BB

BAKER BROS. ADVISORS LP

13F
BAKER BROS. ADVISORS LP
Last update 2025-05-16 88 Stocks (4 new)
Value $8.94 Bil Turnover 2 %
Countries:

BAKER BROS. ADVISORS LP Profile

Baker Bros. Advisors is a private hedge fund sponsor that is based out of New York City. The company was established in 2000 by Julian Baker and Felix Baker, who continues to have an active role in the company today acting as its co-managing members. Julian Baker has a business background from Harvard and Felix Baker has a PhD in Immunology from Stanford. The company currently has 25 employees with 11 of them being investment advisory professionals or researchers. Baker Bros. Advisors currently falls into the category of catering to less than 10 clients. The firm utilizes a fundamental driven approach to make its investment decisions, emphasizing life sciences companies. The company holds its investments usually for three years, although its more successful investments are held for longer. Baker Bros. Advisors invests almost exclusively in the health care sector, with a much lesser degree of assets allocated in the industrials sector. The firm’s top holdings currently include Pharmacyclics Inc., which alone makes up almost a fifth of its total asset allocations, Incyte Corporation, Synageva Biopharma Corporation, Seattle Genertics Inc., Salix Pharmaceuticals Inc., Acadia Pharmaceuticals Inc., and Biomarin Pharmaceuticals Inc., with its top ten holdings making up more than three quarters of its total holdings. Baker Bros. Baker Bros. Advisors does not believe in diversifying its portfolio, instead focusing on specific companies that it has deemed to be good holdings and placing concentrated positions in their securities that can generate significant returns in the long term. The company has a current market value of over $12 billion, investing almost all of its total available assets. Advisors’s market value has been increasing significantly over time, growing from its $5 billion market valuation just two years prior in 2013 to well over twice that amount today. Baker Bros. Advisors currently provides its products and services to a variety of university foundations, and families.
BAKER BROS. ADVISORS LP Top Holdings of 2025-03-31 View Full List
Ticker
Company
Shares
Value ($1000)
Shares Change %
Weighting %
Trade Impact %
% of Shares outstanding
3M Change %
YTD Change %
Market Cap $Mil
Industry
ONC
BeiGene Ltd
8,799,053
2,394,838.3
-7.69%
26.800
-1.47%
8.140
-8.14%
+30.60%
28,048.0
Biotechnology
INCY
Incyte Corp
30,739,953
1,861,304.1
0%
20.830
0%
15.880
+12.71%
-0.98%
13,238.2
Biotechnology
ACAD
ACADIA Pharmaceuticals Inc
42,877,916
712,202.2
0%
7.970
0%
25.620
+28.68%
+20.54%
3,702.0
Biotechnology
MDGL
Madrigal Pharmaceuticals Inc
1,974,590
654,043.4
0%
7.320
0%
8.890
-10.80%
-2.50%
6,680.1
Biotechnology
SMMT
Summit Therapeutics Inc
24,424,865
471,155.7
0%
5.270
0%
3.290
0%
+15.44%
15,298.9
Biotechnology
INSM
Insmed Inc
5,380,626
410,488.0
+7.47%
4.590
+0.32%
2.950
+28.10%
+44.15%
18,904.0
Biotechnology
RYTM
Rhythm Pharmaceuticals Inc
5,604,483
296,869.5
-7.89%
3.320
-0.29%
8.810
+17.26%
+12.04%
3,990.3
Biotechnology
RVMD
Revolution Medicines Inc
7,936,972
280,651.3
0%
3.140
0%
4.260
-3.10%
-15.59%
6,877.0
Biotechnology
KYMR
Kymera Therapeutics Inc
5,995,929
164,108.6
0%
1.840
0%
9.210
+46.09%
+9.67%
2,873.1
Biotechnology
ALKS
Alkermes PLC
4,483,285
148,038.1
+7.21%
1.660
+0.11%
2.720
-14.12%
+0.12%
4,748.3
Drug Manufacturers

BAKER BROS. ADVISORS LP's Historical Top Holdings Breakdowns

BAKER BROS. ADVISORS LP's Top Stock Picks View Full List
Ticker
Company
Date
Action
Impact %
Price Range
Price
Price Change from Avrg%
Comment
Current Shares
Share Change
ONC
BeiGene Ltd
2025-03-31
Reduce
Reduce
-1.47%
175.1 ($233.79) 278.38
$241.23
3.18%
Reduce -7.69%
8,799,053
-732,827
IMVT
Immunovant Inc
2025-03-31
Add
Add
+0.71%
17.09 ($20.92) 25.19
$16.10
-23.04%
Add 219.57%
5,457,881
3,750,000
INSM
Insmed Inc
2025-03-31
Add
Add
+0.32%
65.25 ($76.49) 83.83
$99.52
30.11%
Add 7.47%
5,380,626
373,763
RYTM
Rhythm Pharmaceuticals Inc
2025-03-31
Reduce
Reduce
-0.29%
48.56 ($55.48) 61.02
$62.72
13.05%
Reduce -7.89%
5,604,483
-479,766
KRYS
Krystal Biotech Inc
2025-03-31
Sold Out
Sold Out
-0.29%
142.64 ($168.21) 194.44
$138.88
-17.44%
Sold Out
0
-169,934
CRSP
CRISPR Therapeutics AG
2025-03-31
Reduce
Reduce
-0.28%
34.03 ($42.39) 53.02
$47.49
12.03%
Reduce -49.99%
654,099
-653,912
IMCR
Immunocore Holdings PLC
2025-03-31
Add
Add
+0.27%
28.21 ($30) 33
$31.19
3.97%
Add 53.28%
2,322,656
807,338
XENE
Xenon Pharmaceuticals Inc
2025-03-31
Reduce
Reduce
-0.27%
33.55 ($37.97) 40.74
$32.41
-14.64%
Reduce -65.04%
347,408
-646,271
PCVX
Vaxcyte Inc
2025-03-31
Add
Add
+0.25%
37.76 ($79.95) 92.13
$32.54
-59.30%
Add 1211.01%
640,885
592,000
ARGX
argenx SE
2025-03-31
Reduce
Reduce
-0.23%
571 ($631.12) 671.75
$560.11
-11.25%
Reduce -30.51%
77,760
-34,144

BAKER BROS. ADVISORS LP Total Holding History ($B)

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BAKER BROS. ADVISORS LP's Asset Allocation

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BAKER BROS. ADVISORS LP Past Portfolios

Portfolio Date Number of Stocks New Stocks Total Value ($Mil) Q/Q Turnover

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BAKER BROS. ADVISORS LP's Hypothetical Growth since 2025-03-31

BAKER BROS. ADVISORS LP's Yearly Returns

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