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Richard Sloan from the University of Michigan was first to document what is referred to as the "accrual anomaly". His 1996 paper found that shares of companies with small or negative accruals vastly outperform (+10%) those of companies with large ones.
Protagonist Therapeutics (NAS:PTGX) Sloan Ratio % Explanation
A former University of Michigan researcher, Richard Sloan's 1996 paper found that shares of companies with small or negative accruals vastly outperform (+10%) those of companies with large ones. In fact, for the 40-year period between 1962 and 2001, buying the lowest accrual companies and shorting the highest accrual companies resulted in an average annual compounded return of 18%, more than double the S&P 500's 7.4% annual return over the same period.
If the Sloan Ratio is between -10% and 10%, the company is in the safe zone and there is no funny business with accruals.
If the Sloan Ratio is less than between -25% and -10% on the negative side, and between 10% and 25% on the positive side, this is a warning stage of accrual build up.
If the Sloan Ratio is less than -25% or greater than 25%, and this ratio is consistent over several quarters or even years, be careful. Earnings are highly likely to be made up of accruals.
As of Jun. 2026, Protagonist Therapeutics has a Sloan Ratio of -14.34%, indicating there is a warning stage of accrual build up.
Protagonist Therapeutics Sloan Ratio % Related Terms
Protagonist Therapeutics Sloan Ratio % Historical Data
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
PTGX vs PRAX, CRNX, PCVX: Sloan Ratio % Comparison
For the Biotechnology subindustry, Protagonist Therapeutics's Sloan Ratio %, along with its competitors' market caps and Sloan Ratio % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Protagonist Therapeutics Sloan Ratio % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Protagonist Therapeutics's Sloan Ratio % distribution charts can be found below:
* The bar in red indicates where Protagonist Therapeutics's Sloan Ratio % falls into.
Protagonist Therapeutics Sloan Ratio % Calculation
Earnings contain a lot of non cash earnings which is called accruals. The Sloan ratio is a way to identify firms with low non-cash or accrual-derived earnings relative to their cash flow.
Protagonist Therapeutics's Sloan Ratio for the fiscal year that ended in Dec. 2025 is calculated as
Protagonist Therapeutics's Net Income for the trailing twelve months (TTM) ended in Jun. 2026 was -39.339 (Sep. 2025 ) + -44.384 (Dec. 2025 ) + 3.783 (Mar. 2026 ) + 162.849 (Jun. 2026 ) = $82.9 Mil.
Protagonist Therapeutics's Cash Flow from Operations for the trailing twelve months (TTM) ended in Jun. 2026 was -1.937 (Sep. 2025 ) + -36.975 (Dec. 2025 ) + -48.943 (Mar. 2026 ) + 219.052 (Jun. 2026 ) = $131.2 Mil.
Protagonist Therapeutics's Cash Flow from Investing for the trailing twelve months (TTM) ended in Jun. 2026 was -58.555 (Sep. 2025 ) + 48.815 (Dec. 2025 ) + 90.892 (Mar. 2026 ) + -2.43 (Jun. 2026 ) = $78.7 Mil.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Protagonist Therapeutics (PTGX) has a Sloan Ratio % of -14.34% as of Jun. 2026. Sloan ratio measures earnings quality based on the amount of accruals. View historical data on Protagonist Therapeutics and its competitors.
Is Protagonist Therapeutics' Sloan Ratio % too high?
Protagonist Therapeutics' current Sloan Ratio % is -14.34%. Overall, Protagonist Therapeutics has a GF Score™ of 53/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Protagonist Therapeutics' Sloan Ratio % compare to PRAX and CRNX?
Protagonist Therapeutics' Sloan Ratio % of -14.34% can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Sloan Ratio % for a Biotechnology company?
A good Sloan Ratio % depends on the Biotechnology industry context. However, Sloan Ratio % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Sloan Ratio % mean?
A high Sloan Ratio % can signal that a stock is expensive relative to its fundamentals. Sloan ratio measures earnings quality based on the amount of accruals. View historical data on Protagonist Therapeutics and its competitors. Protagonist Therapeutics's current Sloan Ratio % is -14.34%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Protagonist Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Protagonist Therapeutics (PTGX) is currently considered Significantly Overvalued. The stock's GF Value™ is $92.84, compared to a current price of $146.49 — trading 57.8% above its estimated fair value. The current Sloan Ratio % is -14.34%. Protagonist Therapeutics' overall GF Score™ is 53/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Sloan Ratio % calculated?
Sloan Ratio % is calculated from a company's financial statements. For Protagonist Therapeutics (PTGX), the current Sloan Ratio % is -14.34% as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Protagonist Therapeutics (PTGX) Overvalued in 2026?
Based on GuruFocus' analysis, Protagonist Therapeutics stock appears to be overvalued.
The current stock price of $146.49 is trading 57.8% above its estimated GF Value™ of $92.84.
GuruFocus considers Protagonist Therapeutics to be Significantly Overvalued.
Key valuation signals for PTGX:
Sloan Ratio %: -14.34%
GF Value™: $92.84 vs. price of $146.49 (57.8% above fair value)
No single metric tells the full story. See the PTGX stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Protagonist Therapeutics Inc is a biopharmaceutical company engaged in the discovery and development of peptide-based therapeutics using its proprietary technology platform. The company focuses on three therapeutic areas: inflammation and immunology, hematology, and metabolic diseases. Its pipeline includes clinical-stage and preclinical candidates such as rusfertide for polycythemia vera, icotrokinra for inflammatory diseases, and other programs targeting IL-17, obesity, and iron metabolism disorders, developed through internal research and strategic collaborations.
53GF Score
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