Ionis Pharmaceuticals (MIL:1IONS) Buyback Yield %: -3.10 (As of Aug. 02, 2026)

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MIL:1IONS Ionis Pharmaceuticals Inc MIL:1IONS
48 GF Score
Price €48.44
GF Value €44.73
Valuation Modestly Overvalued
! 5 Warning Signs
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What is Ionis Pharmaceuticals Buyback Yield %?

Ionis Pharmaceuticals MIL:1IONS 48 Buyback Yield % is -3.10 as of Aug. 02, 2026. GuruFocus rates MIL:1IONS with a GF Score™ of 48/100 and a GF Value™ of €44.73 (Modestly Overvalued). The stock has 5 warning signs investors should review. Among 735 Biotechnology companies, Ionis Pharmaceuticals ranks better than 65.85% on this metric.

Buyback yield is the net repurchase of shares outstanding over the market capital of the company. It is a measure of shareholder return.

Ionis Pharmaceuticals's current buyback yield was -3.10%.


Ionis Pharmaceuticals Buyback Yield % Historical Data

* Premium members only.

The historical data trend for Ionis Pharmaceuticals's Buyback Yield % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Ionis Pharmaceuticals Buyback Yield % Chart

Ionis Pharmaceuticals Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Buyback Yield %
Get a 7-Day Free Trial Premium Member Only Premium Member Only 0.00 0.00 0.00 0.00 -1.43

Ionis Pharmaceuticals Quarterly Data
Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26 Jun26
Buyback Yield % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -7.95 -0.81 -1.49 -1.99 -2.03

MIL:1IONS vs KYMR, PRAX, HALO: Buyback Yield % Comparison

For the Biotechnology subindustry, Ionis Pharmaceuticals's Buyback Yield %, along with its competitors' market caps and Buyback Yield % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Ionis Pharmaceuticals Buyback Yield % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Ionis Pharmaceuticals's Buyback Yield % distribution charts can be found below:

* The bar in red indicates where Ionis Pharmaceuticals's Buyback Yield % falls into.


MIL:1IONS
48GF Score
Ionis Pharmaceuticals Inc MIL:1IONS
Buyback Yield % is just one metric. See GF Score™, valuation, warning signs, and more.
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Ionis Pharmaceuticals Buyback Yield % Calculation

Buyback yield is a measure of shareholder return.

Ionis Pharmaceuticals's Buyback Yield for the fiscal year that ended in Dec. 2025 is calculated as

Buyback Yield=Net Issuance of Stock / Market Cap
=- (Repurchase of Stock + Issuance of Stock) / Market Cap
=- (0 + 164.484) / 11480.3415
=-1.43%

Ionis Pharmaceuticals's annualized Buyback Yield for the quarter that ended in Jun. 2026 is calculated as

Buyback Yield=Net Issuance of Stock(TTM) / Market Cap
=- (Repurchase of Stock + Issuance of Stock) (TTM)** / Market Cap
=- (0 + 228.459) / 11750.1993
=-1.94%

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

** If the quarter corresponds to the year-end period, we will use the annual Repurchase of Stock and Issuance of Stock data .

Frequently Asked Questions Learn more about Buyback Yield % →
What does a Buyback Yield % of -3.10 mean?
Ionis Pharmaceuticals (MIL:1IONS) has a Buyback Yield % of -3.10 as of Aug. 02, 2026. Share buyback yield equals the net issuance of stock divided by market cap. View historical data on Ionis Pharmaceuticals and its competitors. According to the industry distribution chart, Ionis Pharmaceuticals ranks #251 out of 735 companies in the Biotechnology industry, placing it in the top 34.1%.
Is Ionis Pharmaceuticals' Buyback Yield % too high?
Ionis Pharmaceuticals' current Buyback Yield % is -3.10. Based on the distribution chart, Ionis Pharmaceuticals ranks #251 out of 735 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Ionis Pharmaceuticals has a GF Score™ of 48/100 and is considered Modestly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Ionis Pharmaceuticals' Buyback Yield % compare to KYMR and PRAX?
According to the Biotechnology industry distribution chart, Ionis Pharmaceuticals ranks #251 out of 735 companies for Buyback Yield %. This puts Ionis Pharmaceuticals in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Buyback Yield % for a Biotechnology company?
A good Buyback Yield % depends on the Biotechnology industry context. However, Buyback Yield % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Buyback Yield % mean?
A high Buyback Yield % can signal that a stock is expensive relative to its fundamentals. Share buyback yield equals the net issuance of stock divided by market cap. View historical data on Ionis Pharmaceuticals and its competitors. Ionis Pharmaceuticals's current Buyback Yield % is -3.10. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Ionis Pharmaceuticals stock overvalued right now?
Based on GuruFocus' analysis, Ionis Pharmaceuticals (MIL:1IONS) is currently considered Modestly Overvalued. The stock's GF Value™ is €44.73, compared to a current price of €48.44 — trading 8.3% above its estimated fair value. The current Buyback Yield % is -3.10. Ionis Pharmaceuticals' overall GF Score™ is 48/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Buyback Yield % calculated?
Buyback Yield % is calculated from a company's financial statements. For Ionis Pharmaceuticals (MIL:1IONS), the current Buyback Yield % is -3.10 as of Aug. 02, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Ionis Pharmaceuticals (MIL:1IONS) Overvalued in 2026?

Based on GuruFocus' analysis, Ionis Pharmaceuticals stock appears to be overvalued. The current stock price of €48.44 is trading 8.3% above its estimated GF Value™ of €44.73. GuruFocus considers Ionis Pharmaceuticals to be Modestly Overvalued.

Key valuation signals for MIL:1IONS:

  • Buyback Yield %: -3.10
  • GF Value™: €44.73 vs. price of €48.44 (8.3% above fair value)
  • GF Score™: 48/100 with 5 warning signs

No single metric tells the full story. See the MIL:1IONS stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Ionis Pharmaceuticals Business Description

Other Exchanges IONS:USA0JDI:UKISI:Germany
Address 2855 Gazelle Court, Carlsbad, CA, USA, 92010
Ionis Pharmaceuticals is the leading developer of antisense technology to discover and develop novel drugs. Its broad clinical and preclinical pipeline targets a wide variety of diseases, with an emphasis on cardiovascular, metabolic, neurological, and rare diseases. Ionis and Biogen brought Spinraza to market in 2016 as a treatment for spinal muscular atrophy, and Biogen launched ALS drug Qalsody in 2023. Ionis brought two additional drugs to market via its cardiovascular-focused subsidiary Akcea, including ATTR amyloidosis drug Tegsedi (2018) and cardiology drug Waylivra (Europe, 2019). Ionis and AstraZeneca launched polyneuropathy drug Wainua in 2024. Ionis marked its first two independent launches in 2025 for Tryngolza (for FCS) and Dawnzera (for HAE).
48GF Score

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Buyback Yield % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

€48.44
Price
€44.73
GF Value