PRQR (ProQR Therapeutics NV) EV-to-OCF: -3.00 (As of Jul. 25, 2026)

Author: Vera Yuan Vera Yuan
Vera Yuan
Vera Yuan
Director of Data and Quant Analytics at GuruFocus
Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Reviewed by: Charlie Tian Charlie Tian
Charlie Tian
Charlie Tian
Founder & CEO of GuruFocus
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.

PRQR ProQR Therapeutics NV PRQR
48 GF Score
Price $1.72
GF Value $2.05
Valuation Modestly Undervalued
! 4 Warning Signs
View Full Analysis

What is ProQR Therapeutics NV EV-to-OCF?

ProQR Therapeutics NV PRQR -3.91% 48 EV-to-OCF is -3.00 as of Jul. 25, 2026. GuruFocus rates PRQR with a GF Score™ of 48/100 and a GF Value™ of $2.05 (Modestly Undervalued). The stock has 4 warning signs investors should review. Among 1,410 Biotechnology companies, ProQR Therapeutics NV ranks worse than 50.85% on this metric.

EV-to-OCF is calculated as enterprise value divided by its cash flow from operations. As of today, ProQR Therapeutics NV's Enterprise Value is $168.38 Mil. ProQR Therapeutics NV's Cash Flow from Operations for the trailing twelve months (TTM) ended in Mar. 2026 was $-56.04 Mil. Therefore, ProQR Therapeutics NV's EV-to-OCF for today is -3.00.

The historical rank and industry rank for ProQR Therapeutics NV's EV-to-OCF or its related term are showing as below:

PRQR' s EV-to-OCF Range Over the Past 10 Years
Min: -31.35   Med: -1.77   Max: 10.49
Current: -3

During the past 13 years, the highest EV-to-OCF of ProQR Therapeutics NV was 10.49. The lowest was -31.35. And the median was -1.77.

PRQR's EV-to-OCF is ranked worse than
50.85% of 1410 companies
in the Biotechnology industry
Industry Median: -3.315 vs PRQR: -3.00

EV-to-OCF is a valuation multiple that allows analysts and investors to compare stocks, preferably in the same sector or industry. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.

As of today (2026-07-25), ProQR Therapeutics NV's stock price is $1.72. ProQR Therapeutics NV's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Mar. 2026 was $-0.499. Therefore, ProQR Therapeutics NV's PE Ratio (TTM) for today is At Loss.


ProQR Therapeutics NV  (NAS:PRQR) EV-to-OCF Explanation

EV-to-OCF is a valuation multiple that allows analysts and investors to compare stocks, preferably in the same sector or industry. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.

ProQR Therapeutics NV's PE Ratio (TTM) for today is calculated as:

PE Ratio (TTM)=Share Price (Today)/Earnings per Share (Diluted) (TTM)
=1.72/-0.499
=At Loss

ProQR Therapeutics NV's share price for today is $1.72.
ProQR Therapeutics NV's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-0.499.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Enterprise Value is used because it is a more complete measure in reflecting how much an investor pays when buying a company. Cash Flow from Operations is an important financial metric because it represents the cash generated from operating activities at a company's disposal. Companies with a low EV-to-OCF ratio, combined with a strong balance sheet are generally considered as undervalued.


ProQR Therapeutics NV EV-to-OCF Related Terms


ProQR Therapeutics NV EV-to-OCF Historical Data

* Premium members only.

The historical data trend for ProQR Therapeutics NV's EV-to-OCF can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

ProQR Therapeutics NV EV-to-OCF Chart

ProQR Therapeutics NV Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
EV-to-OCF
Get a 7-Day Free Trial Premium Member Only Premium Member Only -14.52 -3.05 2.25 -3.68 -1.99

ProQR Therapeutics NV Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
EV-to-OCF Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -0.38 -2.08 -2.18 -1.99 -1.70

PRQR vs CRBP, NRXP, CRBU: EV-to-OCF Comparison

For the Biotechnology subindustry, ProQR Therapeutics NV's EV-to-OCF, along with its competitors' market caps and EV-to-OCF data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


ProQR Therapeutics NV EV-to-OCF vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, ProQR Therapeutics NV's EV-to-OCF distribution charts can be found below:

* The bar in red indicates where ProQR Therapeutics NV's EV-to-OCF falls into.


PRQR
48GF Score
ProQR Therapeutics NV PRQR
EV-to-OCF is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

ProQR Therapeutics NV EV-to-OCF Calculation

ProQR Therapeutics NV's EV-to-OCF for today is calculated as:

EV-to-OCF=Enterprise Value (Today)/Cash Flow from Operations (TTM)
=168.379/-56.035
=-3.00

ProQR Therapeutics NV's current Enterprise Value is $168.38 Mil.
ProQR Therapeutics NV's Cash Flow from Operations for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-56.04 Mil.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about EV-to-OCF →
What does a EV-to-OCF of -3.00 mean?
ProQR Therapeutics NV (PRQR) has a EV-to-OCF of -3.00 as of Jul. 25, 2026. According to the industry distribution chart, ProQR Therapeutics NV ranks #717 out of 1410 companies in the Biotechnology industry, placing it in the top 50.9%.
Is ProQR Therapeutics NV's EV-to-OCF too high?
ProQR Therapeutics NV's current EV-to-OCF is -3.00. Based on the distribution chart, ProQR Therapeutics NV ranks #717 out of 1410 companies in the Biotechnology industry, which is below the industry midpoint. Overall, ProQR Therapeutics NV has a GF Score™ of 48/100 and is considered Modestly Undervalued, reflecting its overall financial health beyond just this single metric.
How does ProQR Therapeutics NV's EV-to-OCF compare to CRBP and NRXP?
According to the Biotechnology industry distribution chart, ProQR Therapeutics NV ranks #717 out of 1410 companies for EV-to-OCF. This places ProQR Therapeutics NV in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-OCF for a Biotechnology company?
A good EV-to-OCF depends on the Biotechnology industry context. However, EV-to-OCF should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-OCF mean?
A high EV-to-OCF can signal that a stock is expensive relative to its fundamentals. ProQR Therapeutics NV's current EV-to-OCF is -3.00. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is ProQR Therapeutics NV stock overvalued right now?
Based on GuruFocus' analysis, ProQR Therapeutics NV (PRQR) is currently considered Modestly Undervalued. The stock's GF Value™ is $2.05, compared to a current price of $1.72 — trading 16.1% below its estimated fair value. The current EV-to-OCF is -3.00. ProQR Therapeutics NV's overall GF Score™ is 48/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-OCF calculated?
EV-to-OCF is calculated from a company's financial statements. For ProQR Therapeutics NV (PRQR), the current EV-to-OCF is -3.00 as of Jul. 25, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is ProQR Therapeutics NV (PRQR) Overvalued in 2026?

Based on GuruFocus' analysis, ProQR Therapeutics NV stock appears to be undervalued. The current stock price of $1.72 is trading 16.1% below its estimated GF Value™ of $2.05. GuruFocus considers ProQR Therapeutics NV to be Modestly Undervalued.

Key valuation signals for PRQR:

  • EV-to-OCF: -3.00
  • GF Value™: $2.05 vs. price of $1.72 (16.1% below fair value)
  • GF Score™: 48/100 with 4 warning signs

No single metric tells the full story. See the PRQR stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


ProQR Therapeutics NV Business Description

Other Exchanges 0PQ:Germany
Address Zernikedreef 9, Leiden, ZH, NLD, 2333 CK
ProQR Therapeutics NV is a biopharmaceutical company. It discovers and develops RNA therapeutics for patients with severe genetic rare diseases such as cystic fibrosis, Leber congenital amaurosis type 10, and dystrophic epidermolysis bullosa. The only reportable segment of the company is the discovery and development of different, RNA-based therapeutics. Geographically, the company operates in United States.
48GF Score

Get the complete analysis for PRQR

EV-to-OCF is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$1.72
Price
$2.05
GF Value