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Assembly BiosciencesASMB +0.83%32 Degree of Operating Leverage is -0.58 as of Mar. 2026. GuruFocus rates ASMB with a GF Score™ of 32/100. The stock has 3 warning signs investors should review. Among 851 Biotechnology companies, Assembly Biosciences ranks better than 64.28% on this metric.
Degree of Operating Leverage (DOL) measures the percentage change in EBIT for a unit change in Revenue.
Assembly Biosciences's Degree of Operating Leverage for the quarter that ended in Mar. 2026 was -0.58. The higher Degree of Operating Leverage, the higher operating risk the company will take.
The industry rank for Assembly Biosciences's Degree of Operating Leverage or its related term are showing as below:
ASMB's Degree of Operating Leverage is ranked better than 64.28% of 851
companies
in the Biotechnology industry
Industry Median: -0.03
vs ASMB: -0.58
Assembly Biosciences (NAS:ASMB) Degree of Operating Leverage Explanation
Degree of Operating Leverage (DOL) is a leverage ratio that measures the sensitivity of a company’s operting income, also referred to as Earnings Before Interest and Taxes (EBIT), to fluctuations in its Revenue. DOL is a method used to quantify a company’s operating risk. This risk is related to the company's structure of variable costs and fixed costs. Since the fixed costs do not allow the company to adjust the operating costs, the operating risk rises with a higher fixed-to-variable costs proportion.
A high Degree of Operating Leverage indicates that the company’s fixed costs exceed its variable costs. By increasing the sales, the company can earn more profits. In addition, the company must be able to maintain relatively high sales to cover all fixed costs.
Be Aware
The use of operating leverage varies across different industries and business sectors, and the application of Degree of Operating Leverage (DOL) should be adjusted accordingly.
Assembly Biosciences Degree of Operating Leverage Related Terms
Assembly Biosciences Degree of Operating Leverage Historical Data
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The historical data trend for Assembly Biosciences's Degree of Operating Leverage can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Assembly Biosciences Degree of Operating Leverage Chart
ASMB vs ZURA, ARVN, ARTV: Degree of Operating Leverage Comparison
For the Biotechnology subindustry, Assembly Biosciences's Degree of Operating Leverage, along with its competitors' market caps and Degree of Operating Leverage data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Assembly Biosciences Degree of Operating Leverage vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Assembly Biosciences's Degree of Operating Leverage distribution charts can be found below:
* The bar in red indicates where Assembly Biosciences's Degree of Operating Leverage falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
** TTM data of EBIT and Revenue was used to calculate Degree of Operating Leverage.
*** Please be aware that the Degree of Operating Leverage calculations are based on company-level data using the primary share class. The calculated data provided is for demonstration purposes and may slightly differ from the results displayed in the title due to potential variations caused by currency exchange rate differences throughout the year.
What does a Degree of Operating Leverage of -0.58 mean?
Assembly Biosciences (ASMB) has a Degree of Operating Leverage of -0.58 as of Mar. 2026. Degree of Operating Leverage (DOL) measures the percentage change in EBIT for a unit change in Revenue. View historical data for Assembly Biosciences and its competitors. According to the industry distribution chart, Assembly Biosciences ranks #304 out of 851 companies in the Biotechnology industry, placing it in the top 35.7%.
Is Assembly Biosciences' Degree of Operating Leverage too high?
Assembly Biosciences' current Degree of Operating Leverage is -0.58. Based on the distribution chart, Assembly Biosciences ranks #304 out of 851 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Assembly Biosciences has a GF Score™ of 32/100, reflecting its overall financial health beyond just this single metric.
How does Assembly Biosciences' Degree of Operating Leverage compare to ZURA and ARVN?
According to the Biotechnology industry distribution chart, Assembly Biosciences ranks #304 out of 851 companies for Degree of Operating Leverage. This puts Assembly Biosciences in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Degree of Operating Leverage for a Biotechnology company?
A good Degree of Operating Leverage depends on the Biotechnology industry context. However, Degree of Operating Leverage should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Degree of Operating Leverage mean?
A high Degree of Operating Leverage can signal that a stock is expensive relative to its fundamentals. Degree of Operating Leverage (DOL) measures the percentage change in EBIT for a unit change in Revenue. View historical data for Assembly Biosciences and its competitors. Assembly Biosciences's current Degree of Operating Leverage is -0.58. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Assembly Biosciences stock overvalued right now?
Assembly Biosciences (ASMB) has a current Degree of Operating Leverage of -0.58. The current Degree of Operating Leverage is -0.58. Assembly Biosciences' overall GF Score™ is 32/100 with 3 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Degree of Operating Leverage calculated?
Degree of Operating Leverage is calculated from a company's financial statements. For Assembly Biosciences (ASMB), the current Degree of Operating Leverage is -0.58 as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Assembly Biosciences Inc is a clinical-stage biotechnology company. The Company's pipeline includes multiple clinical-stage investigational therapies, including: (1) two long-acting helicase-primase inhibitors (HPI) for the treatment of recurrent genital herpes; (2) an orally bioavailable hepatitis delta virus entry inhibitor; and (3) a potent next-generation capsid assembly modulator designed to disrupt the replication cycle of hepatitis B virus (HBV) at several key points. The Company's pipeline also includes a novel, oral broad-spectrum non-nucleoside polymerase inhibitor (NNPI) for the treatment of transplant-related herpesviruses.
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