Aprea TherapeuticsAPRE +2.77%26 3-Year ROIIC % is -9,355.81 as of Dec. 2025. GuruFocus rates APRE with a GF Score™ of 26/100. The stock has 1 warning sign investors should review. Among 1,324 Biotechnology companies, Aprea Therapeutics ranks worse than 99.32% on this metric.
3-Year Return on Invested Incremental Capital (3-Year ROIIC %) measures the change in earnings as a percentage of change in investment over 3-year.
Aprea Therapeutics's 3-Year ROIIC % for the quarter that ended in Dec. 2025 was -9,355.81%. High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
The industry rank for Aprea Therapeutics's 3-Year ROIIC % or its related term are showing as below:
APRE's 3-Year ROIIC % is ranked worse than 99.32% of 1324
companies
in the Biotechnology industry
Industry Median: -4.42
vs APRE: -9355.81
Return on Incremental Invested Capital (ROIIC) is an extension of Return on Investment Capital (ROIC). ROIC % tells investors how efficiently that profitability is earned per dollar of company capital. ROIIC narrows the focus even further and shows how profitable each additional unit of capital investment could be. ROIIC % is a more powerful metric than ROIC because it measures how much money the company can generate going forward on future capital investments.
High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
Be Aware
It's important to keep in mind that when tracking ROIIC, the metric is better suited to forecasting the trend of future returns rather than measuring current return on investment.
Aprea Therapeutics 3-Year ROIIC % Related Terms
Aprea Therapeutics 3-Year ROIIC % Historical Data
* Premium members only.
The historical data trend for Aprea Therapeutics's 3-Year ROIIC % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
APRE vs JSPR, CVKD, BRTX: 3-Year ROIIC % Comparison
For the Biotechnology subindustry, Aprea Therapeutics's 3-Year ROIIC %, along with its competitors' market caps and 3-Year ROIIC % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Aprea Therapeutics 3-Year ROIIC % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Aprea Therapeutics's 3-Year ROIIC % distribution charts can be found below:
* The bar in red indicates where Aprea Therapeutics's 3-Year ROIIC % falls into.
Aprea Therapeutics's 3-Year ROIIC % for the quarter that ended in Dec. 2025 is calculated as:
3-Year ROIIC %
=
3-Year Incremental Net Operating Profit After Taxes (NOPAT)**
/
3-Year Incremental Invested Capital**
=
( -13.234 (Dec. 2025) - -37.372 (Dec. 2022) )
/
( 1.142 (Dec. 2025) - 1.4 (Dec. 2022) )
=
24.138
/
-0.258
=
-9,355.81%***
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
** Annual data of NOPAT and Invested Capital was used to calculate 3-Year ROIIC %.
*** Please be aware that the ROIIC (Return on Invested Capital) calculations are based on company-level data using the primary share class. The calculated data provided is for demonstration purposes and may slightly differ from the results displayed in the title due to potential variations caused by currency exchange rate differences throughout the year.
Aprea Therapeutics (APRE) has a 3-Year ROIIC % of -9,355.81 as of Dec. 2025. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on Aprea Therapeutics and its competitors. According to the industry distribution chart, Aprea Therapeutics ranks #1315 out of 1324 companies in the Biotechnology industry, placing it in the top 99.3%.
Is Aprea Therapeutics' 3-Year ROIIC % too high?
Aprea Therapeutics' current 3-Year ROIIC % is -9,355.81. Based on the distribution chart, Aprea Therapeutics ranks #1315 out of 1324 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Aprea Therapeutics has a GF Score™ of 26/100, reflecting its overall financial health beyond just this single metric.
How does Aprea Therapeutics' 3-Year ROIIC % compare to JSPR and CVKD?
According to the Biotechnology industry distribution chart, Aprea Therapeutics ranks #1315 out of 1324 companies for 3-Year ROIIC %. This places Aprea Therapeutics in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 3-Year ROIIC % for a Biotechnology company?
A good 3-Year ROIIC % depends on the Biotechnology industry context. However, 3-Year ROIIC % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 3-Year ROIIC % mean?
A high 3-Year ROIIC % can signal that a stock is expensive relative to its fundamentals. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on Aprea Therapeutics and its competitors. Aprea Therapeutics's current 3-Year ROIIC % is -9,355.81. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Aprea Therapeutics stock overvalued right now?
Aprea Therapeutics (APRE) has a current 3-Year ROIIC % of -9,355.81. The current 3-Year ROIIC % is -9,355.81. Aprea Therapeutics' overall GF Score™ is 26/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 3-Year ROIIC % calculated?
3-Year ROIIC % is calculated from a company's financial statements. For Aprea Therapeutics (APRE), the current 3-Year ROIIC % is -9,355.81 as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Aprea Therapeutics Inc is a clinical-stage precision medicine oncology company focused on the discovery and development of targeted therapies for patients with biomarker-defined cancers. It develops small molecule inhibitors designed to exploit genetic mutations in cancer to widen the therapeutic window and is intended to make treatments more effective at destroying cancer cells while sparing healthy tissue. The company's pipeline of clinical and preclinical programs includes APR-1051, a WEE1 inhibitor; ATRN-119 (Mosipasertib), an oral small molecule inhibitor of ataxia telangiectasia and Rad3-related, or ATR; and an early-stage program, APR-1602. These candidates are being developed for broad applications in cancer treatment.
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