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Appili TherapeuticsAPLIF EV-to-EBITDA is -6.28 as of Jul. 19, 2026. The stock has 2 warning signs investors should review. Among 398 Biotechnology companies, Appili Therapeutics ranks worse than 251256.03% on this metric.
EV-to-EBITDA is calculated as enterprise value divided by its EBITDA. As of today, Appili Therapeutics's enterprise value is $10.48 Mil.
Appili Therapeutics's EBITDA for the trailing twelve months (TTM) ended in Mar. 2026 was $-1.67 Mil. Therefore, Appili Therapeutics's EV-to-EBITDA for today is -6.28.
The historical rank and industry rank for Appili Therapeutics's EV-to-EBITDA or its related term are showing as below:
APLIF'
s EV-to-EBITDA Range Over the Past 10 Years
Min: -758.46 Med: -4.11 Max: 42.41
Current: -6.48
During the past 9 years, the highest EV-to-EBITDA of Appili Therapeutics was 42.41. The lowest was -758.46. And the median was -4.11.
APLIF's EV-to-EBITDA is ranked worse than 100% of 398
companies
in the Biotechnology industry
Industry Median: 12.205
vs APLIF: -6.48
EV-to-EBITDA is a valuation multiple used in finance and investment to measure the value of a company. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio to determine the fair market value of a company.
EV-to-EBITDA is a valuation multiple used in finance and investment to measure the value of a company. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.
Appili Therapeutics's PE Ratio (TTM) for today is calculated as:
Appili Therapeutics's share price for today is $0.01015.
Appili Therapeutics's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-0.028.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Study has found that the companies with the lowest EV-to-EBITDA outperforms companies measured as cheap by other ratios such as PE Ratio (TTM).
The historical data trend for Appili Therapeutics's EV-to-EBITDA can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
APLIF vs VRTX, REGN, ALNY: EV-to-EBITDA Comparison
For the Biotechnology subindustry, Appili Therapeutics's EV-to-EBITDA, along with its competitors' market caps and EV-to-EBITDA data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Appili Therapeutics EV-to-EBITDA vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Appili Therapeutics's EV-to-EBITDA distribution charts can be found below:
* The bar in red indicates where Appili Therapeutics's EV-to-EBITDA falls into.
Appili Therapeutics's current Enterprise Value is $10.48 Mil.
Appili Therapeutics's EBITDA for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-1.67 Mil.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Appili Therapeutics (APLIF) has a EV-to-EBITDA of -6.28 as of Jul. 19, 2026. EV to EBITDA ratio is the company's enterprise value divided by earnings before interest, taxes, depreciation and amortization. View historical data on Appili Therapeutics. According to the industry distribution chart, Appili Therapeutics ranks #999999 out of 398 companies in the Biotechnology industry.
Is Appili Therapeutics' EV-to-EBITDA too high?
Appili Therapeutics' current EV-to-EBITDA is -6.28. Based on the distribution chart, Appili Therapeutics ranks #999999 out of 398 companies in the Biotechnology industry, which is in the bottom quartile relative to peers.
How does Appili Therapeutics' EV-to-EBITDA compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Appili Therapeutics ranks #999999 out of 398 companies for EV-to-EBITDA. This places Appili Therapeutics in the lower half of its industry. The industry median EV-to-EBITDA is 12.21. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-EBITDA for a Biotechnology company?
The median EV-to-EBITDA among Biotechnology companies is 12.21, based on 398 companies in the industry. Companies in the top quartile (top 25%) have a EV-to-EBITDA significantly above this median, while those in the bottom quartile fall well below. However, EV-to-EBITDA should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-EBITDA mean?
A high EV-to-EBITDA can signal that a stock is expensive relative to its fundamentals. EV to EBITDA ratio is the company's enterprise value divided by earnings before interest, taxes, depreciation and amortization. View historical data on Appili Therapeutics. For the Biotechnology industry, the median EV-to-EBITDA is 12.21 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Appili Therapeutics's current EV-to-EBITDA is -6.28. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Appili Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Appili Therapeutics (APLIF) is currently considered Fairly Valued. The stock's GF Value™ is $0.01, compared to a current price of $0.01 — trading 1.5% above its estimated fair value. The current EV-to-EBITDA is -6.28. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-EBITDA calculated?
EV-to-EBITDA is calculated from a company's financial statements. For Appili Therapeutics (APLIF), the current EV-to-EBITDA is -6.28 as of Jul. 19, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Appili Therapeutics Inc is a biopharmaceutical company. The company is engaged in novel antibiotic and anti-infective therapies to help patients suffering from serious infections. Its anti-infective portfolio currently includes programs namely ATI-1701, ATI-1801.
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