Just like Gross Margin %, it is important to see a company maintains its operating margin over time. Among the same industry, a company with higher operating margin is more efficient in its operation. It is also more stable during industry slowdown or recessions. Peter Lynch prefers those with higher margins than those with lower margins.
Be Aware
Operating Margin % can be manipulated by adjusting the rate of depreciation, depletion and amortization (DDA).
If a company is facing competition, its Operating Margin % may decline. Often the Operating Margin % declines well before the company's Revenue or even profit decline. Therefore, Operating Margin % is a very important indicator of whether the company is facing problems.
For instance, by 2012, Nokia (NOK)'s problems were well known and its stock had lost more than 90% of its market value since 2007. But Nokias Operating Margin % had already been in decline since 2002, although its Earnings per Share (Diluted) were still rising. Investors who paid attention to Operating Margin % would have avoided this huge loss. The same can be said for Research-in-Motion (RIMM).
Therefore, Operating Margin % is a very important screening filter for GuruFocus. GuruFocus's Buffett-Munger screener requires that the profit margin is either consistent or expanding. The Model Portfolio of the Buffett-Munger screener has outperformed the market every year since inception in 2009.
VYNE Therapeutics Operating Margin % Related Terms
VYNE Therapeutics Operating Margin % Historical Data
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The historical data trend for VYNE Therapeutics's Operating Margin % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
VYNE vs TPST, NXTC, QNCX: Operating Margin % Comparison
For the Biotechnology subindustry, VYNE Therapeutics's Operating Margin %, along with its competitors' market caps and Operating Margin % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
VYNE Therapeutics Operating Margin % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, VYNE Therapeutics's Operating Margin % distribution charts can be found below:
* The bar in red indicates where VYNE Therapeutics's Operating Margin % falls into.
Operating Margin % - also known as operating income margin, operating profit margin and return on sales (ROS) - is the ratio of Operating Income divided by net sales or Revenue, usually presented in percent.
VYNE Therapeutics's Operating Margin % for the fiscal year that ended in Dec. 2025 is calculated as
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
What does a Operating Margin % of -4,437.21% mean?
VYNE Therapeutics (VYNE) has a Operating Margin % of -4,437.21% as of Mar. 2026. Operating margin is the ratio of total operating income to net sales. View historical data on VYNE Therapeutics and its competitors. According to the industry distribution chart, VYNE Therapeutics ranks #852 out of 944 companies in the Biotechnology industry, placing it in the top 90.3%.
Is VYNE Therapeutics' Operating Margin % too high?
VYNE Therapeutics' current Operating Margin % is -4,437.21%. Based on the distribution chart, VYNE Therapeutics ranks #852 out of 944 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, VYNE Therapeutics has a GF Score™ of 37/100 and is considered Modestly Overvalued, reflecting its overall financial health beyond just this single metric.
How does VYNE Therapeutics' Operating Margin % compare to TPST and NXTC?
According to the Biotechnology industry distribution chart, VYNE Therapeutics ranks #852 out of 944 companies for Operating Margin %. This places VYNE Therapeutics in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Operating Margin % for a Biotechnology company?
A good Operating Margin % depends on the Biotechnology industry context. However, Operating Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Operating Margin % mean?
A high Operating Margin % can signal that a stock is expensive relative to its fundamentals. Operating margin is the ratio of total operating income to net sales. View historical data on VYNE Therapeutics and its competitors. VYNE Therapeutics's current Operating Margin % is -4,437.21%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is VYNE Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, VYNE Therapeutics (VYNE) is currently considered Modestly Overvalued. The stock's GF Value™ is $0.55, compared to a current price of $0.64 — trading 15.9% above its estimated fair value. The current Operating Margin % is -4,437.21%. VYNE Therapeutics' overall GF Score™ is 37/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Operating Margin % calculated?
Operating Margin % is calculated from a company's financial statements. For VYNE Therapeutics (VYNE), the current Operating Margin % is -4,437.21% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is VYNE Therapeutics (VYNE) Overvalued in 2026?
Based on GuruFocus' analysis, VYNE Therapeutics stock appears to be overvalued.
The current stock price of $0.64 is trading 15.9% above its estimated GF Value™ of $0.55.
GuruFocus considers VYNE Therapeutics to be Modestly Overvalued.
Key valuation signals for VYNE:
Operating Margin %: -4,437.21%
GF Value™: $0.55 vs. price of $0.64 (15.9% above fair value)
No single metric tells the full story. See the VYNE stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
VYNE Therapeutics Inc is a biopharmaceutical company focused on developing proprietary and differentiated therapies for the treatment of immuno-inflammatory conditions. The company is also in the pre-clinical stages of research, develop and commercialize products containing small molecule bromodomain and extra-terminal domain (BET) inhibitors for the treatment of any disease, disorder or condition in human. Its products include AMZEEQ, ZILXI, and FCD105.
37GF Score
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Operating Margin % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
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