Alnylam Pharmaceuticals (MEX:ALNY) Cyclically Adjusted Book per Share: MXN157.06 (As of Jun. 2026)

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MEX:ALNY Alnylam Pharmaceuticals Inc MEX:ALNY
65 GF Score
Price MXN5,549.00
GF Value MXN11,444.89
! 1 Warning Sign
View Full Analysis

What is Alnylam Pharmaceuticals Cyclically Adjusted Book per Share?

Alnylam Pharmaceuticals MEX:ALNY 65 Cyclically Adjusted Book per Share is MXN157.06 as of Jun. 2026. GuruFocus rates MEX:ALNY with a GF Score™ of 65/100 and a GF Value™ of MXN11,444.89. The stock has 1 warning sign investors should review.

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted Book per Share and the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years.

Alnylam Pharmaceuticals's adjusted book value per share for the three months ended in Jun. 2026 was MXN176.679. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is MXN157.06 for the trailing ten years ended in Jun. 2026.

During the past 12 months, Alnylam Pharmaceuticals's average Cyclically Adjusted Book Growth Rate was -9.70% per year. During the past 3 years, the average Cyclically Adjusted Book Growth Rate was -9.70% per year. During the past 5 years, the average Cyclically Adjusted Book Growth Rate was -3.50% per year. During the past 10 years, the average Cyclically Adjusted Book Growth Rate was 5.10% per year. Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the Cyclically Adjusted Book Growth Rate using Cyclically Adjusted Book per Share data.

During the past 13 years, the highest 3-Year average Cyclically Adjusted Book Growth Rate of Alnylam Pharmaceuticals was 23.40% per year. The lowest was -9.70% per year. And the median was 10.90% per year.

As of today (2026-09-09), Alnylam Pharmaceuticals's current stock price is MXN5549.00. Alnylam Pharmaceuticals's Cyclically Adjusted Book per Share for the quarter that ended in Jun. 2026 was MXN157.06. Alnylam Pharmaceuticals's Cyclically Adjusted PB Ratio of today is 35.33.

During the past 13 years, the highest Cyclically Adjusted PB Ratio of Alnylam Pharmaceuticals was 49.35. The lowest was 4.66. And the median was 13.43.


Alnylam Pharmaceuticals  (MEX:ALNY) Cyclically Adjusted Book per Share Explanation

If a company grows much fast than inflation, Cyclically Adjusted Book per Share may underestimate the company's equity. Cyclically Adjusted PB Ratio can seem to be too high even the actual PB Ratio is low.

For the Cyclically Adjusted PB Ratio, the book value of the past 10 years are inflation-adjusted and averaged. The result is used for P/B calculation. Since it looks at the average over the last 10 years, the Cyclically Adjusted PB Ratio is also called CAPB Ratio.

The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.

Alnylam Pharmaceuticals's Cyclically Adjusted PB Ratio of today is calculated as

Cyclically Adjusted PB Ratio=Share Price/Cyclically Adjusted Book per Share
=5549.00/157.06
=35.33

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

During the past 13 years, the highest Cyclically Adjusted PB Ratio of Alnylam Pharmaceuticals was 49.35. The lowest was 4.66. And the median was 13.43.


Be Aware

Cyclically Adjusted PB Ratio works better for cyclical companies. It gives you a better idea on the company's real book value.


Alnylam Pharmaceuticals Cyclically Adjusted Book per Share Related Terms


Alnylam Pharmaceuticals Cyclically Adjusted Book per Share Historical Data

* Premium members only.

The historical data trend for Alnylam Pharmaceuticals's Cyclically Adjusted Book per Share can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Alnylam Pharmaceuticals Cyclically Adjusted Book per Share Chart

Alnylam Pharmaceuticals Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Cyclically Adjusted Book per Share
Get a 7-Day Free Trial Premium Member Only Premium Member Only 281.44 250.81 207.90 229.68 197.46

Alnylam Pharmaceuticals Quarterly Data
Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26 Jun26
Cyclically Adjusted Book per Share Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 152.82 179.36 197.46 234.78 157.06

MEX:ALNY vs RPRX, INSM, BNTX: Cyclically Adjusted Book per Share Comparison

For the Biotechnology subindustry, Alnylam Pharmaceuticals's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Alnylam Pharmaceuticals Cyclically Adjusted PB Ratio vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Alnylam Pharmaceuticals's Cyclically Adjusted PB Ratio distribution charts can be found below:

* The bar in red indicates where Alnylam Pharmaceuticals's Cyclically Adjusted PB Ratio falls into.


MEX:ALNY
65GF Score
Alnylam Pharmaceuticals Inc MEX:ALNY
Cyclically Adjusted Book per Share is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Alnylam Pharmaceuticals Cyclically Adjusted Book per Share Calculation

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted Book per Share and the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years.

What is Cyclically Adjusted Book per Share? How do we calculate Cyclically Adjusted Book per Share?

Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years. Let's use an example to explain.

If we want to calculate the Cyclically Adjusted Book per Share of Wal-Mart (WMT) for Dec. 31, 2010, we need to have the inflation data and the book value per share from 2001 through 2010.

We adjusted the 2001 book value per share data with the total inflation from 2001 through 2010 to the equivalent book value in 2010. If the total inflation from 2001 to 2010 is 40%, and Wal-Mart's book value is $1 a share in 2001, then the 2001's equivalent book value in 2010 is $1.4 a share. If Wal-Mart's book value is $1 again in 2002, and the total inflation from 2002 through 2010 is 35%, then the equivalent 2002 book value in 2010 is $1.35. So on and so forth, you get the equivalent book value per share of past 10 years. Then you add them together and divided the sum by the count to get Cyclically Adjusted Book per Share.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

For example, Alnylam Pharmaceuticals's adjusted Book Value per Share data for the three months ended in Jun. 2026 was:

Adj_Book= Book Value per Share /CPI of Jun. 2026 (Change)*Current CPI (Jun. 2026)
=176.679/333.9520*333.9520
=176.679

Current CPI (Jun. 2026) = 333.9520.

Alnylam Pharmaceuticals Quarterly Data

Book Value per Share CPI Adj_Book
201609 228.819 241.428 316.511
201612 220.758 241.432 305.355
201703 181.775 243.801 248.990
201706 221.358 244.955 301.782
201709 208.035 246.819 281.476
201712 348.077 246.524 471.520
201803 317.321 249.554 424.637
201806 316.678 251.989 419.682
201809 273.831 252.439 362.252
201812 252.667 251.233 335.858
201903 282.034 254.202 370.516
201906 303.776 256.143 396.055
201909 284.995 256.759 370.677
201912 241.859 256.974 314.309
202003 279.659 258.115 361.826
202006 279.373 257.797 361.902
202009 231.104 260.280 296.518
202012 173.630 260.474 222.610
202103 161.371 264.877 203.454
202106 143.234 271.696 176.054
202109 130.086 274.310 158.370
202112 100.401 278.802 120.261
202203 66.162 287.504 76.851
202206 29.271 296.311 32.989
202209 -11.062 296.808 -12.446
202212 -24.892 296.797 -28.008
202303 -37.611 301.836 -41.613
202306 -56.020 305.109 -61.316
202309 -23.030 307.789 -24.988
202312 -29.773 306.746 -32.414
202403 -28.776 312.332 -30.768
202406 -0.439 314.175 -0.467
202409 4.945 315.301 5.238
202412 10.822 315.605 11.451
202503 18.123 319.799 18.925
202506 36.025 322.561 37.297
202509 32.556 324.800 33.473
202512 107.343 324.054 110.622
202603 145.319 330.213 146.964
202606 176.679 333.952 176.679

Add all the adjusted book value per share together and divide the count will get our Cyclically Adjusted Book per Share.

What does a Cyclically Adjusted Book per Share of MXN157.06 mean?
Alnylam Pharmaceuticals (MEX:ALNY) has a Cyclically Adjusted Book per Share of MXN157.06 as of Jun. 2026. Cyclically adjusted book value per share represents the company's inflation-adjusted book value per share over a 10-year period. View historical data on Alnylam Pharmaceuticals and its competitors.
Is Alnylam Pharmaceuticals' Cyclically Adjusted Book per Share too high?
Alnylam Pharmaceuticals' current Cyclically Adjusted Book per Share is MXN157.06. Overall, Alnylam Pharmaceuticals has a GF Score™ of 65/100, reflecting its overall financial health beyond just this single metric.
How does Alnylam Pharmaceuticals' Cyclically Adjusted Book per Share compare to RPRX and INSM?
Alnylam Pharmaceuticals' Cyclically Adjusted Book per Share of MXN157.06 can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted Book per Share for a Biotechnology company?
A good Cyclically Adjusted Book per Share depends on the Biotechnology industry context. However, Cyclically Adjusted Book per Share should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted Book per Share mean?
A high Cyclically Adjusted Book per Share can signal that a stock is expensive relative to its fundamentals. Cyclically adjusted book value per share represents the company's inflation-adjusted book value per share over a 10-year period. View historical data on Alnylam Pharmaceuticals and its competitors. Alnylam Pharmaceuticals's current Cyclically Adjusted Book per Share is MXN157.06. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Alnylam Pharmaceuticals stock overvalued right now?
Alnylam Pharmaceuticals (MEX:ALNY) has a current Cyclically Adjusted Book per Share of MXN157.06. The stock's GF Value™ is MXN11,444.89, compared to a current price of MXN5,549.00 — trading 51.5% below its estimated fair value. The current Cyclically Adjusted Book per Share is MXN157.06. Alnylam Pharmaceuticals' overall GF Score™ is 65/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted Book per Share calculated?
Cyclically Adjusted Book per Share is calculated from a company's financial statements. For Alnylam Pharmaceuticals (MEX:ALNY), the current Cyclically Adjusted Book per Share is MXN157.06 as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Alnylam Pharmaceuticals (MEX:ALNY) Overvalued in 2026?

Based on GuruFocus' analysis, Alnylam Pharmaceuticals stock appears to be undervalued. The current stock price of MXN5,549.00 is trading 51.5% below its estimated GF Value™ of MXN11,444.89.

Key valuation signals for MEX:ALNY:

  • Cyclically Adjusted Book per Share: MXN157.06
  • GF Value™: MXN11,444.89 vs. price of MXN5,549.00 (51.5% below fair value)
  • GF Score™: 65/100 with 1 warning sign

No single metric tells the full story. See the MEX:ALNY stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Alnylam Pharmaceuticals Business Description

Address 675 West Kendall Street, Henri A. Termeer Square, Cambridge, MA, USA, 02142
Alnylam Pharmaceuticals is a leader in the study of RNA interference (RNAi) therapeutics. RNAi is a naturally occurring biological pathway within cells for sequence-specific silencing and regulation of gene expression. Alnylam's commercial RNAi therapeutic products include Onpattro and Amvuttra (for hATTR amyloidosis), Givlaari (for acute hepatic porphyria), and Oxlumo (for primary hyperoxaluria type 1), all developed and commercialized by Alnylam. Plus, Leqvio (for hypercholesterolemia) and Qfitlia (for hemophilia A or B), which are being commercialized by Alnylam's partners, Novartis and Sanofi, respectively. It also has several clinical programs across various therapeutic areas, including cardio-metabolic diseases, neuroscience, and hematology.
65GF Score

Get the complete analysis for MEX:ALNY

Cyclically Adjusted Book per Share is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

MXN5,549.00
Price
MXN11,444.89
GF Value