Ionis Pharmaceuticals (LTS:0JDI) FCF Yield %: -7.29 (As of Jun. 28, 2026)


LTS:0JDI Ionis Pharmaceuticals Inc LTS:0JDI
62 GF Score
Price $80.36
GF Value $53.57
Valuation Significantly Overvalued
! 8 Warning Signs
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What is Ionis Pharmaceuticals FCF Yield %?

Ionis Pharmaceuticals LTS:0JDI +2.08% 62 FCF Yield % is -7.29 as of Jun. 28, 2026. GuruFocus rates LTS:0JDI with a GF Score™ of 62/100 and a GF Value™ of $53.57 (Significantly Overvalued). The stock has 8 warning signs investors should review. Among 1,416 Biotechnology companies, Ionis Pharmaceuticals ranks better than 55.58% on this metric.

FCF Yield % is calculated as Free Cash Flow divided by Market Capitalization. It is a financial solvency ratio that compares the free cash flow a company is expected to earn against its market value.

As of today, Ionis Pharmaceuticals's Trailing 12-Month Free Cash Flow is $-978 Mil, and Market Cap is $13,416 Mil. Therefore, Ionis Pharmaceuticals's FCF Yield % for today is -7.29%.

The historical rank and industry rank for Ionis Pharmaceuticals's FCF Yield % or its related term are showing as below:

LTS:0JDI' s FCF Yield % Range Over the Past 10 Years
Min: -13.01   Med: -0.08   Max: 9.35
Current: -7.29


During the past 13 years, the highest FCF Yield % of Ionis Pharmaceuticals was 9.35%. The lowest was -13.01%. And the median was -0.08%.

LTS:0JDI's FCF Yield % is ranked better than
55.58% of 1416 companies
in the Biotechnology industry
Industry Median: -9.62 vs LTS:0JDI: -7.29

Ionis Pharmaceuticals's FCF Margin % for the quarter that ended in Mar. 2026 was -331.61%.


Ionis Pharmaceuticals FCF Yield % Explanation

Similar to Earnings Yield %, FCF Yield % is financial solvency ratio. A lower ratio suggests a less attractive investment, indicating that investors might not receive substantial returns in proportion to their investment. Conversely, a high free cash flow yield signals that a company generates sufficient cash to comfortably meet its debts, obligations, and dividend payments, making it a promising investment choice.


Ionis Pharmaceuticals FCF Yield % Related Terms


Ionis Pharmaceuticals FCF Yield % Historical Data

* Premium members only.

The historical data trend for Ionis Pharmaceuticals's FCF Yield % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Ionis Pharmaceuticals FCF Yield % Chart

Ionis Pharmaceuticals Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
FCF Yield %
Get a 7-Day Free Trial Premium Member Only Premium Member Only 0.29 -5.64 -4.65 -9.99 -2.51

Ionis Pharmaceuticals Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
FCF Yield % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -13.80 8.68 -5.32 -4.94 -26.22

LTS:0JDI vs EXEL, BBIO, AXSM: FCF Yield % Comparison

For the Biotechnology subindustry, Ionis Pharmaceuticals's FCF Yield %, along with its competitors' market caps and FCF Yield % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Ionis Pharmaceuticals FCF Yield % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Ionis Pharmaceuticals's FCF Yield % distribution charts can be found below:

* The bar in red indicates where Ionis Pharmaceuticals's FCF Yield % falls into.


LTS:0JDI
62GF Score
Ionis Pharmaceuticals Inc LTS:0JDI
FCF Yield % is just one metric. See GF Score™, valuation, warning signs, and more.
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Ionis Pharmaceuticals FCF Yield % Calculation

FCF Yield % is a financial solvency ratio that compares the free cash flow a company is expected to earn against its market value.

Ionis Pharmaceuticals's FCF Yield % for the fiscal year that ended in Dec. 2025 is calculated as

FCF Yield %=Free Cash Flow / Market Cap
=-325.667 / 12977.9626635
=-2.51%

Ionis Pharmaceuticals's annualized FCF Yield % for the quarter that ended in Mar. 2026 is calculated as

FCF Yield %=Free Cash Flow * Annualized Factor / Market Cap
=-816.068 * 4 / 12450.9451
=-26.22%

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about FCF Yield % →
What does a FCF Yield % of -7.29 mean?
Ionis Pharmaceuticals (LTS:0JDI) has a FCF Yield % of -7.29 as of Jun. 28, 2026. FCF Yield is calculated as Free Cash Flow divided by Market Capitalization. View historical data on Ionis Pharmaceuticals and its competitors. According to the industry distribution chart, Ionis Pharmaceuticals ranks #629 out of 1416 companies in the Biotechnology industry, placing it in the top 44.4%.
Is Ionis Pharmaceuticals' FCF Yield % too high?
Ionis Pharmaceuticals' current FCF Yield % is -7.29. Based on the distribution chart, Ionis Pharmaceuticals ranks #629 out of 1416 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Ionis Pharmaceuticals has a GF Score™ of 62/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Ionis Pharmaceuticals' FCF Yield % compare to EXEL and BBIO?
According to the Biotechnology industry distribution chart, Ionis Pharmaceuticals ranks #629 out of 1416 companies for FCF Yield %. This puts Ionis Pharmaceuticals in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good FCF Yield % for a Biotechnology company?
A good FCF Yield % depends on the Biotechnology industry context. However, FCF Yield % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high FCF Yield % mean?
A high FCF Yield % can signal that a stock is expensive relative to its fundamentals. FCF Yield is calculated as Free Cash Flow divided by Market Capitalization. View historical data on Ionis Pharmaceuticals and its competitors. Ionis Pharmaceuticals's current FCF Yield % is -7.29. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Ionis Pharmaceuticals stock overvalued right now?
Based on GuruFocus' analysis, Ionis Pharmaceuticals (LTS:0JDI) is currently considered Significantly Overvalued. The stock's GF Value™ is $53.57, compared to a current price of $80.36 — trading 50% above its estimated fair value. The current FCF Yield % is -7.29. Ionis Pharmaceuticals' overall GF Score™ is 62/100 with 8 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is FCF Yield % calculated?
FCF Yield % is calculated from a company's financial statements. For Ionis Pharmaceuticals (LTS:0JDI), the current FCF Yield % is -7.29 as of Jun. 28, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Ionis Pharmaceuticals (LTS:0JDI) Overvalued in 2026?

Based on GuruFocus' analysis, Ionis Pharmaceuticals stock appears to be overvalued. The current stock price of $80.36 is trading 50% above its estimated GF Value™ of $53.57. GuruFocus considers Ionis Pharmaceuticals to be Significantly Overvalued.

Key valuation signals for LTS:0JDI:

  • FCF Yield %: -7.29
  • GF Value™: $53.57 vs. price of $80.36 (50% above fair value)
  • GF Score™: 62/100 with 8 warning signs

No single metric tells the full story. See the LTS:0JDI stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Ionis Pharmaceuticals Business Description

Address 2855 Gazelle Court, Carlsbad, CA, USA, 92010
Ionis Pharmaceuticals is the leading developer of antisense technology to discover and develop novel drugs. Its broad clinical and preclinical pipeline targets a wide variety of diseases, with an emphasis on cardiovascular, metabolic, neurological, and rare diseases. Ionis and Biogen brought Spinraza to market in 2016 as a treatment for spinal muscular atrophy, and Biogen launched ALS drug Qalsody in 2023. Ionis brought two additional drugs to market via its cardiovascular-focused subsidiary Akcea, including ATTR amyloidosis drug Tegsedi (2018) and cardiology drug Waylivra (Europe, 2019). Ionis and AstraZeneca launched polyneuropathy drug Wainua in 2024. Ionis marked its first two independent launches in 2025 for Tryngolza (for FCS) and Dawnzera (for HAE).
62GF Score

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FCF Yield % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$80.36
Price
$53.57
GF Value