Ono Pharmaceutical CoMEX:4528N 88 Operating Margin % is 3.32% as of Mar. 2026, which is 88% below its 10-year median of 27.53. GuruFocus rates MEX:4528N with a GF Score™ of 88/100 and a GF Value™ of MXN324.16. The stock has 2 warning signs investors should review. Among 952 Drug Manufacturers companies, Ono Pharmaceutical Co ranks better than 77.73% on this metric.
Ono Pharmaceutical Co Ltd operating margin has been in a 5-year decline. The average rate of decline per year is -14.3%.
The historical rank and industry rank for Ono Pharmaceutical Co's Operating Margin % or its related term are showing as below:
MEX:4528N'
s Operating Margin % Range Over the Past 10 Years
Min: 12.27 Med: 27.53 Max: 31.82
Current: 17.88
MEX:4528N's Operating Margin % is ranked better than 77.73% of 952
companies
in the Drug Manufacturers industry
Industry Median: 7.58
vs MEX:4528N: 17.88
Ono Pharmaceutical Co's 5-Year Average Operating Margin % Growth Rate was -14.30% per year.
Ono Pharmaceutical Co (MEX:4528N) Operating Margin % Explanation
Just like Gross Margin %, it is important to see a company maintains its operating margin over time. Among the same industry, a company with higher operating margin is more efficient in its operation. It is also more stable during industry slowdown or recessions. Peter Lynch prefers those with higher margins than those with lower margins.
Be Aware
Operating Margin % can be manipulated by adjusting the rate of depreciation, depletion and amortization (DDA).
If a company is facing competition, its Operating Margin % may decline. Often the Operating Margin % declines well before the company's Revenue or even profit decline. Therefore, Operating Margin % is a very important indicator of whether the company is facing problems.
For instance, by 2012, Nokia (NOK)'s problems were well known and its stock had lost more than 90% of its market value since 2007. But Nokias Operating Margin % had already been in decline since 2002, although its Earnings per Share (Diluted) were still rising. Investors who paid attention to Operating Margin % would have avoided this huge loss. The same can be said for Research-in-Motion (RIMM).
Therefore, Operating Margin % is a very important screening filter for GuruFocus. GuruFocus's Buffett-Munger screener requires that the profit margin is either consistent or expanding. The Model Portfolio of the Buffett-Munger screener has outperformed the market every year since inception in 2009.
Ono Pharmaceutical Co Operating Margin % Related Terms
Ono Pharmaceutical Co Operating Margin % Historical Data
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The historical data trend for Ono Pharmaceutical Co's Operating Margin % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
MEX:4528N vs LLY, JNJ, ABBV: Operating Margin % Comparison
For the Drug Manufacturers - General subindustry, Ono Pharmaceutical Co's Operating Margin %, along with its competitors' market caps and Operating Margin % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Ono Pharmaceutical Co Operating Margin % vs Drug Manufacturers Industry
For the Drug Manufacturers industry and Healthcare sector, Ono Pharmaceutical Co's Operating Margin % distribution charts can be found below:
* The bar in red indicates where Ono Pharmaceutical Co's Operating Margin % falls into.
Ono Pharmaceutical Co Operating Margin % Calculation
Operating Margin % - also known as operating income margin, operating profit margin and return on sales (ROS) - is the ratio of Operating Income divided by net sales or Revenue, usually presented in percent.
Ono Pharmaceutical Co's Operating Margin % for the fiscal year that ended in Mar. 2026 is calculated as
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Ono Pharmaceutical Co (MEX:4528N) has a Operating Margin % of 3.32% as of Mar. 2026. Operating margin is the ratio of total operating income to net sales. View historical data on Ono Pharmaceutical Co and its competitors. This is 88% below median its historical median of 27.53. Over the past decade, Ono Pharmaceutical Co's Operating Margin % has ranged from 12.27 to 31.82. According to the industry distribution chart, Ono Pharmaceutical Co ranks #212 out of 952 companies in the Drug Manufacturers industry, placing it in the top 22.3%.
Is Ono Pharmaceutical Co's Operating Margin % too high?
Ono Pharmaceutical Co's current Operating Margin % of 3.32% is 88% below median its 10-year median of 27.53. Over the past 10 years, this metric has ranged from a low of 12.27 to a high of 31.82. The Drug Manufacturers industry median Operating Margin % is 7.58. Ono Pharmaceutical Co's value of 3.32% is 56.2% below this industry median. Based on the distribution chart, Ono Pharmaceutical Co ranks #212 out of 952 companies in the Drug Manufacturers industry, which is in the top quartile — a strong position relative to peers. Overall, Ono Pharmaceutical Co has a GF Score™ of 88/100, reflecting its overall financial health beyond just this single metric.
How does Ono Pharmaceutical Co's Operating Margin % compare to LLY and JNJ?
According to the Drug Manufacturers industry distribution chart, Ono Pharmaceutical Co ranks #212 out of 952 companies for Operating Margin %. This places Ono Pharmaceutical Co in the top 22% of its industry — outperforming the majority of peers. The industry median Operating Margin % is 7.58. Ono Pharmaceutical Co's value of 3.32% is 56.2% below this benchmark. Historically, Ono Pharmaceutical Co's own Operating Margin % has ranged from 12.27 to 31.82 over the past decade. While the company's 10-year median is 27.53 vs. the industry median of 7.58, Ono Pharmaceutical Co has consistently been below the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Operating Margin % for a Drug Manufacturers company?
The median Operating Margin % among Drug Manufacturers companies is 7.58, based on 952 companies in the industry. Companies in the top quartile (top 25%) have a Operating Margin % significantly above this median, while those in the bottom quartile fall well below. However, Operating Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Ono Pharmaceutical Co's current Operating Margin % of 3.32% is 56.2% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Operating Margin % mean?
A high Operating Margin % can signal that a stock is expensive relative to its fundamentals. Operating margin is the ratio of total operating income to net sales. View historical data on Ono Pharmaceutical Co and its competitors. For the Drug Manufacturers industry, the median Operating Margin % is 7.58 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Ono Pharmaceutical Co's current Operating Margin % is 3.32%, which is 88% below median its own 10-year median of 27.53. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Ono Pharmaceutical Co stock overvalued right now?
Ono Pharmaceutical Co (MEX:4528N) has a current Operating Margin % of 3.32%. The stock's GF Value™ is MXN324.16, compared to a current price of MXN341.69 — trading 5.4% above its estimated fair value. The current Operating Margin % is 3.32%, which is 88% below median its 10-year median of 27.53 and 56.2% below the Drug Manufacturers industry median of 7.58. Ono Pharmaceutical Co's overall GF Score™ is 88/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Operating Margin % calculated?
Operating Margin % is calculated from a company's financial statements. For Ono Pharmaceutical Co (MEX:4528N), the current Operating Margin % is 3.32% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Ono Pharmaceutical Co (MEX:4528N) Overvalued in 2026?
Based on GuruFocus' analysis, Ono Pharmaceutical Co stock appears to be overvalued.
The current stock price of MXN341.69 is trading 5.4% above its estimated GF Value™ of MXN324.16.
Key valuation signals for MEX:4528N:
Operating Margin %: 3.32% (88% below median its 10-year median of 27.53)
GF Value™: MXN324.16 vs. price of MXN341.69 (5.4% above fair value)
Industry Position: 56.2% below the Drug Manufacturers median (#212 of 952)
No single metric tells the full story. See the MEX:4528N stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Ono Pharmaceutical Co Ltd is a drug manufacturer with a focus on drug discovery in areas of unmet medical needs. The vast majority of the company's revenue is derived from its circulatory and respiratory drugs, followed by its metabolic drugs and vitamins. The company also reports revenue derived from royalties. The bulk of the company's sales is generated in Japan, followed by the rest of Asia and Europe.
88GF Score
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