Heron Therapeutics (FRA:AXD2) EV-to-EBITDA: -11.93 (As of Jul. 21, 2026)

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FRA:AXD2 Heron Therapeutics Inc FRA:AXD2
47 GF Score
Price €0.41
GF Value €1.29
Valuation Possible Value Trap
! 4 Warning Signs
View Full Analysis

What is Heron Therapeutics EV-to-EBITDA?

Heron Therapeutics FRA:AXD2 -1.07% 47 EV-to-EBITDA is -11.93 as of Jul. 21, 2026. GuruFocus rates FRA:AXD2 with a GF Score™ of 47/100 and a GF Value™ of €1.29 (Possible Value Trap). The stock has 4 warning signs investors should review. Among 400 Biotechnology companies, Heron Therapeutics ranks worse than 249999.75% on this metric.

EV-to-EBITDA is calculated as enterprise value divided by its EBITDA. As of today, Heron Therapeutics's enterprise value is €165.8 Mil. Heron Therapeutics's EBITDA for the trailing twelve months (TTM) ended in Mar. 2026 was €-13.9 Mil. Therefore, Heron Therapeutics's EV-to-EBITDA for today is -11.93.

The historical rank and industry rank for Heron Therapeutics's EV-to-EBITDA or its related term are showing as below:

FRA:AXD2' s EV-to-EBITDA Range Over the Past 10 Years
Min: -98.26   Med: -5.4   Max: 210.83
Current: -11.65

During the past 13 years, the highest EV-to-EBITDA of Heron Therapeutics was 210.83. The lowest was -98.26. And the median was -5.40.

FRA:AXD2's EV-to-EBITDA is ranked worse than
100% of 400 companies
in the Biotechnology industry
Industry Median: 11.905 vs FRA:AXD2: -11.65

EV-to-EBITDA is a valuation multiple used in finance and investment to measure the value of a company. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio to determine the fair market value of a company.

As of today (2026-07-21), Heron Therapeutics's stock price is €0.4074. Heron Therapeutics's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Mar. 2026 was €-0.154. Therefore, Heron Therapeutics's PE Ratio (TTM) for today is At Loss.

The "classic" EV-to-EBITDA is much better in capturing debt and net cash than the PE Ratio (TTM).


Heron Therapeutics  (FRA:AXD2) EV-to-EBITDA Explanation

EV-to-EBITDA is a valuation multiple used in finance and investment to measure the value of a company. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.

Heron Therapeutics's PE Ratio (TTM) for today is calculated as:

PE Ratio (TTM)=Share Price (Today)/Earnings per Share (Diluted) (TTM)
=0.4074/-0.154
=At Loss

Heron Therapeutics's share price for today is €0.4074.
Heron Therapeutics's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was €-0.154.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Study has found that the companies with the lowest EV-to-EBITDA outperforms companies measured as cheap by other ratios such as PE Ratio (TTM).

Please read Which price ratio outperforms the enterprise multiple?


Heron Therapeutics EV-to-EBITDA Related Terms


Heron Therapeutics EV-to-EBITDA Historical Data

* Premium members only.

The historical data trend for Heron Therapeutics's EV-to-EBITDA can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Heron Therapeutics EV-to-EBITDA Chart

Heron Therapeutics Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
EV-to-EBITDA
Get a 7-Day Free Trial Premium Member Only Premium Member Only -4.34 -2.10 -3.42 -69.47 -41.07

Heron Therapeutics Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
EV-to-EBITDA Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 167.48 60.16 40.81 -41.07 -15.34

FRA:AXD2 vs ENTX, OKYO, EDSA: EV-to-EBITDA Comparison

For the Biotechnology subindustry, Heron Therapeutics's EV-to-EBITDA, along with its competitors' market caps and EV-to-EBITDA data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Heron Therapeutics EV-to-EBITDA vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Heron Therapeutics's EV-to-EBITDA distribution charts can be found below:

* The bar in red indicates where Heron Therapeutics's EV-to-EBITDA falls into.


FRA:AXD2
47GF Score
Heron Therapeutics Inc FRA:AXD2
EV-to-EBITDA is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Heron Therapeutics EV-to-EBITDA Calculation

Heron Therapeutics's EV-to-EBITDA for today is calculated as:

EV-to-EBITDA=Enterprise Value (Today)/EBITDA (TTM)
=165.815/-13.902
=-11.93

Heron Therapeutics's current Enterprise Value is €165.8 Mil.
Heron Therapeutics's EBITDA for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was €-13.9 Mil.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about EV-to-EBITDA →
What does a EV-to-EBITDA of -11.93 mean?
Heron Therapeutics (FRA:AXD2) has a EV-to-EBITDA of -11.93 as of Jul. 21, 2026. EV to EBITDA ratio is the company's enterprise value divided by earnings before interest, taxes, depreciation and amortization. View historical data on Heron Therapeutics. According to the industry distribution chart, Heron Therapeutics ranks #999999 out of 400 companies in the Biotechnology industry.
Is Heron Therapeutics' EV-to-EBITDA too high?
Heron Therapeutics' current EV-to-EBITDA is -11.93. Based on the distribution chart, Heron Therapeutics ranks #999999 out of 400 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Heron Therapeutics has a GF Score™ of 47/100 and is considered Possible Value Trap, reflecting its overall financial health beyond just this single metric.
How does Heron Therapeutics' EV-to-EBITDA compare to ENTX and OKYO?
According to the Biotechnology industry distribution chart, Heron Therapeutics ranks #999999 out of 400 companies for EV-to-EBITDA. This places Heron Therapeutics in the lower half of its industry. The industry median EV-to-EBITDA is 11.91. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-EBITDA for a Biotechnology company?
The median EV-to-EBITDA among Biotechnology companies is 11.91, based on 400 companies in the industry. Companies in the top quartile (top 25%) have a EV-to-EBITDA significantly above this median, while those in the bottom quartile fall well below. However, EV-to-EBITDA should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-EBITDA mean?
A high EV-to-EBITDA can signal that a stock is expensive relative to its fundamentals. EV to EBITDA ratio is the company's enterprise value divided by earnings before interest, taxes, depreciation and amortization. View historical data on Heron Therapeutics. For the Biotechnology industry, the median EV-to-EBITDA is 11.91 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Heron Therapeutics's current EV-to-EBITDA is -11.93. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Heron Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Heron Therapeutics (FRA:AXD2) is currently considered Possible Value Trap. The stock's GF Value™ is €1.29, compared to a current price of €0.41 — trading 68.4% below its estimated fair value. The current EV-to-EBITDA is -11.93. Heron Therapeutics' overall GF Score™ is 47/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-EBITDA calculated?
EV-to-EBITDA is calculated from a company's financial statements. For Heron Therapeutics (FRA:AXD2), the current EV-to-EBITDA is -11.93 as of Jul. 21, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Heron Therapeutics (FRA:AXD2) Overvalued in 2026?

Based on GuruFocus' analysis, Heron Therapeutics stock appears to be undervalued. The current stock price of €0.41 is trading 68.4% below its estimated GF Value™ of €1.29. GuruFocus considers Heron Therapeutics to be Possible Value Trap.

Key valuation signals for FRA:AXD2:

  • EV-to-EBITDA: -11.93
  • GF Value™: €1.29 vs. price of €0.41 (68.4% below fair value)
  • GF Score™: 47/100 with 4 warning signs

No single metric tells the full story. See the FRA:AXD2 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Heron Therapeutics Business Description

Other Exchanges HRTX:USA0J4V:UKAXD2:Germany
Address 100 Regency Forect Drive, Suite 300, Cary, NC, USA, 27518
Heron Therapeutics Inc is a commercial-stage biotechnology company. The company is focused on improving the lives of patients by developing treatments and commercializing therapeutic solutions to address some of the unmet patient needs. The company's product portfolio consists of APONVIE, SUSTOL, ZYNRELEF, and CINVANTI.
47GF Score

Get the complete analysis for FRA:AXD2

EV-to-EBITDA is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

€0.41
Price
€1.29
GF Value