Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.
Appili TherapeuticsAPLIF EV-to-OCF is -10.47 as of Aug. 11, 2026. The stock has 2 warning signs investors should review. Among 1,405 Biotechnology companies, Appili Therapeutics ranks better than 70.82% on this metric.
EV-to-OCF is calculated as enterprise value divided by its cash flow from operations. As of today, Appili Therapeutics's Enterprise Value is $10.15 Mil.
Appili Therapeutics's Cash Flow from Operations for the trailing twelve months (TTM) ended in Mar. 2026 was $-0.97 Mil. Therefore, Appili Therapeutics's EV-to-OCF for today is -10.47.
The historical rank and industry rank for Appili Therapeutics's EV-to-OCF or its related term are showing as below:
APLIF'
s EV-to-OCF Range Over the Past 10 Years
Min: -1405.2 Med: -3.99 Max: 200.1
Current: -10.64
During the past 9 years, the highest EV-to-OCF of Appili Therapeutics was 200.10. The lowest was -1405.20. And the median was -3.99.
APLIF's EV-to-OCF is ranked better than 70.82% of 1405
companies
in the Biotechnology industry
Industry Median: -3.45
vs APLIF: -10.64
EV-to-OCF is a valuation multiple that allows analysts and investors to compare stocks, preferably in the same sector or industry. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.
EV-to-OCF is a valuation multiple that allows analysts and investors to compare stocks, preferably in the same sector or industry. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.
Appili Therapeutics's PE Ratio (TTM) for today is calculated as:
Appili Therapeutics's share price for today is $0.0078.
Appili Therapeutics's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-0.028.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Enterprise Value is used because it is a more complete measure in reflecting how much an investor pays when buying a company. Cash Flow from Operations is an important financial metric because it represents the cash generated from operating activities at a company's disposal. Companies with a low EV-to-OCF ratio, combined with a strong balance sheet are generally considered as undervalued.
Appili Therapeutics EV-to-OCF Related Terms
Appili Therapeutics EV-to-OCF Historical Data
* Premium members only.
The historical data trend for Appili Therapeutics's EV-to-OCF can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
For the Biotechnology subindustry, Appili Therapeutics's EV-to-OCF, along with its competitors' market caps and EV-to-OCF data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Appili Therapeutics EV-to-OCF vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Appili Therapeutics's EV-to-OCF distribution charts can be found below:
* The bar in red indicates where Appili Therapeutics's EV-to-OCF falls into.
Appili Therapeutics's current Enterprise Value is $10.15 Mil.
Appili Therapeutics's Cash Flow from Operations for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-0.97 Mil.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Appili Therapeutics (APLIF) has a EV-to-OCF of -10.47 as of Aug. 11, 2026. According to the industry distribution chart, Appili Therapeutics ranks #410 out of 1405 companies in the Biotechnology industry, placing it in the top 29.2%.
Is Appili Therapeutics' EV-to-OCF too high?
Appili Therapeutics' current EV-to-OCF is -10.47. Based on the distribution chart, Appili Therapeutics ranks #410 out of 1405 companies in the Biotechnology industry, which is above the industry midpoint.
How does Appili Therapeutics' EV-to-OCF compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Appili Therapeutics ranks #410 out of 1405 companies for EV-to-OCF. This puts Appili Therapeutics in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-OCF for a Biotechnology company?
A good EV-to-OCF depends on the Biotechnology industry context. However, EV-to-OCF should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-OCF mean?
A high EV-to-OCF can signal that a stock is expensive relative to its fundamentals. Appili Therapeutics's current EV-to-OCF is -10.47. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Appili Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Appili Therapeutics (APLIF) is currently considered Modestly Undervalued. The stock's GF Value™ is $0.01, compared to a current price of $0.01 — trading 22% below its estimated fair value. The current EV-to-OCF is -10.47. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-OCF calculated?
EV-to-OCF is calculated from a company's financial statements. For Appili Therapeutics (APLIF), the current EV-to-OCF is -10.47 as of Aug. 11, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Appili Therapeutics Inc is a biopharmaceutical company. The company is engaged in novel antibiotic and anti-infective therapies to help patients suffering from serious infections. Its anti-infective portfolio currently includes programs namely ATI-1701, ATI-1801.
Quick Browse
Personalize
Premium Gurus 
Create New Portfolio
APLIF has been successfully added to your 
