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ProQR Therapeutics NVPRQR -3.91%48 Cyclically Adjusted PS Ratio is 13.23 as of Jul. 25, 2026, which is 37% below its 10-year median of 20.97. GuruFocus rates PRQR with a GF Scoreâ„¢ of 48/100 and a GF Valueâ„¢ of $2.05 (Modestly Undervalued). The stock has 4 warning signs investors should review. Among 538 Biotechnology companies, ProQR Therapeutics NV ranks worse than 72.68% on this metric.
The historical rank and industry rank for ProQR Therapeutics NV's Cyclically Adjusted PS Ratio or its related term are showing as below:
PRQR'
s Cyclically Adjusted PS Ratio Range Over the Past 10 Years
Min: 9.33 Med: 20.97 Max: 57.5
Current: 13.67
During the past years, ProQR Therapeutics NV's highest Cyclically Adjusted PS Ratio was 57.50. The lowest was 9.33. And the median was 20.97.
PRQR's Cyclically Adjusted PS Ratio is ranked worse than 72.68% of 538
companies
in the Biotechnology industry
Industry Median: 5.65
vs PRQR: 13.67
The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PS Ratio. The Cyclically Adjusted Revenue per Share is the average of the inflation adjusted revenue per share of a company over the past 10 years.
ProQR Therapeutics NV's adjusted revenue per share data for the three months ended in Mar. 2026 was $0.022. Add all the adjusted revenue per share for the past 10 years together and divide 10 will get our Cyclically Adjusted Revenue per Share, which is $0.13 for the trailing ten years ended in Mar. 2026.
Shiller PE for Stocks: The True Measure of Stock Valuation
ProQR Therapeutics NV (NAS:PRQR) Cyclically Adjusted PS Ratio Explanation
Compared with the regular PS Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PS Ratio smoothed out the fluctuations of revenue during business cycles. Therefore it is more accurate in reflecting the valuation of the company.
If a company has consistent business performance, the Cyclically Adjusted PS Ratio should give similar results to regular PS Ratio.
ProQR Therapeutics NV Cyclically Adjusted PS Ratio Related Terms
ProQR Therapeutics NV Cyclically Adjusted PS Ratio Historical Data
* Premium members only.
The historical data trend for ProQR Therapeutics NV's Cyclically Adjusted PS Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
ProQR Therapeutics NV Cyclically Adjusted PS Ratio Chart
PRQR vs CRBP, NRXP, CRBU: Cyclically Adjusted PS Ratio Comparison
For the Biotechnology subindustry, ProQR Therapeutics NV's Cyclically Adjusted PS Ratio, along with its competitors' market caps and Cyclically Adjusted PS Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
ProQR Therapeutics NV Cyclically Adjusted PS Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, ProQR Therapeutics NV's Cyclically Adjusted PS Ratio distribution charts can be found below:
* The bar in red indicates where ProQR Therapeutics NV's Cyclically Adjusted PS Ratio falls into.
ProQR Therapeutics NV Cyclically Adjusted PS Ratio Calculation
Like the Shiller PE Ratio, the Cyclically Adjusted PS Ratio takes the Revenue per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/S calculation. Because it considers this 10-year average, it's often referred to as the CAPS Ratio.
The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PS Ratio.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.
What does a Cyclically Adjusted PS Ratio of 13.23 mean?
ProQR Therapeutics NV (PRQR) has a Cyclically Adjusted PS Ratio of 13.23 as of Jul. 25, 2026. Cyclically Adjusted PS Ratio is the ratio of share price to a company's inflation-adjusted revenue per share over a 10-year period. View historical data on ProQR Therapeutics NV and its competitors. This is 37% below median its historical median of 20.97. Over the past decade, ProQR Therapeutics NV's Cyclically Adjusted PS Ratio has ranged from 9.33 to 57.50. According to the industry distribution chart, ProQR Therapeutics NV ranks #391 out of 538 companies in the Biotechnology industry, placing it in the top 72.7%.
Is ProQR Therapeutics NV's Cyclically Adjusted PS Ratio too high?
ProQR Therapeutics NV's current Cyclically Adjusted PS Ratio of 13.23 is 37% below median its 10-year median of 20.97. Over the past 10 years, this metric has ranged from a low of 9.33 to a high of 57.50. The Biotechnology industry median Cyclically Adjusted PS Ratio is 5.65. ProQR Therapeutics NV's value of 13.23 is 134.2% above this industry median. Based on the distribution chart, ProQR Therapeutics NV ranks #391 out of 538 companies in the Biotechnology industry, which is below the industry midpoint. Overall, ProQR Therapeutics NV has a GF Scoreâ„¢ of 48/100 and is considered Modestly Undervalued, reflecting its overall financial health beyond just this single metric.
How does ProQR Therapeutics NV's Cyclically Adjusted PS Ratio compare to CRBP and NRXP?
According to the Biotechnology industry distribution chart, ProQR Therapeutics NV ranks #391 out of 538 companies for Cyclically Adjusted PS Ratio. This places ProQR Therapeutics NV in the lower half of its industry. The industry median Cyclically Adjusted PS Ratio is 5.65. ProQR Therapeutics NV's value of 13.23 is 134.2% above this benchmark. Historically, ProQR Therapeutics NV's own Cyclically Adjusted PS Ratio has ranged from 9.33 to 57.50 over the past decade. While the company's 10-year median is 20.97 vs. the industry median of 5.65, ProQR Therapeutics NV has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PS Ratio for a Biotechnology company?
The median Cyclically Adjusted PS Ratio among Biotechnology companies is 5.65, based on 538 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PS Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PS Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. ProQR Therapeutics NV's current Cyclically Adjusted PS Ratio of 13.23 is 134.2% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PS Ratio mean?
A high Cyclically Adjusted PS Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PS Ratio is the ratio of share price to a company's inflation-adjusted revenue per share over a 10-year period. View historical data on ProQR Therapeutics NV and its competitors. For the Biotechnology industry, the median Cyclically Adjusted PS Ratio is 5.65 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. ProQR Therapeutics NV's current Cyclically Adjusted PS Ratio is 13.23, which is 37% below median its own 10-year median of 20.97. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is ProQR Therapeutics NV stock overvalued right now?
Based on GuruFocus' analysis, ProQR Therapeutics NV (PRQR) is currently considered Modestly Undervalued. The stock's GF Value™ is $2.05, compared to a current price of $1.72 — trading 16.1% below its estimated fair value. The current Cyclically Adjusted PS Ratio is 13.23, which is 37% below median its 10-year median of 20.97 and 134.2% above the Biotechnology industry median of 5.65. ProQR Therapeutics NV's overall GF Score™ is 48/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PS Ratio calculated?
Cyclically Adjusted PS Ratio is calculated from a company's financial statements. For ProQR Therapeutics NV (PRQR), the current Cyclically Adjusted PS Ratio is 13.23 as of Jul. 25, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is ProQR Therapeutics NV (PRQR) Overvalued in 2026?
Based on GuruFocus' analysis, ProQR Therapeutics NV stock appears to be undervalued.
The current stock price of $1.72 is trading 16.1% below its estimated GF Value™ of $2.05.
GuruFocus considers ProQR Therapeutics NV to be Modestly Undervalued.
Key valuation signals for PRQR:
Cyclically Adjusted PS Ratio: 13.23 (37% below median its 10-year median of 20.97)
GF Value™: $2.05 vs. price of $1.72 (16.1% below fair value)
Industry Position: 134.2% above the Biotechnology median (#391 of 538)
No single metric tells the full story. See the PRQR stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
ProQR Therapeutics NV is a biopharmaceutical company. It discovers and develops RNA therapeutics for patients with severe genetic rare diseases such as cystic fibrosis, Leber congenital amaurosis type 10, and dystrophic epidermolysis bullosa. The only reportable segment of the company is the discovery and development of different, RNA-based therapeutics. Geographically, the company operates in United States.
48GF Score
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Cyclically Adjusted PS Ratio is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
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