PTGX (Protagonist Therapeutics) FCF Margin %: -87.21% (As of Mar. 2026)


PTGX Protagonist Therapeutics Inc PTGX
51 GF Score
Price $122.36
GF Value $55.69
Valuation Significantly Overvalued
! 7 Warning Signs
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What is Protagonist Therapeutics FCF Margin %?

Protagonist Therapeutics PTGX +2.92% 51 FCF Margin % is -87.21% as of Mar. 2026. GuruFocus rates PTGX with a GF Score™ of 51/100 and a GF Value™ of $55.69 (Significantly Overvalued). The stock has 7 warning signs investors should review. Among 959 Biotechnology companies, Protagonist Therapeutics ranks worse than 58.19% on this metric.

FCF Margin % is calculated as Free Cash Flow divided by its Revenue. Protagonist Therapeutics's Free Cash Flow for the three months ended in Mar. 2026 was $-49.16 Mil. Protagonist Therapeutics's Revenue for the three months ended in Mar. 2026 was $56.37 Mil. Therefore, Protagonist Therapeutics's FCF Margin % for the quarter that ended in Mar. 2026 was -87.21%.

As of today, Protagonist Therapeutics's current FCF Yield % is -1.50%.

The historical rank and industry rank for Protagonist Therapeutics's FCF Margin % or its related term are showing as below:

PTGX' s FCF Margin % Range Over the Past 10 Years
Min: -18395.67   Med: -163.08   Max: 121.87
Current: -159.18


During the past 12 years, the highest FCF Margin % of Protagonist Therapeutics was 121.87%. The lowest was -18395.67%. And the median was -163.08%.

PTGX's FCF Margin % is ranked worse than
58.19% of 959 companies
in the Biotechnology industry
Industry Median: -84.65 vs PTGX: -159.18


Protagonist Therapeutics FCF Margin % Related Terms


Protagonist Therapeutics FCF Margin % Historical Data

* Premium members only.

The historical data trend for Protagonist Therapeutics's FCF Margin % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Protagonist Therapeutics FCF Margin % Chart

Protagonist Therapeutics Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
FCF Margin %
Get a 7-Day Free Trial Premium Member Only Premium Member Only -398.31 -409.81 -118.08 42.08 121.87

Protagonist Therapeutics Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
FCF Margin % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 440.73 -533.59 -42.98 -499.11 -87.21

PTGX vs SYRE, CELC, MIRM: FCF Margin % Comparison

For the Biotechnology subindustry, Protagonist Therapeutics's FCF Margin %, along with its competitors' market caps and FCF Margin % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Protagonist Therapeutics FCF Margin % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Protagonist Therapeutics's FCF Margin % distribution charts can be found below:

* The bar in red indicates where Protagonist Therapeutics's FCF Margin % falls into.


PTGX
51GF Score
Protagonist Therapeutics Inc PTGX
FCF Margin % is just one metric. See GF Score™, valuation, warning signs, and more.
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Protagonist Therapeutics FCF Margin % Calculation

FCF margin is the ratio of Free Cash Flow divided by net sales or Revenue, usually presented in percent.

Protagonist Therapeutics's FCF Margin for the fiscal year that ended in Dec. 2025 is calculated as

FCF Margin=Free Cash Flow (A: Dec. 2025 )/Revenue (A: Dec. 2025 )
=56.081/46.016
=121.87 %

Protagonist Therapeutics's FCF Margin for the quarter that ended in Mar. 2026 is calculated as

FCF Margin=Free Cash Flow (Q: Mar. 2026 )/Revenue (Q: Mar. 2026 )
=-49.158/56.368
=-87.21 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about FCF Margin % →
What does a FCF Margin % of -87.21% mean?
Protagonist Therapeutics (PTGX) has a FCF Margin % of -87.21% as of Mar. 2026. Free cash flow margin is the ratio of total free cash flow to net sales. View historical data on Protagonist Therapeutics and its competitors. According to the industry distribution chart, Protagonist Therapeutics ranks #558 out of 959 companies in the Biotechnology industry, placing it in the top 58.2%.
Is Protagonist Therapeutics' FCF Margin % too high?
Protagonist Therapeutics' current FCF Margin % is -87.21%. Based on the distribution chart, Protagonist Therapeutics ranks #558 out of 959 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Protagonist Therapeutics has a GF Score™ of 51/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Protagonist Therapeutics' FCF Margin % compare to SYRE and CELC?
According to the Biotechnology industry distribution chart, Protagonist Therapeutics ranks #558 out of 959 companies for FCF Margin %. This places Protagonist Therapeutics in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good FCF Margin % for a Biotechnology company?
A good FCF Margin % depends on the Biotechnology industry context. However, FCF Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high FCF Margin % mean?
A high FCF Margin % can signal that a stock is expensive relative to its fundamentals. Free cash flow margin is the ratio of total free cash flow to net sales. View historical data on Protagonist Therapeutics and its competitors. Protagonist Therapeutics's current FCF Margin % is -87.21%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Protagonist Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Protagonist Therapeutics (PTGX) is currently considered Significantly Overvalued. The stock's GF Value™ is $55.69, compared to a current price of $122.36 — trading 119.7% above its estimated fair value. The current FCF Margin % is -87.21%. Protagonist Therapeutics' overall GF Score™ is 51/100 with 7 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is FCF Margin % calculated?
FCF Margin % is calculated from a company's financial statements. For Protagonist Therapeutics (PTGX), the current FCF Margin % is -87.21% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Protagonist Therapeutics (PTGX) Overvalued in 2026?

Based on GuruFocus' analysis, Protagonist Therapeutics stock appears to be overvalued. The current stock price of $122.36 is trading 119.7% above its estimated GF Value™ of $55.69. GuruFocus considers Protagonist Therapeutics to be Significantly Overvalued.

Key valuation signals for PTGX:

  • FCF Margin %: -87.21%
  • GF Value™: $55.69 vs. price of $122.36 (119.7% above fair value)
  • GF Score™: 51/100 with 7 warning signs

No single metric tells the full story. See the PTGX stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Protagonist Therapeutics Business Description

Address 7707 Gateway Boulevard, Suite 140, Newark, CA, USA, 94560
Protagonist Therapeutics Inc is a biopharmaceutical company engaged in the discovery and development of peptide-based therapeutics using its proprietary technology platform. The company focuses on three therapeutic areas: inflammation and immunology, hematology, and metabolic diseases. Its pipeline includes clinical-stage and preclinical candidates such as rusfertide for polycythemia vera, icotrokinra for inflammatory diseases, and other programs targeting IL-17, obesity, and iron metabolism disorders, developed through internal research and strategic collaborations.
51GF Score

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FCF Margin % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$122.36
Price
$55.69
GF Value