Illumina (MIL:1ILMN) E10: €-0.23 (As of Mar. 2026)


MIL:1ILMN Illumina Inc MIL:1ILMN
49 GF Score
Price €143.82
GF Value €104.58
Valuation Significantly Overvalued
! 7 Warning Signs
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What is Illumina E10?

Illumina MIL:1ILMN 49 E10 is €-0.23 as of Mar. 2026. GuruFocus rates MIL:1ILMN with a GF Score™ of 49/100 and a GF Value™ of €104.58 (Significantly Overvalued). The stock has 7 warning signs investors should review.

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller P/E calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years.

Illumina's adjusted earnings per share data for the three months ended in Mar. 2026 was €0.753. Add all the adjusted EPS for the past 10 years together and divide 10 will get our e10, which is €-0.23 for the trailing ten years ended in Mar. 2026.

Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the E10 growth rate using E10 data.

During the past 13 years, the highest 3-Year average E10 Growth Rate of Illumina was 234.70% per year. The lowest was -41.90% per year. And the median was 44.20% per year.

As of today (2026-06-26), Illumina's current stock price is €143.82. Illumina's E10 for the quarter that ended in Mar. 2026 was €-0.23. Illumina's Shiller PE Ratio of today is .

During the past 13 years, the highest Shiller PE Ratio of Illumina was 221.74. The lowest was 42.24. And the median was 118.30.


Illumina  (MIL:1ILMN) E10 Explanation

If a company grows much fast than inflation, E10 may underestimate the company's earnings power. Shiller PE Ratio can seem to be too high even the actual P/E is low.

For the Shiller P/E, the earnings of the past 10 years are inflation-adjusted and averaged. The result is used for P/E calculation. Since it looks at the average over the last 10 years, the Shiller P/E is also called PE10.

The Shiller P/E was first used by professor Robert Shiller to measure the valuation of the overall market. The same calculation is applied here to individual companies.

During the past 13 years, the highest Shiller P/E Ratio of Illumina was 221.74. The lowest was 42.24. And the median was 118.30.


Be Aware

Shiller PE Ratio works better for cyclical companies. It gives you a better idea on the company's real earnings power.


Illumina E10 Related Terms


Illumina E10 Historical Data

* Premium members only.

The historical data trend for Illumina's E10 can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Illumina E10 Chart

Illumina Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
E10
Get a 7-Day Free Trial Premium Member Only Premium Member Only 0.00 0.00 0.61 -0.38 -0.24

Illumina Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
E10 Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -0.40 -0.33 -0.36 -0.24 -0.23

MIL:1ILMN vs MTD, DGX, LH: E10 Comparison

For the Diagnostics & Research subindustry, Illumina's Shiller PE Ratio, along with its competitors' market caps and Shiller PE Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Illumina Shiller PE Ratio vs Medical Diagnostics & Research Industry

For the Medical Diagnostics & Research industry and Healthcare sector, Illumina's Shiller PE Ratio distribution charts can be found below:

* The bar in red indicates where Illumina's Shiller PE Ratio falls into.


MIL:1ILMN
49GF Score
Illumina Inc MIL:1ILMN
E10 is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Illumina E10 Calculation

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller P/E calculation. When we calculate the today's Shiller P/E ratio of a stock, we use today's price divided by E10.

What is E10? How do we calculate E10?

E10 is the average of the inflation adjusted earnings of a company over the past 10 years. Let's use an example to explain.

If we want to calculate the E10 of Wal-Mart (WMT) for Dec. 31, 2010, we need to have the inflation data and the earnings from 2001 through 2010.

We adjusted the earnings of 2001 earnings data with the total inflation from 2001 through 2010 to the equivalent earnings in 2010. If the total inflation from 2001 to 2010 is 40%, and Wal-Mart earned $1 a share in 2001, then the 2001's equivalent earnings in 2010 is $1.4 a share. If Wal-Mart earns $1 again in 2002, and the total inflation from 2002 through 2010 is 35%, then the equivalent 2002 earnings in 2010 is $1.35. So on and so forth, you get the equivalent earnings of past 10 years. Then you add them together and divided the sum by 10 to get E10.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

For example, Illumina's adjusted earnings per share data for the three months ended in Mar. 2026 was:

Adj_EPS= Earnings per Share (Diluted) /CPI of Mar. 2026 (Change)*Current CPI (Mar. 2026)
=0.753/330.2130*330.2130
=0.753

Current CPI (Mar. 2026) = 330.2130.

Illumina Quarterly Data

per share eps CPI Adj_EPS
201606 0.730 241.018 1.000
201609 0.775 241.428 1.060
201612 0.796 241.432 1.089
201703 2.319 243.801 3.141
201706 0.774 244.955 1.043
201709 0.931 246.819 1.246
201712 0.389 246.524 0.521
201803 1.144 249.554 1.514
201806 1.207 251.989 1.582
201809 1.140 252.439 1.491
201812 1.239 251.233 1.629
201903 1.389 254.202 1.804
201906 1.761 256.143 2.270
201909 1.435 256.759 1.846
201912 1.449 256.974 1.862
202003 1.059 258.115 1.355
202006 0.284 257.797 0.364
202009 1.027 260.280 1.303
202012 1.438 260.474 1.823
202103 0.840 264.877 1.047
202106 1.046 271.696 1.271
202109 1.768 274.310 2.128
202112 0.628 278.802 0.744
202203 0.499 287.504 0.573
202206 -3.216 296.311 -3.584
202209 -24.503 296.808 -27.261
202212 -0.840 296.797 -0.935
202303 0.019 301.836 0.021
202306 -1.366 305.109 -1.478
202309 -4.469 307.789 -4.795
202312 -1.018 306.746 -1.096
202403 -0.727 312.332 -0.769
202406 -11.594 314.175 -12.186
202409 3.982 315.301 4.170
202412 1.117 315.605 1.169
202503 0.758 319.799 0.783
202506 1.292 322.561 1.323
202509 0.835 324.800 0.849
202512 1.845 324.054 1.880
202603 0.753 330.213 0.753

Add all the adjusted EPS together and divide 10 will get our e10.

Frequently Asked Questions Learn more about E10 →
What does a E10 of €-0.23 mean?
Illumina (MIL:1ILMN) has a E10 of €-0.23 as of Mar. 2026. E10 represents the company's inflation-adjusted earnings per share over a 10-year period. View historical data on Illumina and its competitors.
Is Illumina's E10 too high?
Illumina's current E10 is €-0.23. Overall, Illumina has a GF Score™ of 49/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Illumina's E10 compare to MTD and DGX?
Illumina's E10 of €-0.23 can be compared against companies in the Medical Diagnostics & Research industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good E10 for a Medical Diagnostics & Research company?
A good E10 depends on the Medical Diagnostics & Research industry context. However, E10 should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high E10 mean?
A high E10 can signal that a stock is expensive relative to its fundamentals. E10 represents the company's inflation-adjusted earnings per share over a 10-year period. View historical data on Illumina and its competitors. Illumina's current E10 is €-0.23. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Illumina stock overvalued right now?
Based on GuruFocus' analysis, Illumina (MIL:1ILMN) is currently considered Significantly Overvalued. The stock's GF Value™ is €104.58, compared to a current price of €143.82 — trading 37.5% above its estimated fair value. The current E10 is €-0.23. Illumina's overall GF Score™ is 49/100 with 7 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is E10 calculated?
E10 is calculated from a company's financial statements. For Illumina (MIL:1ILMN), the current E10 is €-0.23 as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Illumina (MIL:1ILMN) Overvalued in 2026?

Based on GuruFocus' analysis, Illumina stock appears to be overvalued. The current stock price of €143.82 is trading 37.5% above its estimated GF Value™ of €104.58. GuruFocus considers Illumina to be Significantly Overvalued.

Key valuation signals for MIL:1ILMN:

  • E10: €-0.23
  • GF Value™: €104.58 vs. price of €143.82 (37.5% above fair value)
  • GF Score™: 49/100 with 7 warning signs

No single metric tells the full story. See the MIL:1ILMN stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Illumina Business Description

Address 5200 Illumina Way, San Diego, CA, USA, 92122
Illumina provides tools and services to analyze genetic material with life science and clinical lab applications. The company generates over 90% of its revenue from sequencing instruments, consumables, and services. Illumina's high-throughput technology enables whole genome sequencing in humans and other large organisms. Its lower throughput tools enable applications that require smaller data outputs, such as viral and cancer tumor screening. Illumina also sells microarrays (9% of 2024 sales) that enable lower-cost, focused genetic screening with primarily consumer and agricultural applications.
49GF Score

Get the complete analysis for MIL:1ILMN

E10 is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

€143.82
Price
€104.58
GF Value