SERA (Sera Prognostics) Operating Margin %: -66,857.14% (As of Mar. 2026)


SERA Sera Prognostics Inc SERA
70 GF Score
Price $1.84
GF Value $1.86
Valuation Fairly Valued
! 5 Warning Signs
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What is Sera Prognostics Operating Margin %?

Sera Prognostics SERA -2.17% 70 Operating Margin % is -66,857.14% as of Mar. 2026. GuruFocus rates SERA with a GF Score™ of 70/100 and a GF Value™ of $1.86 (Fairly Valued). The stock has 5 warning signs investors should review. Among 816 Medical Devices & Instruments companies, Sera Prognostics ranks worse than 99.63% on this metric.

Operating Margin % is calculated as Operating Income divided by its Revenue. Sera Prognostics's Operating Income for the three months ended in Mar. 2026 was $-9.36 Mil. Sera Prognostics's Revenue for the three months ended in Mar. 2026 was $0.01 Mil. Therefore, Sera Prognostics's Operating Margin % for the quarter that ended in Mar. 2026 was -66,857.14%.

Good Sign:

Sera Prognostics Inc operating margin is expanding. Margin expansion is usually a good sign.

The historical rank and industry rank for Sera Prognostics's Operating Margin % or its related term are showing as below:

SERA' s Operating Margin % Range Over the Past 10 Years
Min: -71884   Med: -45066.67   Max: -13013.4
Current: -64235.09


SERA's Operating Margin % is ranked worse than
99.63% of 816 companies
in the Medical Devices & Instruments industry
Industry Median: 3.465 vs SERA: -64235.09

Sera Prognostics's 5-Year Average Operating Margin % Growth Rate was 6.40% per year.

Sera Prognostics's Operating Income for the three months ended in Mar. 2026 was $-9.36 Mil. Its Operating Income for the trailing twelve months (TTM) ended in Mar. 2026 was $-36.61 Mil.


Sera Prognostics  (NAS:SERA) Operating Margin % Explanation

Just like Gross Margin %, it is important to see a company maintains its operating margin over time. Among the same industry, a company with higher operating margin is more efficient in its operation. It is also more stable during industry slowdown or recessions. Peter Lynch prefers those with higher margins than those with lower margins.


Be Aware

Operating Margin % can be manipulated by adjusting the rate of depreciation, depletion and amortization (DDA).

If a company is facing competition, its Operating Margin % may decline. Often the Operating Margin % declines well before the company's Revenue or even profit decline. Therefore, Operating Margin % is a very important indicator of whether the company is facing problems.

For instance, by 2012, Nokia (NOK)'s problems were well known and its stock had lost more than 90% of its market value since 2007. But Nokia’s Operating Margin % had already been in decline since 2002, although its Earnings per Share (Diluted) were still rising. Investors who paid attention to Operating Margin % would have avoided this huge loss. The same can be said for Research-in-Motion (RIMM).

Therefore, Operating Margin % is a very important screening filter for GuruFocus. GuruFocus's Buffett-Munger screener requires that the profit margin is either consistent or expanding. The Model Portfolio of the Buffett-Munger screener has outperformed the market every year since inception in 2009.


Sera Prognostics Operating Margin % Related Terms


Sera Prognostics Operating Margin % Historical Data

* Premium members only.

The historical data trend for Sera Prognostics's Operating Margin % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Sera Prognostics Operating Margin % Chart

Sera Prognostics Annual Data
Trend Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Operating Margin %
Get a 7-Day Free Trial -43,164.63 -17,034.33 -13,013.40 -47,577.92 -45,066.67

Sera Prognostics Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Operating Margin % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -24,342.11 -54,823.53 -56,125.00 -89,540.00 -66,857.14

SERA vs ECOR, OM, RTGN: Operating Margin % Comparison

For the Medical Devices subindustry, Sera Prognostics's Operating Margin %, along with its competitors' market caps and Operating Margin % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Sera Prognostics Operating Margin % vs Medical Devices & Instruments Industry

For the Medical Devices & Instruments industry and Healthcare sector, Sera Prognostics's Operating Margin % distribution charts can be found below:

* The bar in red indicates where Sera Prognostics's Operating Margin % falls into.


SERA
70GF Score
Sera Prognostics Inc SERA
Operating Margin % is just one metric. See GF Score™, valuation, warning signs, and more.
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Sera Prognostics Operating Margin % Calculation

Operating Margin % - also known as operating income margin, operating profit margin and return on sales (ROS) - is the ratio of Operating Income divided by net sales or Revenue, usually presented in percent.

Sera Prognostics's Operating Margin % for the fiscal year that ended in Dec. 2025 is calculated as

Operating Margin %=Operating Income (A: Dec. 2025 ) / Revenue (A: Dec. 2025 )
=-36.504 / 0.081
=-45,066.67 %

Sera Prognostics's Operating Margin % for the quarter that ended in Mar. 2026 is calculated as

Operating Margin %=Operating Income (Q: Mar. 2026 ) / Revenue (Q: Mar. 2026 )
=-9.36 / 0.014
=-66,857.14 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about Operating Margin % →
What does a Operating Margin % of -66,857.14% mean?
Sera Prognostics (SERA) has a Operating Margin % of -66,857.14% as of Mar. 2026. Operating margin is the ratio of total operating income to net sales. View historical data on Sera Prognostics and its competitors. According to the industry distribution chart, Sera Prognostics ranks #813 out of 816 companies in the Medical Devices & Instruments industry, placing it in the top 99.6%.
Is Sera Prognostics' Operating Margin % too high?
Sera Prognostics' current Operating Margin % is -66,857.14%. Based on the distribution chart, Sera Prognostics ranks #813 out of 816 companies in the Medical Devices & Instruments industry, which is in the bottom quartile relative to peers. Overall, Sera Prognostics has a GF Score™ of 70/100 and is considered Fairly Valued, reflecting its overall financial health beyond just this single metric.
How does Sera Prognostics' Operating Margin % compare to ECOR and OM?
According to the Medical Devices & Instruments industry distribution chart, Sera Prognostics ranks #813 out of 816 companies for Operating Margin %. This places Sera Prognostics in the lower half of its industry. The industry median Operating Margin % is 3.47. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Operating Margin % for a Medical Devices & Instruments company?
The median Operating Margin % among Medical Devices & Instruments companies is 3.47, based on 816 companies in the industry. Companies in the top quartile (top 25%) have a Operating Margin % significantly above this median, while those in the bottom quartile fall well below. However, Operating Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Operating Margin % mean?
A high Operating Margin % can signal that a stock is expensive relative to its fundamentals. Operating margin is the ratio of total operating income to net sales. View historical data on Sera Prognostics and its competitors. For the Medical Devices & Instruments industry, the median Operating Margin % is 3.47 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Sera Prognostics's current Operating Margin % is -66,857.14%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Sera Prognostics stock overvalued right now?
Based on GuruFocus' analysis, Sera Prognostics (SERA) is currently considered Fairly Valued. The stock's GF Value™ is $1.86, compared to a current price of $1.84 — trading 1.1% below its estimated fair value. The current Operating Margin % is -66,857.14%. Sera Prognostics' overall GF Score™ is 70/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Operating Margin % calculated?
Operating Margin % is calculated from a company's financial statements. For Sera Prognostics (SERA), the current Operating Margin % is -66,857.14% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Sera Prognostics (SERA) Overvalued in 2026?

Based on GuruFocus' analysis, Sera Prognostics stock appears to be undervalued. The current stock price of $1.84 is trading 1.1% below its estimated GF Value™ of $1.86. GuruFocus considers Sera Prognostics to be Fairly Valued.

Key valuation signals for SERA:

  • Operating Margin %: -66,857.14%
  • GF Value™: $1.86 vs. price of $1.84 (1.1% below fair value)
  • GF Score™: 70/100 with 5 warning signs

No single metric tells the full story. See the SERA stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Sera Prognostics Business Description

Address 2749 East Parleys Way, Suite 200, Salt Lake City, UT, USA, 84109
Sera Prognostics Inc is a health diagnostic company. It is a women's health company utilizing the proprietary proteomics and bioinformatics platform, and data resources to improve maternal and neonatal health by discovering, developing, and commercializing blood-based biomarker tests, and predictive analytic products and services. The Company operates as one operating segment, which is developing and commercializing its medical diagnostic products and services.
70GF Score

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Operating Margin % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$1.84
Price
$1.86
GF Value