BB
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BAKER BROS. ADVISORS LP13F | |
BAKER BROS. ADVISORS LP | |
Last update 2025-05-16 | 88 Stocks (4 new) |
Value $8.94 Bil | Turnover 2 % |
BAKER BROS. ADVISORS LP Profile
Baker Bros. Advisors is a private hedge fund sponsor that is based out of New York City. The company was established in 2000 by Julian Baker and Felix Baker, who continues to have an active role in the company today acting as its co-managing members. Julian Baker has a business background from Harvard and Felix Baker has a PhD in Immunology from Stanford. The company currently has 25 employees with 11 of them being investment advisory professionals or researchers. Baker Bros. Advisors currently falls into the category of catering to less than 10 clients. The firm utilizes a fundamental driven approach to make its investment decisions, emphasizing life sciences companies. The company holds its investments usually for three years, although its more successful investments are held for longer. Baker Bros. Advisors invests almost exclusively in the health care sector, with a much lesser degree of assets allocated in the industrials sector. The firm’s top holdings currently include Pharmacyclics Inc., which alone makes up almost a fifth of its total asset allocations, Incyte Corporation, Synageva Biopharma Corporation, Seattle Genertics Inc., Salix Pharmaceuticals Inc., Acadia Pharmaceuticals Inc., and Biomarin Pharmaceuticals Inc., with its top ten holdings making up more than three quarters of its total holdings. Baker Bros. Baker Bros. Advisors does not believe in diversifying its portfolio, instead focusing on specific companies that it has deemed to be good holdings and placing concentrated positions in their securities that can generate significant returns in the long term. The company has a current market value of over $12 billion, investing almost all of its total available assets. Advisors’s market value has been increasing significantly over time, growing from its $5 billion market valuation just two years prior in 2013 to well over twice that amount today. Baker Bros. Advisors currently provides its products and services to a variety of university foundations, and families.
BAKER BROS. ADVISORS LP Top Holdings of 2025-03-31
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Ticker | | Company | Shares | Value ($1000) | Shares Change % | Weighting % | Trade Impact % | % of Shares outstanding | 3M Change % | YTD Change % | Market Cap $Mil | Industry |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ONC | BeiGene Ltd | 8,799,053 | 2,394,838.3 | -7.69% | 26.800 | -1.47% | 8.140 | -8.14% | +30.60% | 28,048.0 | Biotechnology | |
INCY | Incyte Corp | 30,739,953 | 1,861,304.1 | 0% | 20.830 | 0% | 15.880 | +12.71% | -0.98% | 13,238.2 | Biotechnology | |
ACAD | ACADIA Pharmaceuticals Inc | 42,877,916 | 712,202.2 | 0% | 7.970 | 0% | 25.620 | +28.68% | +20.54% | 3,702.0 | Biotechnology | |
MDGL | Madrigal Pharmaceuticals Inc | 1,974,590 | 654,043.4 | 0% | 7.320 | 0% | 8.890 | -10.80% | -2.50% | 6,680.1 | Biotechnology | |
SMMT | Summit Therapeutics Inc | 24,424,865 | 471,155.7 | 0% | 5.270 | 0% | 3.290 | 0% | +15.44% | 15,298.9 | Biotechnology | |
INSM | Insmed Inc | 5,380,626 | 410,488.0 | +7.47% | 4.590 | +0.32% | 2.950 | +28.10% | +44.15% | 18,904.0 | Biotechnology | |
RYTM | Rhythm Pharmaceuticals Inc | 5,604,483 | 296,869.5 | -7.89% | 3.320 | -0.29% | 8.810 | +17.26% | +12.04% | 3,990.3 | Biotechnology | |
RVMD | Revolution Medicines Inc | 7,936,972 | 280,651.3 | 0% | 3.140 | 0% | 4.260 | -3.10% | -15.59% | 6,877.0 | Biotechnology | |
KYMR | Kymera Therapeutics Inc | 5,995,929 | 164,108.6 | 0% | 1.840 | 0% | 9.210 | +46.09% | +9.67% | 2,873.1 | Biotechnology | |
ALKS | Alkermes PLC | 4,483,285 | 148,038.1 | +7.21% | 1.660 | +0.11% | 2.720 | -14.12% | +0.12% | 4,748.3 | Drug Manufacturers |
BAKER BROS. ADVISORS LP's Historical Top Holdings Breakdowns
BAKER BROS. ADVISORS LP's Top Stock Picks
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Ticker | | Company | Date | Action | Impact % | Price Range | Price | Price Change from Avrg% | Comment | Current Shares | Share Change |
---|---|---|---|---|---|---|---|---|---|---|---|
ONC | BeiGene Ltd | 2025-03-31 | Reduce Reduce | -1.47% | 175.1 ($233.79) 278.38 | $241.23 | 3.18% | Reduce -7.69% | 8,799,053 | -732,827 | |
IMVT | Immunovant Inc | 2025-03-31 | Add Add | +0.71% | 17.09 ($20.92) 25.19 | $16.10 | -23.04% | Add 219.57% | 5,457,881 | 3,750,000 | |
INSM | Insmed Inc | 2025-03-31 | Add Add | +0.32% | 65.25 ($76.49) 83.83 | $99.52 | 30.11% | Add 7.47% | 5,380,626 | 373,763 | |
RYTM | Rhythm Pharmaceuticals Inc | 2025-03-31 | Reduce Reduce | -0.29% | 48.56 ($55.48) 61.02 | $62.72 | 13.05% | Reduce -7.89% | 5,604,483 | -479,766 | |
KRYS | Krystal Biotech Inc | 2025-03-31 | Sold Out Sold Out | -0.29% | 142.64 ($168.21) 194.44 | $138.88 | -17.44% | Sold Out | 0 | -169,934 | |
CRSP | CRISPR Therapeutics AG | 2025-03-31 | Reduce Reduce | -0.28% | 34.03 ($42.39) 53.02 | $47.49 | 12.03% | Reduce -49.99% | 654,099 | -653,912 | |
IMCR | Immunocore Holdings PLC | 2025-03-31 | Add Add | +0.27% | 28.21 ($30) 33 | $31.19 | 3.97% | Add 53.28% | 2,322,656 | 807,338 | |
XENE | Xenon Pharmaceuticals Inc | 2025-03-31 | Reduce Reduce | -0.27% | 33.55 ($37.97) 40.74 | $32.41 | -14.64% | Reduce -65.04% | 347,408 | -646,271 | |
PCVX | Vaxcyte Inc | 2025-03-31 | Add Add | +0.25% | 37.76 ($79.95) 92.13 | $32.54 | -59.30% | Add 1211.01% | 640,885 | 592,000 | |
ARGX | argenx SE | 2025-03-31 | Reduce Reduce | -0.23% | 571 ($631.12) 671.75 | $560.11 | -11.25% | Reduce -30.51% | 77,760 | -34,144 |
BAKER BROS. ADVISORS LP Total Holding History ($B)
BAKER BROS. ADVISORS LP's Asset Allocation
BAKER BROS. ADVISORS LP Past Portfolios
Portfolio Date | Number of Stocks | New Stocks | Total Value ($Mil) | Q/Q Turnover |
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BAKER BROS. ADVISORS LP's Hypothetical Growth since 2025-03-31
BAKER BROS. ADVISORS LP's Yearly Returns
Year | Portfolio % | % | Excess Gain % |
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BAKER BROS. ADVISORS LP's Holdings Heat Map
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BAKER BROS. ADVISORS LP's Holdings Bubble Chart
BAKER BROS. ADVISORS LP News
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