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ProMIS NeurosciencesFRA:23J -1.65%38 Cyclically Adjusted PB Ratio is 4.96 as of Aug. 25, 2026, which is 35% below its 10-year median of 7.65. GuruFocus rates FRA:23J with a GF Score™ of 38/100. The stock has 1 warning sign investors should review. Among 685 Biotechnology companies, ProMIS Neurosciences ranks worse than 71.24% on this metric.
The historical rank and industry rank for ProMIS Neurosciences's Cyclically Adjusted PB Ratio or its related term are showing as below:
FRA:23J'
s Cyclically Adjusted PB Ratio Range Over the Past 10 Years
Min: 1.06 Med: 7.65 Max: 46.03
Current: 4.2
During the past years, ProMIS Neurosciences's highest Cyclically Adjusted PB Ratio was 46.03. The lowest was 1.06. And the median was 7.65.
FRA:23J's Cyclically Adjusted PB Ratio is ranked worse than 71.24% of 685
companies
in the Biotechnology industry
Industry Median: 1.62
vs FRA:23J: 4.20
The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.
ProMIS Neurosciences's adjusted book value per share data for the three months ended in Jun. 2026 was €4.781. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is €2.40 for the trailing ten years ended in Jun. 2026.
Shiller PE for Stocks: The True Measure of Stock Valuation
ProMIS Neurosciences (FRA:23J) Cyclically Adjusted PB Ratio Explanation
Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.
If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.
ProMIS Neurosciences Cyclically Adjusted PB Ratio Related Terms
ProMIS Neurosciences Cyclically Adjusted PB Ratio Historical Data
* Premium members only.
The historical data trend for ProMIS Neurosciences's Cyclically Adjusted PB Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
ProMIS Neurosciences Cyclically Adjusted PB Ratio Chart
FRA:23J vs FBIO, VANI, SEER: Cyclically Adjusted PB Ratio Comparison
For the Biotechnology subindustry, ProMIS Neurosciences's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
ProMIS Neurosciences Cyclically Adjusted PB Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, ProMIS Neurosciences's Cyclically Adjusted PB Ratio distribution charts can be found below:
* The bar in red indicates where ProMIS Neurosciences's Cyclically Adjusted PB Ratio falls into.
ProMIS Neurosciences Cyclically Adjusted PB Ratio Calculation
Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.
The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.
What does a Cyclically Adjusted PB Ratio of 4.96 mean?
ProMIS Neurosciences (FRA:23J) has a Cyclically Adjusted PB Ratio of 4.96 as of Aug. 25, 2026. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on ProMIS Neurosciences and its competitors. This is 35% below median its historical median of 7.65. Over the past decade, ProMIS Neurosciences' Cyclically Adjusted PB Ratio has ranged from 1.06 to 46.03. According to the industry distribution chart, ProMIS Neurosciences ranks #488 out of 685 companies in the Biotechnology industry, placing it in the top 71.2%.
Is ProMIS Neurosciences' Cyclically Adjusted PB Ratio too high?
ProMIS Neurosciences' current Cyclically Adjusted PB Ratio of 4.96 is 35% below median its 10-year median of 7.65. Over the past 10 years, this metric has ranged from a low of 1.06 to a high of 46.03. The Biotechnology industry median Cyclically Adjusted PB Ratio is 1.62. ProMIS Neurosciences' value of 4.96 is 206.2% above this industry median. Based on the distribution chart, ProMIS Neurosciences ranks #488 out of 685 companies in the Biotechnology industry, which is below the industry midpoint. Overall, ProMIS Neurosciences has a GF Score™ of 38/100, reflecting its overall financial health beyond just this single metric.
How does ProMIS Neurosciences' Cyclically Adjusted PB Ratio compare to FBIO and VANI?
According to the Biotechnology industry distribution chart, ProMIS Neurosciences ranks #488 out of 685 companies for Cyclically Adjusted PB Ratio. This places ProMIS Neurosciences in the lower half of its industry. The industry median Cyclically Adjusted PB Ratio is 1.62. ProMIS Neurosciences' value of 4.96 is 206.2% above this benchmark. Historically, ProMIS Neurosciences' own Cyclically Adjusted PB Ratio has ranged from 1.06 to 46.03 over the past decade. While the company's 10-year median is 7.65 vs. the industry median of 1.62, ProMIS Neurosciences has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PB Ratio for a Biotechnology company?
The median Cyclically Adjusted PB Ratio among Biotechnology companies is 1.62, based on 685 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. ProMIS Neurosciences's current Cyclically Adjusted PB Ratio of 4.96 is 206.2% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PB Ratio mean?
A high Cyclically Adjusted PB Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on ProMIS Neurosciences and its competitors. For the Biotechnology industry, the median Cyclically Adjusted PB Ratio is 1.62 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. ProMIS Neurosciences's current Cyclically Adjusted PB Ratio is 4.96, which is 35% below median its own 10-year median of 7.65. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is ProMIS Neurosciences stock overvalued right now?
ProMIS Neurosciences (FRA:23J) has a current Cyclically Adjusted PB Ratio of 4.96. The current Cyclically Adjusted PB Ratio is 4.96, which is 35% below median its 10-year median of 7.65 and 206.2% above the Biotechnology industry median of 1.62. ProMIS Neurosciences' overall GF Score™ is 38/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PB Ratio calculated?
Cyclically Adjusted PB Ratio is calculated from a company's financial statements. For ProMIS Neurosciences (FRA:23J), the current Cyclically Adjusted PB Ratio is 4.96 as of Aug. 25, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
ProMIS Neurosciences Inc is a clinical-stage biotechnology company focused on generating and developing antibody therapeutics selectively targeting toxic misfolded proteins in neurodegenerative diseases such as Alzheimers disease (AD), amyotrophic lateral sclerosis (ALS), and multiple system atrophy (MSA). The company applies its thermodynamic, computational discovery platform, ProMIS, and Collective Coordinates to predict novel targets known as Disease Specific Epitopes on the molecular surface of misfolded proteins. Compnies product candidates are PMN310, PMN267, and PMN442. Lead product candidate is PMN310, a monoclonal antibody designed to treat AD by selectively targeting toxic, misfolded oligomers of amyloid-beta. PMN267 is companies second lead product candidate targeting ALS.
38GF Score
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