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Anavex Life SciencesAVXL +2.14%30 Cyclically Adjusted PB Ratio is 2.08 as of Jul. 18, 2026. GuruFocus rates AVXL with a GF Score™ of 30/100. The stock has 1 warning sign investors should review. Among 697 Biotechnology companies, Anavex Life Sciences ranks worse than 56.53% on this metric.
The historical rank and industry rank for Anavex Life Sciences's Cyclically Adjusted PB Ratio or its related term are showing as below:
AVXL'
s Cyclically Adjusted PB Ratio Range Over the Past 10 Years
Min: 0 Med: 0 Max: 2.08
Current: 2.08
During the past years, Anavex Life Sciences's highest Cyclically Adjusted PB Ratio was 2.08. The lowest was 0.00. And the median was 0.00.
AVXL's Cyclically Adjusted PB Ratio is ranked worse than 56.53% of 697
companies
in the Biotechnology industry
Industry Median: 1.63
vs AVXL: 2.08
The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.
Anavex Life Sciences's adjusted book value per share data for the three months ended in Dec. 2025 was $1.366. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is $1.15 for the trailing ten years ended in Dec. 2025.
Shiller PE for Stocks: The True Measure of Stock Valuation
Anavex Life Sciences (NAS:AVXL) Cyclically Adjusted PB Ratio Explanation
Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.
If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.
Anavex Life Sciences Cyclically Adjusted PB Ratio Related Terms
Anavex Life Sciences Cyclically Adjusted PB Ratio Historical Data
* Premium members only.
The historical data trend for Anavex Life Sciences's Cyclically Adjusted PB Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Anavex Life Sciences Cyclically Adjusted PB Ratio Chart
AVXL vs SLGL, FATE, FHTX: Cyclically Adjusted PB Ratio Comparison
For the Biotechnology subindustry, Anavex Life Sciences's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Anavex Life Sciences Cyclically Adjusted PB Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Anavex Life Sciences's Cyclically Adjusted PB Ratio distribution charts can be found below:
* The bar in red indicates where Anavex Life Sciences's Cyclically Adjusted PB Ratio falls into.
Anavex Life Sciences Cyclically Adjusted PB Ratio Calculation
Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.
The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.
What does a Cyclically Adjusted PB Ratio of 2.08 mean?
Anavex Life Sciences (AVXL) has a Cyclically Adjusted PB Ratio of 2.08 as of Jul. 18, 2026. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Anavex Life Sciences and its competitors. According to the industry distribution chart, Anavex Life Sciences ranks #394 out of 697 companies in the Biotechnology industry, placing it in the top 56.5%.
Is Anavex Life Sciences' Cyclically Adjusted PB Ratio too high?
Anavex Life Sciences' current Cyclically Adjusted PB Ratio is 2.08. The Biotechnology industry median Cyclically Adjusted PB Ratio is 1.63. Anavex Life Sciences' value of 2.08 is 27.6% above this industry median. Based on the distribution chart, Anavex Life Sciences ranks #394 out of 697 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Anavex Life Sciences has a GF Score™ of 30/100, reflecting its overall financial health beyond just this single metric.
How does Anavex Life Sciences' Cyclically Adjusted PB Ratio compare to SLGL and FATE?
According to the Biotechnology industry distribution chart, Anavex Life Sciences ranks #394 out of 697 companies for Cyclically Adjusted PB Ratio. This places Anavex Life Sciences in the lower half of its industry. The industry median Cyclically Adjusted PB Ratio is 1.63. Anavex Life Sciences' value of 2.08 is 27.6% above this benchmark. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PB Ratio for a Biotechnology company?
The median Cyclically Adjusted PB Ratio among Biotechnology companies is 1.63, based on 697 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Anavex Life Sciences's current Cyclically Adjusted PB Ratio of 2.08 is 27.6% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PB Ratio mean?
A high Cyclically Adjusted PB Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Anavex Life Sciences and its competitors. For the Biotechnology industry, the median Cyclically Adjusted PB Ratio is 1.63 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Anavex Life Sciences's current Cyclically Adjusted PB Ratio is 2.08. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Anavex Life Sciences stock overvalued right now?
Anavex Life Sciences (AVXL) has a current Cyclically Adjusted PB Ratio of 2.08. The current Cyclically Adjusted PB Ratio is 2.08 and 27.6% above the Biotechnology industry median of 1.63. Anavex Life Sciences' overall GF Score™ is 30/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PB Ratio calculated?
Cyclically Adjusted PB Ratio is calculated from a company's financial statements. For Anavex Life Sciences (AVXL), the current Cyclically Adjusted PB Ratio is 2.08 as of Jul. 18, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Anavex Life Sciences Corp is a clinical stage biopharmaceutical company engaged in the development of differentiated therapeutics by applying precision medicine to central nervous system(CNS) diseases with high unmet need. It analyzes genomic data from clinical trials to identify biomarkers, which are used in the analysis of its clinical trials for the treatment of neurodegenerative and neurodevelopmental diseases. The company focuses on developing treatments for Alzheimer's disease, Parkinson's disease, schizophrenia, neurodevelopmental, neurodegenerative, and rare diseases, including Rett syndrome, and other central nervous system (CNS) disorders. Its pipeline includes ANAVEX 2-73 and ANAVEX 3-71 and several other compounds in different stages of clinical and pre-clinical development.
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