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Ernexa TherapeuticsERNA -9.83%30 3-Year ROIIC % is -242.85 as of Dec. 2025. GuruFocus rates ERNA with a GF Score™ of 30/100. The stock has 4 warning signs investors should review. Among 1,322 Biotechnology companies, Ernexa Therapeutics ranks worse than 81.09% on this metric.
3-Year Return on Invested Incremental Capital (3-Year ROIIC %) measures the change in earnings as a percentage of change in investment over 3-year.
Ernexa Therapeutics's 3-Year ROIIC % for the quarter that ended in Dec. 2025 was -242.85%. High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
The industry rank for Ernexa Therapeutics's 3-Year ROIIC % or its related term are showing as below:
ERNA's 3-Year ROIIC % is ranked worse than 81.09% of 1322
companies
in the Biotechnology industry
Industry Median: -4.835
vs ERNA: -242.85
Return on Incremental Invested Capital (ROIIC) is an extension of Return on Investment Capital (ROIC). ROIC % tells investors how efficiently that profitability is earned per dollar of company capital. ROIIC narrows the focus even further and shows how profitable each additional unit of capital investment could be. ROIIC % is a more powerful metric than ROIC because it measures how much money the company can generate going forward on future capital investments.
High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
Be Aware
It's important to keep in mind that when tracking ROIIC, the metric is better suited to forecasting the trend of future returns rather than measuring current return on investment.
Ernexa Therapeutics 3-Year ROIIC % Related Terms
Ernexa Therapeutics 3-Year ROIIC % Historical Data
* Premium members only.
The historical data trend for Ernexa Therapeutics's 3-Year ROIIC % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
ERNA vs PMCB, SYBX, ASBP: 3-Year ROIIC % Comparison
For the Biotechnology subindustry, Ernexa Therapeutics's 3-Year ROIIC %, along with its competitors' market caps and 3-Year ROIIC % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Ernexa Therapeutics 3-Year ROIIC % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Ernexa Therapeutics's 3-Year ROIIC % distribution charts can be found below:
* The bar in red indicates where Ernexa Therapeutics's 3-Year ROIIC % falls into.
Ernexa Therapeutics's 3-Year ROIIC % for the quarter that ended in Dec. 2025 is calculated as:
3-Year ROIIC %
=
3-Year Incremental Net Operating Profit After Taxes (NOPAT)**
/
3-Year Incremental Invested Capital**
=
( -9.2891792 (Dec. 2025) - -26.947 (Dec. 2022) )
/
( 3.05 (Dec. 2025) - 10.321 (Dec. 2022) )
=
17.6578208
/
-7.271
=
-242.85%***
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
** Annual data of NOPAT and Invested Capital was used to calculate 3-Year ROIIC %.
*** Please be aware that the ROIIC (Return on Invested Capital) calculations are based on company-level data using the primary share class. The calculated data provided is for demonstration purposes and may slightly differ from the results displayed in the title due to potential variations caused by currency exchange rate differences throughout the year.
Ernexa Therapeutics (ERNA) has a 3-Year ROIIC % of -242.85 as of Dec. 2025. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on Ernexa Therapeutics and its competitors. According to the industry distribution chart, Ernexa Therapeutics ranks #1072 out of 1322 companies in the Biotechnology industry, placing it in the top 81.1%.
Is Ernexa Therapeutics' 3-Year ROIIC % too high?
Ernexa Therapeutics' current 3-Year ROIIC % is -242.85. Based on the distribution chart, Ernexa Therapeutics ranks #1072 out of 1322 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Ernexa Therapeutics has a GF Score™ of 30/100, reflecting its overall financial health beyond just this single metric.
How does Ernexa Therapeutics' 3-Year ROIIC % compare to PMCB and SYBX?
According to the Biotechnology industry distribution chart, Ernexa Therapeutics ranks #1072 out of 1322 companies for 3-Year ROIIC %. This places Ernexa Therapeutics in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 3-Year ROIIC % for a Biotechnology company?
A good 3-Year ROIIC % depends on the Biotechnology industry context. However, 3-Year ROIIC % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 3-Year ROIIC % mean?
A high 3-Year ROIIC % can signal that a stock is expensive relative to its fundamentals. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on Ernexa Therapeutics and its competitors. Ernexa Therapeutics's current 3-Year ROIIC % is -242.85. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Ernexa Therapeutics stock overvalued right now?
Ernexa Therapeutics (ERNA) has a current 3-Year ROIIC % of -242.85. The current 3-Year ROIIC % is -242.85. Ernexa Therapeutics' overall GF Score™ is 30/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 3-Year ROIIC % calculated?
3-Year ROIIC % is calculated from a company's financial statements. For Ernexa Therapeutics (ERNA), the current 3-Year ROIIC % is -242.85 as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Ernexa Therapeutics Inc is a preclinical-stage synthetic allogeneic iMSC therapy company developing medicines to treat various forms of cancer and other diseases with high unmet medical needs. Its main product candidate, ERNA-101, capitalizes on the intrinsic tumor-homing ability of MSCs (mesenchymal stem cells) to slip through the tumor's defenses and to deliver potent pro-inflammatory factors directly to the tumor microenvironment. The firm's initial focus is to develop ERNA-101 in platinum-resistant ovarian cancer. Through another product candidate, ERNA-201, it is investigating anti-inflammatory cytokine (IL-10) secreting iMSCs in autoimmune disorders like rheumatoid arthritis. The company operates in a single reportable segment, the research and development of cellular therapies.
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