Ionis Pharmaceuticals (MEX:IONS) OCF Yield %: -6.95 (As of Jul. 01, 2026)


MEX:IONS Ionis Pharmaceuticals Inc MEX:IONS
65 GF Score
Price MXN1,150.00
GF Value MXN782.91
! 8 Warning Signs
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What is Ionis Pharmaceuticals OCF Yield %?

Ionis Pharmaceuticals MEX:IONS 65 OCF Yield % is -6.95 as of Jul. 01, 2026. GuruFocus rates MEX:IONS with a GF Score™ of 65/100 and a GF Value™ of MXN782.91. The stock has 8 warning signs investors should review. Among 1,415 Biotechnology companies, Ionis Pharmaceuticals ranks better than 53.22% on this metric.

OCF Yield % is calculated as Cash Flow from Operations divided by Market Capitalization. It is a financial solvency ratio that compares the operating cash flow a company is expected to earn against its market value.

As of today, Ionis Pharmaceuticals's Trailing 12-Month Cash Flow from Operations is MXN-16,338 Mil, and Market Cap is MXN229,564 Mil. Therefore, Ionis Pharmaceuticals's OCF Yield % for today is -6.95%.

The historical rank and industry rank for Ionis Pharmaceuticals's OCF Yield % or its related term are showing as below:

MEX:IONS' s OCF Yield % Range Over the Past 10 Years
Min: -11.67   Med: 0.42   Max: 10.02
Current: -6.95


During the past 13 years, the highest OCF Yield % of Ionis Pharmaceuticals was 10.02%. The lowest was -11.67%. And the median was 0.42%.

MEX:IONS's OCF Yield % is ranked better than
53.22% of 1415 companies
in the Biotechnology industry
Industry Median: -8.19 vs MEX:IONS: -6.95

Ionis Pharmaceuticals's OCF Margin % for the quarter that ended in Mar. 2026 was %.


Ionis Pharmaceuticals OCF Yield % Explanation

Similar to Earnings Yield %, OCF Yield % is financial solvency ratio. A lower ratio suggests a less attractive investment, indicating that investors might not receive substantial returns in proportion to their investment. Conversely, a high operating cash flow yield signals that a company generates sufficient cash to comfortably meet its debts, obligations, and dividend payments, making it a promising investment choice.


Ionis Pharmaceuticals OCF Yield % Related Terms


Ionis Pharmaceuticals OCF Yield % Historical Data

* Premium members only.

The historical data trend for Ionis Pharmaceuticals's OCF Yield % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Ionis Pharmaceuticals OCF Yield % Chart

Ionis Pharmaceuticals Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
OCF Yield %
Get a 7-Day Free Trial Premium Member Only Premium Member Only 0.72 -4.29 -4.90 -8.90 -2.58

Ionis Pharmaceuticals Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
OCF Yield % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -11.99 11.07 -5.20 -5.28 -29.97

MEX:IONS vs EXEL, BBIO, AXSM: OCF Yield % Comparison

For the Biotechnology subindustry, Ionis Pharmaceuticals's OCF Yield %, along with its competitors' market caps and OCF Yield % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Ionis Pharmaceuticals OCF Yield % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Ionis Pharmaceuticals's OCF Yield % distribution charts can be found below:

* The bar in red indicates where Ionis Pharmaceuticals's OCF Yield % falls into.


MEX:IONS
65GF Score
Ionis Pharmaceuticals Inc MEX:IONS
OCF Yield % is just one metric. See GF Score™, valuation, warning signs, and more.
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Ionis Pharmaceuticals OCF Yield % Calculation

OCF Yield % is a financial solvency ratio that compares the operating cash flow a company is expected to earn against its market value.

Ionis Pharmaceuticals's OCF Yield % for the fiscal year that ended in Dec. 2025 is calculated as

OCF Yield %=Cash Flow from Operations / Market Cap
=-4836.025 / 187800.75
=-2.58%

Ionis Pharmaceuticals's annualized OCF Yield % for the quarter that ended in Mar. 2026 is calculated as

OCF Yield %=Cash Flow from Operations * Annualized Factor / Market Cap
=-14296.667 * 4 / 190787.3
=-29.97%

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about OCF Yield % →
What does a OCF Yield % of -6.95 mean?
Ionis Pharmaceuticals (MEX:IONS) has a OCF Yield % of -6.95 as of Jul. 01, 2026. OCF Yield is calculated as Cash Flow from Operations divided by Market Capitalization. View historical data on Ionis Pharmaceuticals and its competitors. According to the industry distribution chart, Ionis Pharmaceuticals ranks #662 out of 1415 companies in the Biotechnology industry, placing it in the top 46.8%.
Is Ionis Pharmaceuticals' OCF Yield % too high?
Ionis Pharmaceuticals' current OCF Yield % is -6.95. Based on the distribution chart, Ionis Pharmaceuticals ranks #662 out of 1415 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Ionis Pharmaceuticals has a GF Score™ of 65/100, reflecting its overall financial health beyond just this single metric.
How does Ionis Pharmaceuticals' OCF Yield % compare to EXEL and BBIO?
According to the Biotechnology industry distribution chart, Ionis Pharmaceuticals ranks #662 out of 1415 companies for OCF Yield %. This puts Ionis Pharmaceuticals in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good OCF Yield % for a Biotechnology company?
A good OCF Yield % depends on the Biotechnology industry context. However, OCF Yield % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high OCF Yield % mean?
A high OCF Yield % can signal that a stock is expensive relative to its fundamentals. OCF Yield is calculated as Cash Flow from Operations divided by Market Capitalization. View historical data on Ionis Pharmaceuticals and its competitors. Ionis Pharmaceuticals's current OCF Yield % is -6.95. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Ionis Pharmaceuticals stock overvalued right now?
Ionis Pharmaceuticals (MEX:IONS) has a current OCF Yield % of -6.95. The stock's GF Value™ is MXN782.91, compared to a current price of MXN1,150.00 — trading 46.9% above its estimated fair value. The current OCF Yield % is -6.95. Ionis Pharmaceuticals' overall GF Score™ is 65/100 with 8 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is OCF Yield % calculated?
OCF Yield % is calculated from a company's financial statements. For Ionis Pharmaceuticals (MEX:IONS), the current OCF Yield % is -6.95 as of Jul. 01, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Ionis Pharmaceuticals (MEX:IONS) Overvalued in 2026?

Based on GuruFocus' analysis, Ionis Pharmaceuticals stock appears to be overvalued. The current stock price of MXN1,150.00 is trading 46.9% above its estimated GF Value™ of MXN782.91.

Key valuation signals for MEX:IONS:

  • OCF Yield %: -6.95
  • GF Value™: MXN782.91 vs. price of MXN1,150.00 (46.9% above fair value)
  • GF Score™: 65/100 with 8 warning signs

No single metric tells the full story. See the MEX:IONS stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Ionis Pharmaceuticals Business Description

Address 2855 Gazelle Court, Carlsbad, CA, USA, 92010
Ionis Pharmaceuticals is the leading developer of antisense technology to discover and develop novel drugs. Its broad clinical and preclinical pipeline targets a wide variety of diseases, with an emphasis on cardiovascular, metabolic, neurological, and rare diseases. Ionis and Biogen brought Spinraza to market in 2016 as a treatment for spinal muscular atrophy, and Biogen launched ALS drug Qalsody in 2023. Ionis brought two additional drugs to market via its cardiovascular-focused subsidiary Akcea, including ATTR amyloidosis drug Tegsedi (2018) and cardiology drug Waylivra (Europe, 2019). Ionis and AstraZeneca launched polyneuropathy drug Wainua in 2024. Ionis marked its first two independent launches in 2025 for Tryngolza (for FCS) and Dawnzera (for HAE).
65GF Score

Get the complete analysis for MEX:IONS

OCF Yield % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

MXN1,150.00
Price
MXN782.91
GF Value