Lepu Biopharma Co (HKSE:02157) Operating Margin %: 2.13% (As of Dec. 2025)

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HKSE:02157 Lepu Biopharma Co Ltd HKSE:02157
44 GF Score
Price HK$4.65
GF Value HK$15.69
Valuation Possible Value Trap
! 6 Warning Signs
View Full Analysis

What is Lepu Biopharma Co Operating Margin %?

Lepu Biopharma Co HKSE:02157 -2.92% 44 Operating Margin % is 2.13% as of Dec. 2025. GuruFocus rates HKSE:02157 with a GF Score™ of 44/100 and a GF Value™ of HK$15.69 (Possible Value Trap). The stock has 6 warning signs investors should review. Among 942 Biotechnology companies, Lepu Biopharma Co ranks better than 81.21% on this metric.

Operating Margin % is calculated as Operating Income divided by its Revenue. Lepu Biopharma Co's Operating Income for the six months ended in Dec. 2025 was HK$11 Mil. Lepu Biopharma Co's Revenue for the six months ended in Dec. 2025 was HK$518 Mil. Therefore, Lepu Biopharma Co's Operating Margin % for the quarter that ended in Dec. 2025 was 2.13%.

The historical rank and industry rank for Lepu Biopharma Co's Operating Margin % or its related term are showing as below:

HKSE:02157' s Operating Margin % Range Over the Past 10 Years
Min: -4124.03   Med: -136.24   Max: 10.15
Current: 10.11


HKSE:02157's Operating Margin % is ranked better than
81.21% of 942 companies
in the Biotechnology industry
Industry Median: -85.73 vs HKSE:02157: 10.11

Lepu Biopharma Co's 5-Year Average Operating Margin % Growth Rate was 0.00% per year.

Lepu Biopharma Co's Operating Income for the six months ended in Dec. 2025 was HK$11 Mil. Its Operating Income for the trailing twelve months (TTM) ended in Dec. 2025 was HK$104 Mil.

Warning Sign:

Lepu Biopharma Co Ltd had lost money in 67% of the time over the past 3quarters.


Lepu Biopharma Co  (HKSE:02157) Operating Margin % Explanation

Just like Gross Margin %, it is important to see a company maintains its operating margin over time. Among the same industry, a company with higher operating margin is more efficient in its operation. It is also more stable during industry slowdown or recessions. Peter Lynch prefers those with higher margins than those with lower margins.


Be Aware

Operating Margin % can be manipulated by adjusting the rate of depreciation, depletion and amortization (DDA).

If a company is facing competition, its Operating Margin % may decline. Often the Operating Margin % declines well before the company's Revenue or even profit decline. Therefore, Operating Margin % is a very important indicator of whether the company is facing problems.

For instance, by 2012, Nokia (NOK)'s problems were well known and its stock had lost more than 90% of its market value since 2007. But Nokia’s Operating Margin % had already been in decline since 2002, although its Earnings per Share (Diluted) were still rising. Investors who paid attention to Operating Margin % would have avoided this huge loss. The same can be said for Research-in-Motion (RIMM).

Therefore, Operating Margin % is a very important screening filter for GuruFocus. GuruFocus's Buffett-Munger screener requires that the profit margin is either consistent or expanding. The Model Portfolio of the Buffett-Munger screener has outperformed the market every year since inception in 2009.


Lepu Biopharma Co Operating Margin % Related Terms


Lepu Biopharma Co Operating Margin % Historical Data

* Premium members only.

The historical data trend for Lepu Biopharma Co's Operating Margin % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Lepu Biopharma Co Operating Margin % Chart

Lepu Biopharma Co Annual Data
Trend Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Operating Margin %
Get a 7-Day Free Trial 0.00 -4,124.03 -170.55 -101.93 10.15

Lepu Biopharma Co Semi-Annual Data
Dec19 Dec20 Jun21 Dec21 Jun22 Dec22 Jun23 Dec23 Jun24 Dec24 Jun25 Dec25
Operating Margin % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only -347.09 -133.69 -83.88 18.23 2.13

HKSE:02157 vs VRTX, REGN, RVMD: Operating Margin % Comparison

For the Biotechnology subindustry, Lepu Biopharma Co's Operating Margin %, along with its competitors' market caps and Operating Margin % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Lepu Biopharma Co Operating Margin % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Lepu Biopharma Co's Operating Margin % distribution charts can be found below:

* The bar in red indicates where Lepu Biopharma Co's Operating Margin % falls into.


HKSE:02157
44GF Score
Lepu Biopharma Co Ltd HKSE:02157
Operating Margin % is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Lepu Biopharma Co Operating Margin % Calculation

Operating Margin % - also known as operating income margin, operating profit margin and return on sales (ROS) - is the ratio of Operating Income divided by net sales or Revenue, usually presented in percent.

Lepu Biopharma Co's Operating Margin % for the fiscal year that ended in Dec. 2025 is calculated as

Operating Margin %=Operating Income (A: Dec. 2025 ) / Revenue (A: Dec. 2025 )
=104.876 / 1032.773
=10.15 %

Lepu Biopharma Co's Operating Margin % for the quarter that ended in Dec. 2025 is calculated as

Operating Margin %=Operating Income (Q: Dec. 2025 ) / Revenue (Q: Dec. 2025 )
=11.047 / 518.035
=2.13 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about Operating Margin % →
What does a Operating Margin % of 2.13% mean?
Lepu Biopharma Co (HKSE:02157) has a Operating Margin % of 2.13% as of Dec. 2025. Operating margin is the ratio of total operating income to net sales. View historical data on Lepu Biopharma Co and its competitors. According to the industry distribution chart, Lepu Biopharma Co ranks #177 out of 942 companies in the Biotechnology industry, placing it in the top 18.8%.
Is Lepu Biopharma Co's Operating Margin % too high?
Lepu Biopharma Co's current Operating Margin % is 2.13%. Based on the distribution chart, Lepu Biopharma Co ranks #177 out of 942 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers. Overall, Lepu Biopharma Co has a GF Score™ of 44/100 and is considered Possible Value Trap, reflecting its overall financial health beyond just this single metric.
How does Lepu Biopharma Co's Operating Margin % compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Lepu Biopharma Co ranks #177 out of 942 companies for Operating Margin %. This places Lepu Biopharma Co in the top 19% of its industry — outperforming the majority of peers. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Operating Margin % for a Biotechnology company?
A good Operating Margin % depends on the Biotechnology industry context. However, Operating Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Operating Margin % mean?
A high Operating Margin % can signal that a stock is expensive relative to its fundamentals. Operating margin is the ratio of total operating income to net sales. View historical data on Lepu Biopharma Co and its competitors. Lepu Biopharma Co's current Operating Margin % is 2.13%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Lepu Biopharma Co stock overvalued right now?
Based on GuruFocus' analysis, Lepu Biopharma Co (HKSE:02157) is currently considered Possible Value Trap. The stock's GF Value™ is HK$15.69, compared to a current price of HK$4.65 — trading 70.4% below its estimated fair value. The current Operating Margin % is 2.13%. Lepu Biopharma Co's overall GF Score™ is 44/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Operating Margin % calculated?
Operating Margin % is calculated from a company's financial statements. For Lepu Biopharma Co (HKSE:02157), the current Operating Margin % is 2.13% as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Lepu Biopharma Co (HKSE:02157) Overvalued in 2026?

Based on GuruFocus' analysis, Lepu Biopharma Co stock appears to be undervalued. The current stock price of HK$4.65 is trading 70.4% below its estimated GF Value™ of HK$15.69. GuruFocus considers Lepu Biopharma Co to be Possible Value Trap.

Key valuation signals for HKSE:02157:

  • Operating Margin %: 2.13%
  • GF Value™: HK$15.69 vs. price of HK$4.65 (70.4% below fair value)
  • GF Score™: 44/100 with 6 warning signs

No single metric tells the full story. See the HKSE:02157 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Lepu Biopharma Co Business Description

Address Lianheng Road, Block 4, No. 651, Minhang District, Shanghai, CHN, 201112
Lepu Biopharma Co Ltd is focused on discovering, developing, and commercializing drug candidates in anti-tumor targeted therapy and oncology immunotherapy. Its commercial products include Puyouheng (Pucotenlimab Injection) and Meiyouheng (Becotatug Vedotin Injection). In addition, two other products, CMG901 and MRG007, have also been licensed out through its business development activities. Additionally, the company has several clinical-stage drug candidates and clinical-stage combination therapies of candidates, which are being developed as targeted therapeutics and immunotherapeutics. The various drug candidates in its pipeline include MRG003, MRG002, MRG004A, CG0070, MRG001, and MRG006A, among others. Geographically, the company generates maximum revenue from the Chinese mainland.
44GF Score

Get the complete analysis for HKSE:02157

Operating Margin % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

HK$4.65
Price
HK$15.69
GF Value