CalciMedicaCALC -4.42%23 3-Year ROIIC % is 1,760.95 as of Dec. 2025, which is 479% above its 10-year median of 304.06. GuruFocus rates CALC with a GF Score™ of 23/100. The stock has 2 warning signs investors should review. Among 1,324 Biotechnology companies, CalciMedica ranks better than 95.85% on this metric.
3-Year Return on Invested Incremental Capital (3-Year ROIIC %) measures the change in earnings as a percentage of change in investment over 3-year.
CalciMedica's 3-Year ROIIC % for the quarter that ended in Dec. 2025 was 1,760.95%. High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
The industry rank for CalciMedica's 3-Year ROIIC % or its related term are showing as below:
CALC's 3-Year ROIIC % is ranked better than 95.85% of 1324
companies
in the Biotechnology industry
Industry Median: -4.42
vs CALC: 1760.95
CalciMedica (NAS:CALC) 3-Year ROIIC % Explanation
Return on Incremental Invested Capital (ROIIC) is an extension of Return on Investment Capital (ROIC). ROIC % tells investors how efficiently that profitability is earned per dollar of company capital. ROIIC narrows the focus even further and shows how profitable each additional unit of capital investment could be. ROIIC % is a more powerful metric than ROIC because it measures how much money the company can generate going forward on future capital investments.
High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
Be Aware
It's important to keep in mind that when tracking ROIIC, the metric is better suited to forecasting the trend of future returns rather than measuring current return on investment.
CalciMedica 3-Year ROIIC % Related Terms
CalciMedica 3-Year ROIIC % Historical Data
* Premium members only.
The historical data trend for CalciMedica's 3-Year ROIIC % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
CALC vs CRIS, ICU, TRAW: 3-Year ROIIC % Comparison
For the Biotechnology subindustry, CalciMedica's 3-Year ROIIC %, along with its competitors' market caps and 3-Year ROIIC % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
CalciMedica 3-Year ROIIC % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, CalciMedica's 3-Year ROIIC % distribution charts can be found below:
* The bar in red indicates where CalciMedica's 3-Year ROIIC % falls into.
CalciMedica's 3-Year ROIIC % for the quarter that ended in Dec. 2025 is calculated as:
3-Year ROIIC %
=
3-Year Incremental Net Operating Profit After Taxes (NOPAT)**
/
3-Year Incremental Invested Capital**
=
( -23.121 (Dec. 2025) - -14.193 (Dec. 2022) )
/
( 1.311 (Dec. 2025) - 1.818 (Dec. 2022) )
=
-8.928
/
-0.507
=
1,760.95%***
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
** Annual data of NOPAT and Invested Capital was used to calculate 3-Year ROIIC %.
*** Please be aware that the ROIIC (Return on Invested Capital) calculations are based on company-level data using the primary share class. The calculated data provided is for demonstration purposes and may slightly differ from the results displayed in the title due to potential variations caused by currency exchange rate differences throughout the year.
CalciMedica (CALC) has a 3-Year ROIIC % of 1,760.95 as of Dec. 2025. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on CalciMedica and its competitors. This is 479% above median its historical median of 304.06. According to the industry distribution chart, CalciMedica ranks #55 out of 1324 companies in the Biotechnology industry, placing it in the top 4.2%.
Is CalciMedica's 3-Year ROIIC % too high?
CalciMedica's current 3-Year ROIIC % of 1,760.95 is 479% above median its 10-year median of 304.06. Based on the distribution chart, CalciMedica ranks #55 out of 1324 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers. Overall, CalciMedica has a GF Score™ of 23/100, reflecting its overall financial health beyond just this single metric.
How does CalciMedica's 3-Year ROIIC % compare to CRIS and ICU?
According to the Biotechnology industry distribution chart, CalciMedica ranks #55 out of 1324 companies for 3-Year ROIIC %. This places CalciMedica in the top 4% of its industry — outperforming the majority of peers. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 3-Year ROIIC % for a Biotechnology company?
A good 3-Year ROIIC % depends on the Biotechnology industry context. However, 3-Year ROIIC % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 3-Year ROIIC % mean?
A high 3-Year ROIIC % can signal that a stock is expensive relative to its fundamentals. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on CalciMedica and its competitors. CalciMedica's current 3-Year ROIIC % is 1,760.95, which is 479% above median its own 10-year median of 304.06. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is CalciMedica stock overvalued right now?
CalciMedica (CALC) has a current 3-Year ROIIC % of 1,760.95. The current 3-Year ROIIC % is 1,760.95, which is 479% above median its 10-year median of 304.06. CalciMedica's overall GF Score™ is 23/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 3-Year ROIIC % calculated?
3-Year ROIIC % is calculated from a company's financial statements. For CalciMedica (CALC), the current 3-Year ROIIC % is 1,760.95 as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
CalciMedica Inc is a clinical-stage biopharmaceutical company focused on developing therapeutics that treat serious illnesses driven by inflammatory and immunologic processes and direct cellular damage. Its product candidates act upon calcium release-activated calcium (CRAC) channels and would constitute a new class of drugs. Its product candidate is Auxora, a potent and selective intravenous formulated small molecule CRAC channel inhibitor containing the active compound zegocractin (formerly referred to as CM4620) that, in animal models, reduced acute epithelial and/or endothelial cell injury and inflammation in organs, such as the pancreas, lungs and kidneys. The company operates as one operating segment focused on developing and commercializing therapeutics in the U.S.
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