Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.
PersonalisPSNL +0.36%58 EV-to-OCF is -14.24 as of Aug. 18, 2026. GuruFocus rates PSNL with a GF Score™ of 58/100 and a GF Value™ of $2.45 (Significantly Overvalued). The stock has 9 warning signs investors should review. Among 212 Medical Diagnostics & Research companies, Personalis ranks better than 83.96% on this metric.
EV-to-OCF is calculated as enterprise value divided by its cash flow from operations. As of today, Personalis's Enterprise Value is $1,314.13 Mil.
Personalis's Cash Flow from Operations for the trailing twelve months (TTM) ended in Jun. 2026 was $-92.30 Mil. Therefore, Personalis's EV-to-OCF for today is -14.24.
The historical rank and industry rank for Personalis's EV-to-OCF or its related term are showing as below:
PSNL'
s EV-to-OCF Range Over the Past 10 Years
Min: -39.27 Med: -5.19 Max: 172.47
Current: -14.24
During the past 9 years, the highest EV-to-OCF of Personalis was 172.47. The lowest was -39.27. And the median was -5.19.
PSNL's EV-to-OCF is ranked better than 83.96% of 212
companies
in the Medical Diagnostics & Research industry
Industry Median: 6.235
vs PSNL: -14.24
EV-to-OCF is a valuation multiple that allows analysts and investors to compare stocks, preferably in the same sector or industry. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.
EV-to-OCF is a valuation multiple that allows analysts and investors to compare stocks, preferably in the same sector or industry. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.
Personalis's share price for today is $13.94.
Personalis's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Jun. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-1.090.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Enterprise Value is used because it is a more complete measure in reflecting how much an investor pays when buying a company. Cash Flow from Operations is an important financial metric because it represents the cash generated from operating activities at a company's disposal. Companies with a low EV-to-OCF ratio, combined with a strong balance sheet are generally considered as undervalued.
Personalis EV-to-OCF Related Terms
Personalis EV-to-OCF Historical Data
* Premium members only.
The historical data trend for Personalis's EV-to-OCF can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
For the Diagnostics & Research subindustry, Personalis's EV-to-OCF, along with its competitors' market caps and EV-to-OCF data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Personalis EV-to-OCF vs Medical Diagnostics & Research Industry
For the Medical Diagnostics & Research industry and Healthcare sector, Personalis's EV-to-OCF distribution charts can be found below:
* The bar in red indicates where Personalis's EV-to-OCF falls into.
Personalis's current Enterprise Value is $1,314.13 Mil.
Personalis's Cash Flow from Operations for the trailing twelve months (TTM) ended in Jun. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-92.30 Mil.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Personalis (PSNL) has a EV-to-OCF of -14.24 as of Aug. 18, 2026. According to the industry distribution chart, Personalis ranks #34 out of 212 companies in the Medical Diagnostics & Research industry, placing it in the top 16%.
Is Personalis' EV-to-OCF too high?
Personalis' current EV-to-OCF is -14.24. Based on the distribution chart, Personalis ranks #34 out of 212 companies in the Medical Diagnostics & Research industry, which is in the top quartile — a strong position relative to peers. Overall, Personalis has a GF Score™ of 58/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Personalis' EV-to-OCF compare to FRNM and OPK?
According to the Medical Diagnostics & Research industry distribution chart, Personalis ranks #34 out of 212 companies for EV-to-OCF. This places Personalis in the top 16% of its industry — outperforming the majority of peers. The industry median EV-to-OCF is 6.24. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-OCF for a Medical Diagnostics & Research company?
The median EV-to-OCF among Medical Diagnostics & Research companies is 6.24, based on 212 companies in the industry. Companies in the top quartile (top 25%) have a EV-to-OCF significantly above this median, while those in the bottom quartile fall well below. However, EV-to-OCF should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-OCF mean?
A high EV-to-OCF can signal that a stock is expensive relative to its fundamentals. For the Medical Diagnostics & Research industry, the median EV-to-OCF is 6.24 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Personalis's current EV-to-OCF is -14.24. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Personalis stock overvalued right now?
Based on GuruFocus' analysis, Personalis (PSNL) is currently considered Significantly Overvalued. The stock's GF Value™ is $2.45, compared to a current price of $13.94 — trading 469% above its estimated fair value. The current EV-to-OCF is -14.24. Personalis' overall GF Score™ is 58/100 with 9 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-OCF calculated?
EV-to-OCF is calculated from a company's financial statements. For Personalis (PSNL), the current EV-to-OCF is -14.24 as of Aug. 18, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Personalis (PSNL) Overvalued in 2026?
Based on GuruFocus' analysis, Personalis stock appears to be overvalued.
The current stock price of $13.94 is trading 469% above its estimated GF Value™ of $2.45.
GuruFocus considers Personalis to be Significantly Overvalued.
Key valuation signals for PSNL:
EV-to-OCF: -14.24
GF Value™: $2.45 vs. price of $13.94 (469% above fair value)
No single metric tells the full story. See the PSNL stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Personalis Inc is a provider of genomic sequencing and analytics solutions to support the development of personalized cancer vaccines and other next-generation cancer immunotherapies. It has one segment, the sale of sequencing and data analysis services. The company' products include ImmunoID NeXT, NeXT Personal, NeXT Dx Test, and other pharma research solutions.
58GF Score
Get the complete analysis for PSNL
EV-to-OCF is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
Quick Browse
Personalize
Premium Gurus 
Create New Portfolio
PSNL has been successfully added to your 
