companies for 1-Year ROIIC %. This places Oculis Holding AG in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 1-Year ROIIC % for a Biotechnology company?
A good 1-Year ROIIC % depends on the Biotechnology industry context. However, 1-Year ROIIC % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 1-Year ROIIC % mean?
A high 1-Year ROIIC % can signal that a stock is expensive relative to its fundamentals. 1-Year ROIIC % measures the change in earnings as a percentage of change in investment over 1-year. View historical data on Oculis Holding AG and its competitors. Oculis Holding AG's current 1-Year ROIIC % is -3,592.29. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Oculis Holding AG stock overvalued right now?
Oculis Holding AG (OISE:OCS) has a current 1-Year ROIIC % of -3,592.29. The current 1-Year ROIIC % is -3,592.29. Oculis Holding AG's overall GF Score™ is 26/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 1-Year ROIIC % calculated?
1-Year ROIIC % is calculated from a company's financial statements. For Oculis Holding AG (OISE:OCS), the current 1-Year ROIIC % is -3,592.29 as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Oculis Holding AG Business Description

Other Exchanges OCS:USACR5:Germany
Address Bahnhofstrasse 20, Zug, CHE, CH-6300
Oculis Holding AG is a biopharmaceutical company purposefully driven to save sight and improve eye care. It includes OCS-01, a topical retinal candidate for diabetic macular edema (DME); OCS-02, a topical biologic candidate for dry eye disease (DED); and OCS-05, a disease modifying candidate for acute optic neuritis (AON) and other neuro-ophtha disorders such as glaucoma, diabetic retinopathy, geographic atrophy, and neurotrophic keratitis. The Company has locations in five countries: Switzerland, Iceland, France, U.S. and Hong Kong.
26GF Score

Get the complete analysis for OISE:OCS

1-Year ROIIC % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

kr1,350.00
Price