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Ionis PharmaceuticalsMIL:1IONS -14.80%48 Cyclically Adjusted PB Ratio is 7.58 as of Sep. 17, 2026, which is 42% below its 10-year median of 13.13. GuruFocus rates MIL:1IONS with a GF Score™ of 48/100 and a GF Value™ of €43.34 (Fairly Valued). The stock has 5 warning signs investors should review. Among 680 Biotechnology companies, Ionis Pharmaceuticals ranks worse than 87.5% on this metric.
The historical rank and industry rank for Ionis Pharmaceuticals's Cyclically Adjusted PB Ratio or its related term are showing as below:
MIL:1IONS'
s Cyclically Adjusted PB Ratio Range Over the Past 10 Years
Min: 5.22 Med: 13.13 Max: 29.73
Current: 9.78
During the past years, Ionis Pharmaceuticals's highest Cyclically Adjusted PB Ratio was 29.73. The lowest was 5.22. And the median was 13.13.
MIL:1IONS's Cyclically Adjusted PB Ratio is ranked worse than 87.5% of 680
companies
in the Biotechnology industry
Industry Median: 1.575
vs MIL:1IONS: 9.78
The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.
Ionis Pharmaceuticals's adjusted book value per share data for the three months ended in Jun. 2026 was €2.322. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is €5.35 for the trailing ten years ended in Jun. 2026.
Shiller PE for Stocks: The True Measure of Stock Valuation
Ionis Pharmaceuticals (MIL:1IONS) Cyclically Adjusted PB Ratio Explanation
Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.
If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.
Ionis Pharmaceuticals Cyclically Adjusted PB Ratio Related Terms
Ionis Pharmaceuticals Cyclically Adjusted PB Ratio Historical Data
* Premium members only.
The historical data trend for Ionis Pharmaceuticals's Cyclically Adjusted PB Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Ionis Pharmaceuticals Cyclically Adjusted PB Ratio Chart
MIL:1IONS vs APGE, CYTK, KRYS: Cyclically Adjusted PB Ratio Comparison
For the Biotechnology subindustry, Ionis Pharmaceuticals's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Ionis Pharmaceuticals Cyclically Adjusted PB Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Ionis Pharmaceuticals's Cyclically Adjusted PB Ratio distribution charts can be found below:
* The bar in red indicates where Ionis Pharmaceuticals's Cyclically Adjusted PB Ratio falls into.
Ionis Pharmaceuticals Cyclically Adjusted PB Ratio Calculation
Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.
The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.
What does a Cyclically Adjusted PB Ratio of 7.58 mean?
Ionis Pharmaceuticals (MIL:1IONS) has a Cyclically Adjusted PB Ratio of 7.58 as of Sep. 17, 2026. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Ionis Pharmaceuticals and its competitors. This is 42% below median its historical median of 13.13. Over the past decade, Ionis Pharmaceuticals' Cyclically Adjusted PB Ratio has ranged from 5.22 to 29.73. According to the industry distribution chart, Ionis Pharmaceuticals ranks #595 out of 680 companies in the Biotechnology industry, placing it in the top 87.5%.
Is Ionis Pharmaceuticals' Cyclically Adjusted PB Ratio too high?
Ionis Pharmaceuticals' current Cyclically Adjusted PB Ratio of 7.58 is 42% below median its 10-year median of 13.13. Over the past 10 years, this metric has ranged from a low of 5.22 to a high of 29.73. The Biotechnology industry median Cyclically Adjusted PB Ratio is 1.58. Ionis Pharmaceuticals' value of 7.58 is 381.3% above this industry median. Based on the distribution chart, Ionis Pharmaceuticals ranks #595 out of 680 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Ionis Pharmaceuticals has a GF Score™ of 48/100 and is considered Fairly Valued, reflecting its overall financial health beyond just this single metric.
How does Ionis Pharmaceuticals' Cyclically Adjusted PB Ratio compare to APGE and CYTK?
According to the Biotechnology industry distribution chart, Ionis Pharmaceuticals ranks #595 out of 680 companies for Cyclically Adjusted PB Ratio. This places Ionis Pharmaceuticals in the lower half of its industry. The industry median Cyclically Adjusted PB Ratio is 1.58. Ionis Pharmaceuticals' value of 7.58 is 381.3% above this benchmark. Historically, Ionis Pharmaceuticals' own Cyclically Adjusted PB Ratio has ranged from 5.22 to 29.73 over the past decade. While the company's 10-year median is 13.13 vs. the industry median of 1.58, Ionis Pharmaceuticals has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PB Ratio for a Biotechnology company?
The median Cyclically Adjusted PB Ratio among Biotechnology companies is 1.58, based on 680 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Ionis Pharmaceuticals's current Cyclically Adjusted PB Ratio of 7.58 is 381.3% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PB Ratio mean?
A high Cyclically Adjusted PB Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Ionis Pharmaceuticals and its competitors. For the Biotechnology industry, the median Cyclically Adjusted PB Ratio is 1.58 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Ionis Pharmaceuticals's current Cyclically Adjusted PB Ratio is 7.58, which is 42% below median its own 10-year median of 13.13. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Ionis Pharmaceuticals stock overvalued right now?
Based on GuruFocus' analysis, Ionis Pharmaceuticals (MIL:1IONS) is currently considered Fairly Valued. The stock's GF Value™ is €43.34, compared to a current price of €40.52 — trading 6.5% below its estimated fair value. The current Cyclically Adjusted PB Ratio is 7.58, which is 42% below median its 10-year median of 13.13 and 381.3% above the Biotechnology industry median of 1.58. Ionis Pharmaceuticals' overall GF Score™ is 48/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PB Ratio calculated?
Cyclically Adjusted PB Ratio is calculated from a company's financial statements. For Ionis Pharmaceuticals (MIL:1IONS), the current Cyclically Adjusted PB Ratio is 7.58 as of Sep. 17, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Ionis Pharmaceuticals (MIL:1IONS) Overvalued in 2026?
Based on GuruFocus' analysis, Ionis Pharmaceuticals stock appears to be undervalued.
The current stock price of €40.52 is trading 6.5% below its estimated GF Value™ of €43.34.
GuruFocus considers Ionis Pharmaceuticals to be Fairly Valued.
Key valuation signals for MIL:1IONS:
Cyclically Adjusted PB Ratio: 7.58 (42% below median its 10-year median of 13.13)
GF Value™: €43.34 vs. price of €40.52 (6.5% below fair value)
Industry Position: 381.3% above the Biotechnology median (#595 of 680)
No single metric tells the full story. See the MIL:1IONS stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Ionis Pharmaceuticals is the leading developer of antisense technology to discover and develop novel drugs. Its broad clinical and preclinical pipeline targets a wide variety of diseases, with an emphasis on cardiovascular, metabolic, neurological, and rare diseases. Ionis and Biogen brought Spinraza to market in 2016 as a treatment for spinal muscular atrophy, and Biogen launched ALS drug Qalsody in 2023. Ionis brought two additional drugs to market via its cardiovascular-focused subsidiary Akcea, including ATTR amyloidosis drug Tegsedi (2018) and cardiology drug Waylivra (Europe, 2019). Ionis and AstraZeneca launched polyneuropathy drug Wainua in 2024. Ionis marked its first two independent launches in 2025 for Tryngolza (for FCS) and Dawnzera (for HAE).
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